Raghu S. Nagalingam
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View article: Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts Open
Background Mechanical stress and pathological signaling trigger the activation of fibroblasts to myofibroblasts, which impacts extracellular matrix composition, disrupts normal wound healing, and can generate deleterious fibrosis. Myocardi…
View article: Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts Open
1. Summary Mechanical stress and pathological signaling trigger the activation of fibroblasts to myofibroblasts, which impacts extracellular matrixcomposition, disrupts normal wound healing,andcan generate deleterious fibrosis (Bohl et al.…
View article: Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/− long QT syndrome variant
Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/− long QT syndrome variant Open
Aims Long QT syndrome type 2 (LQTS2) is associated with inherited variants in the cardiac human ether-à-go-go-related gene (hERG) K+ channel. However, the pathogenicity of hERG channel gene variants is often uncertain. Using CRISPR–Cas9 ge…
View article: Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C<sup>+/-</sup>During Development
Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C<sup>+/-</sup>During Development Open
Hypertrophic cardiomyopathy (HCM) is one of the most common heritable cardiovascular diseases and variants of TNNT2 (cardiac troponin T) are linked to increased risk of sudden cardiac arrest despite causing limited hypertrophy. In this stu…
View article: Scleraxis and fibrosis in the pressure-overloaded heart
Scleraxis and fibrosis in the pressure-overloaded heart Open
Aims In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present stud…
View article: Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis
Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis Open
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins. Little is known about the transcriptional control of energy metabolis…
View article: CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth
CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth Open
Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a trea…
View article: Scleraxis regulates Twist1 and Snai1 expression in the epithelial-to-mesenchymal transition
Scleraxis regulates Twist1 and Snai1 expression in the epithelial-to-mesenchymal transition Open
Numerous physiological and pathological events, from organ development to cancer and fibrosis, are characterized by an epithelial-to-mesenchymal transition (EMT), whereby adherent epithelial cells convert to migratory mesenchymal cells. Du…
View article: A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.
A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. Open
This article has been withdrawn by the authors. Lanes 1 and 2 of the actin immunoblot in Fig. 3B were reused in lanes 3 and 4 of the actin immunoblot in Fig. 7C. The ANF immunoblot in Fig. 3B was reused as ANF in Fig. 9F. Control lanes 1 a…
View article: Role of scleraxis in mechanical stretch-mediated regulation of cardiac myofibroblast phenotype
Role of scleraxis in mechanical stretch-mediated regulation of cardiac myofibroblast phenotype Open
The phenotype conversion of fibroblasts to myofibroblasts plays a key role in the pathogenesis of cardiac fibrosis. Numerous triggers of this conversion process have been identified, including plating of cells on solid substrates, cytokine…
View article: SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β Open
Tissue fibrosis is a major cause of organ dysfunction during chronic diseases and aging. A critical step in this process is transforming growth factor β1 (TGF-β1)-mediated transformation of fibroblasts into myofibroblasts, cells capable of…