Raghu R. Seethala
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View article: Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension
Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension Open
Importance Evidence supporting the safety of infusing vasopressors through peripheral intravenous catheters (peripheral vasopressors) is largely derived from single-center studies, limiting generalizability. Objective To evaluate factors a…
View article: Intubating intensivists decrease emergency physician and anesthesiologist interruptions: a single-site retrospective cohort study
Intubating intensivists decrease emergency physician and anesthesiologist interruptions: a single-site retrospective cohort study Open
View article: Multiorganizational and multidisciplinary high-fidelity simulation of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest
Multiorganizational and multidisciplinary high-fidelity simulation of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest Open
View article: Use and Outcomes of Sugammadex for Neurological Examination after Neuromuscular Blockade in the Emergency Department
Use and Outcomes of Sugammadex for Neurological Examination after Neuromuscular Blockade in the Emergency Department Open
Introduction: Non-depolarizing agents such as rocuronium and vecuronium are frequently used in the emergency department (ED) to facilitate intubation but may lead to delay in neurologic examination and intervention. Sugammadex is used for …
View article: Causes of Death Among Patients Supported by Extracorporeal Membrane Oxygenation
Causes of Death Among Patients Supported by Extracorporeal Membrane Oxygenation Open
Background: Mortality for patients who are critically ill receiving extracorporeal membrane oxygenation (ECMO) support (venovenous or venoarterial) is high, but the proximal causes of death have not been characterized fully. Research Quest…
View article: Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation Open
Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post–cardiac arrest (CA…
View article: A case of extracorporeal carbon dioxide removal for postpneumonectomy acute respiratory distress syndrome
A case of extracorporeal carbon dioxide removal for postpneumonectomy acute respiratory distress syndrome Open
View article: Effect of upper body venoarterial ECMO on systemic hemodynamics and oxygenation: A computational study
Effect of upper body venoarterial ECMO on systemic hemodynamics and oxygenation: A computational study Open
View article: Differences in Prevalence of Transfusion Protocols between Critically Ill Neurologic and Non-Neurologic Patient Populations
Differences in Prevalence of Transfusion Protocols between Critically Ill Neurologic and Non-Neurologic Patient Populations Open
This study describes the prevalence of blood transfusion protocols in ICUs caring for neurologically vs. non-neurologically injured patients across a sample of US ICUs. This prospective, observational multi-center cohort study is a subgrou…
View article: Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome
Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome Open
View article: Impact of adherence to procalcitonin antibiotic prescribing guideline recommendations for low procalcitonin levels on antibiotic use
Impact of adherence to procalcitonin antibiotic prescribing guideline recommendations for low procalcitonin levels on antibiotic use Open
Background The Procalcitonin Antibiotic Consensus Trial (ProACT) found provision of a procalcitonin antibiotic prescribing guideline to hospital-based clinicians did not reduce antibiotic use. Possible reasons include clinician reluctance …
View article: Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrest
Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrest Open
Summary Neurological injury is a major driver of mortality among patients hospitalized after cardiac arrest (CA). The early systemic inflammatory response after CA is associated with neurological injury and mortality but remains poorly def…
View article: The "July Effect" in the intensive care units revisited: A bi-institutional 6-year experience of 57,160 patients
The "July Effect" in the intensive care units revisited: A bi-institutional 6-year experience of 57,160 patients Open
View article: A large multicenter evaluation of quick Sequential Organ Failure Assessment (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) performance among hospitalized US Emergency Department patients with suspected infection
A large multicenter evaluation of quick Sequential Organ Failure Assessment (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) performance among hospitalized US Emergency Department patients with suspected infection Open
A large multicenter evaluation of quick Sequential Organ Failure Assessment (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) performance among hospitalized US Emergency Department patients with suspected infection
View article: Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States
Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States Open
View article: Critical Care Transport of Patients With COVID-19
Critical Care Transport of Patients With COVID-19 Open
Purpose: Critical care transport is associated with a high rate of adverse events, and the risks and outcomes of transporting critically ill patients during the COVID-19 pandemic have not been previously described. Materials and Methods: W…
View article: In-hospital cardiac arrest in patients with coronavirus 2019
In-hospital cardiac arrest in patients with coronavirus 2019 Open
