Raghubendra Singh Dagur
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View article: Assessment of oral mucosal temperature as a diagnostic marker for systemic inflammation among dental patients
Assessment of oral mucosal temperature as a diagnostic marker for systemic inflammation among dental patients Open
Oral mucosal temperature as a non-invasive biomarker for systemic inflammation among 180 dental patients is of interest. Systemic inflammation in patients showed significantly higher mucosal temperatures (36.8 ± 0.7°C) than controls and lo…
View article: Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence
Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence Open
HIV-1 infection in the era of combined antiretroviral therapy has been associated with premature aging. Among the various features of HIV-1 associated neurocognitive disorders, astrocyte senescence has been surmised as a potential cause co…
View article: Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation
Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation Open
Recently, we found that both HIV and acetaldehyde, an alcohol metabolite, induce hepatocyte apoptosis, resulting in the release of large extracellular vesicles called apoptotic bodies (ABs). The engulfment of these hepatocyte ABs by hepati…
View article: Cell-to-Cell Communications in Alcohol-Associated Liver Disease
Cell-to-Cell Communications in Alcohol-Associated Liver Disease Open
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote en…
View article: Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium
Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium Open
View article: A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms
A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms Open
Progression of chronic infections to end‐stage diseases and poor treatment results are frequently associated with alcohol abuse. Alcohol metabolism suppresses innate and adaptive immunity leading to increased viral load and its spread. In …
View article: Ethanol attenuates presentation of cytotoxic T‐lymphocyte epitopes on hepatocytes of HBV‐infected humanized mice
Ethanol attenuates presentation of cytotoxic T‐lymphocyte epitopes on hepatocytes of HBV‐infected humanized mice Open
Background and Aims Approximately 3.5% of the global population is chronically infected with Hepatitis B Virus (HBV), which puts them at high risk of end‐stage liver disease, with the risk of persistent infection potentiated by alcohol con…
View article: Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells
Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells Open
Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde i…
View article: Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders
Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders Open
View article: Pancreatogenic Diabetes: Triggering Effects of Alcohol and HIV
Pancreatogenic Diabetes: Triggering Effects of Alcohol and HIV Open
Multiorgan failure may not be completely resolved among people living with HIV despite HAART use. Although the chances of organ dysfunction may be relatively low, alcohol may potentiate HIV-induced toxic effects in the organs of alcohol-ab…
View article: Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice
Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice Open
Background: Alcohol abuse is common in people living with HIV-1 and dramaticallyenhances the severity of HIV-induced liver damage by inducing oxidative stress and lysosomaldysfunction in the liver cells. We hypothesize that the increased r…
View article: Ethanol-HIV Stimulates Macrophage-derived Extracellular Vesicles to Promote a Profibrotic Phenotype in Hepatic Stellate Cells
Ethanol-HIV Stimulates Macrophage-derived Extracellular Vesicles to Promote a Profibrotic Phenotype in Hepatic Stellate Cells Open
Liver fibrosis is the scarring process where excessive extracellular matrix proteins occur and can be caused by exposure to certain toxins or compounds such as alcohol. Alcohol can lead to increased fibrosis and cirrhosis in people living …
View article: Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells
Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells Open
We conclude that by suppressing oxidative stress and restoring proteasomal and lysosomal functions impaired by HIV and ethanol metabolism, OCA decreases accumulation of HIV in hepatocytes, leading to down-regulation of apoptosis in these c…
View article: Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats
Neuronal‐derived extracellular vesicles are enriched in the brain and serum of HIV‐1 transgenic rats Open
Despite the efficacy of combination antiretroviral therapy (ART) in controlling human immunodeficiency virus (HIV‐1) replication, cytotoxic viral proteins such as HIV‐1 transactivator of transcription (Tat) persist in tissues such as the b…
View article: Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease
Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease Open
In an era of improved survival due to modern antiretroviral therapy, liver disease has become a major cause of morbidity and mortality, resulting in death in 15–17% of human immunodeficiency virus (HIV)-infected patients. Alcohol enhances …
View article: Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis Open
Despite the increased life expectancy of patients infected with human immunodeficiency virus-1 (HIV-1), liver disease has emerged as a common cause of their morbidity. The liver immunopathology caused by HIV-1 remains elusive. Small xenogr…
View article: Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics
Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics Open
View article: Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice
Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice Open
View article: Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection Open
View article: Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection Open
Background The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases, like HIV-1, and to investigate multiple aspects of human immune system develop…
View article: Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice Open
View article: Human hepatocytes depletion in the presence of HIV-1 infection in dual reconstituted humanized mice
Human hepatocytes depletion in the presence of HIV-1 infection in dual reconstituted humanized mice Open
HIV-1 infection impairs liver function, and liver diseases have become a leading cause of morbidity in infected patients. The immunopathology of liver damage caused by HIV-1 remains unclear. We used chimeric mice dually reconstituted with …
View article: Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism
Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism Open