View article: The impact of COVID‐19 on statewide EMS use for cardiac emergencies and stroke in Massachusetts
The impact of COVID‐19 on statewide EMS use for cardiac emergencies and stroke in Massachusetts Open
EMS use for certain time-sensitive conditions decreased after a statewide emergency declaration, irrespective of actual COVID-19 incidence, suggesting the decrease was related to perception instead of actual case counts. These findings hav…
View article: Feasibility and Safety of Prone Position Transport for Severe Hypoxemic Respiratory Failure Due to Coronavirus Disease 2019
Feasibility and Safety of Prone Position Transport for Severe Hypoxemic Respiratory Failure Due to Coronavirus Disease 2019 Open
Objectives: To assess the safety and feasibility of a new protocol for interhospital critical care transport of mechanically ventilated patients in the prone position during the coronavirus disease 2019 pandemic by nurse and paramedic crit…
View article: Ambulance Calls for Substance-Related Issues Before and After COVID-19
Ambulance Calls for Substance-Related Issues Before and After COVID-19 Open
Background: The United States is currently facing 2 epidemics: sustained morbidity and mortality from substance use and the more recent COVID-19 pandemic. We tested the hypothesis that the pandemic has disproportionately affected in…
View article: Transport of a Nonintubated Prone Patient with Severe Hypoxemic Respiratory Failure Due to COVID-19
Transport of a Nonintubated Prone Patient with Severe Hypoxemic Respiratory Failure Due to COVID-19 Open
With the COVID-19 pandemic, healthcare systems have been facing an unprecedented, large-scale respiratory disaster. Prone positioning improves mortality in severe hypoxemic respiratory failure, including COVID-19. While this is effective f…
View article: Continuous Neuromuscular Blockade Following Successful Resuscitation From Cardiac Arrest: A Randomized Trial
Continuous Neuromuscular Blockade Following Successful Resuscitation From Cardiac Arrest: A Randomized Trial Open
Background Neuromuscular blockade (NMB) agents are often administered to control shivering during targeted temperature management following cardiac arrest. In this study, we hypothesized that early, continuous NMB would result in a greater…
View article: COVID‐19 patient bridged to recovery with veno‐venous extracorporeal membrane oxygenation
COVID‐19 patient bridged to recovery with veno‐venous extracorporeal membrane oxygenation Open
With proper patient selection and careful attention to hemodynamic management, ECMO remains a reasonable treatment option for patients with COVID-19.
View article: Left ventricle unloading strategies in ECMO: A single‐center experience
Left ventricle unloading strategies in ECMO: A single‐center experience Open
Based on this analysis, reactive unloading appears to be a viable strategy while venting with the Impella CP provides better than anticipated survival. Our findings correlate with recent large cohort studies and motivate further work to de…
View article: COVID-19 Patient Bridged to Recovery with Veno-Venous Extracorporeal Membrane Oxygenation
COVID-19 Patient Bridged to Recovery with Veno-Venous Extracorporeal Membrane Oxygenation Open
Background: In severe cases, the COVID-19 viral pathogen produces hypoxic respiratory failure unable to be adequately supported by mechanical ventilation. The role of extracorporeal membrane oxygenation (ECMO) remains unknown, with the few…
View article: Venovenous Extracorporeal Membranous Oxygenation as Bridge-to-Diagnosis in Acute Respiratory Failure with Unknown Etiology - A Case Report
Venovenous Extracorporeal Membranous Oxygenation as Bridge-to-Diagnosis in Acute Respiratory Failure with Unknown Etiology - A Case Report Open
View article: Extracorporeal Membrane Oxygenation Resource Planning in the Setting of Pandemic Respiratory Illness
Extracorporeal Membrane Oxygenation Resource Planning in the Setting of Pandemic Respiratory Illness Open
View article: Equipoise in Appropriate Initial Volume Resuscitation for Patients in Septic Shock With Heart Failure: Results of a Multicenter Clinician Survey
Equipoise in Appropriate Initial Volume Resuscitation for Patients in Septic Shock With Heart Failure: Results of a Multicenter Clinician Survey Open
Purpose: International clinical practice guidelines call for initial volume resuscitation of at least 30 mL/kg body weight for patients with sepsis-induced hypotension or shock. Although not considered in the guidelines, preexisting cardia…
View article: Online_Supplement - Equipoise in Appropriate Initial Volume Resuscitation for Patients in Septic Shock With Heart Failure: Results of a Multicenter Clinician Survey
Online_Supplement - Equipoise in Appropriate Initial Volume Resuscitation for Patients in Septic Shock With Heart Failure: Results of a Multicenter Clinician Survey Open
Online_Supplement for Equipoise in Appropriate Initial Volume Resuscitation for Patients in Septic Shock With Heart Failure: Results of a Multicenter Clinician Survey by Gabriel Wardi, Ian Joel, Julian Villar, Michael Lava, Eric Gross, Vai…
View article: EAST Multicenter Trial on targeted temperature management for hanging-induced cardiac arrest
EAST Multicenter Trial on targeted temperature management for hanging-induced cardiac arrest Open
BACKGROUND We sought to determine the outcome of suicidal hanging and the impact of targeted temperature management (TTM) on hanging-induced cardiac arrest (CA) through an Eastern Association for the Surgery of Trauma (EAST) multicenter re…