Aisha Khan
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View article: ALIENATION AND ISOLATION IN MODERN, URBANIZED INDIA
ALIENATION AND ISOLATION IN MODERN, URBANIZED INDIA Open
This paper explores the psychological and sociological phenomena of alienation and isolation in the context of contemporary, urbanized India. With the rapid expansion of urban centers and the growing dominance of neoliberal economic models…
View article: Human Schwann Cell-Derived Extracellular Vesicle Isolation, Bioactivity Assessment, and Omics Characterization
Human Schwann Cell-Derived Extracellular Vesicle Isolation, Bioactivity Assessment, and Omics Characterization Open
The study establishes a robust framework for SCEV isolation and their comprehensive characterization, which is consistent with their therapeutic potential in neurological applications. This work provides a valuable proteomic, lipidomic, an…
View article: Non-high-density lipoprotein cholesterol: A marker of cardiovascular disease in Type-2 diabetes mellitus
Non-high-density lipoprotein cholesterol: A marker of cardiovascular disease in Type-2 diabetes mellitus Open
Objective: To determine association between serum Non-High-Density Lipoprotein cholesterol and cardiovascular disease in Type 2 Diabetes Mellitus patients. Material and Methods: This cross sectional, comparative study was carried out in co…
View article: Perioperative Risks and Outcomes in Asian American Patients with Type 2 Diabetes Mellitus and/or Metabolic Syndrome: a Systematic Scoping Review
Perioperative Risks and Outcomes in Asian American Patients with Type 2 Diabetes Mellitus and/or Metabolic Syndrome: a Systematic Scoping Review Open
Asian Americans (AA) have an increased risk of developing type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) compared to non-Hispanic White Americans, yet over half of AA patients with T2DM are underdiagnosed or untreated. Surgi…
View article: Pakistan’s Foreign Policy: A Comparative Analysis of Isolation in the 1990s and the Contemporary Era
Pakistan’s Foreign Policy: A Comparative Analysis of Isolation in the 1990s and the Contemporary Era Open
Pakistan's foreign policy during the 1990s navigated a complex global landscape marked by post-Cold War uncertainties and regional realignments, resulting in a degree of international isolation. This research examines this period, analyzin…
View article: Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model
Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model Open
Peripheral nerve injury (PNI) is characterized by a loss of cellular and axonal integrity, often leading to limited functional recovery and pain. Many PNIs are not amenable to repair with traditional techniques; however, cell therapies, pa…
View article: Assessing Survival, Distribution, and Optimal Loading Technique of Schwann Cell–Derived Exosomes Into Second-generation Axon Guidance Channels
Assessing Survival, Distribution, and Optimal Loading Technique of Schwann Cell–Derived Exosomes Into Second-generation Axon Guidance Channels Open
Introduction Peripheral nerve injury (PNI) occurs in approximately 3% of all trauma patients and can be challenging to treat, particularly when injury is severe such as with a long-segmental gap. Although peripheral nerves can regenerate a…
View article: Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury Open
Bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment are among the most common morbidities affecting preterm infants. Although BPD is a predictor of poor neurodevelopmental outcomes, it is currently uncertain how BPD contribu…
View article: Treating amyotrophic lateral sclerosis with allogeneic Schwann cell–derived exosomal vesicles: a case report
Treating amyotrophic lateral sclerosis with allogeneic Schwann cell–derived exosomal vesicles: a case report Open
Schwann cells are essential for the maintenance and function of motor neurons, axonal networks, and the neuromuscular junction. In amyotrophic lateral sclerosis, where motor neuron function is progressively lost, Schwann cell function may …
View article: Beneficial Effects of Human Schwann Cell-Derived Exosomes in Mitigating Secondary Damage After Penetrating Ballistic-Like Brain Injury
Beneficial Effects of Human Schwann Cell-Derived Exosomes in Mitigating Secondary Damage After Penetrating Ballistic-Like Brain Injury Open
There is a growing body of evidence that the delivery of cell-derived exosomes normally involved in intracellular communication can reduce secondary injury mechanisms after brain and spinal cord injury and improve outcomes. Exosomes are na…
View article: (228) Cell-Based Therapy Can Restore Erectile Function in Men with Type 2 Diabetes and Metabolic Syndrome by Promoting Angiogenesis and Endothelial Repair
(228) Cell-Based Therapy Can Restore Erectile Function in Men with Type 2 Diabetes and Metabolic Syndrome by Promoting Angiogenesis and Endothelial Repair Open
Introduction Although there has been a growing interest in restorative therapies for erectile dysfunction (ED) in recent years, there is still limited mechanistic evidence to support their effectiveness in the clinical setting. Objective T…
View article: Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy
Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy Open
Background Although cell therapy provides benefits for outcomes of heart failure, the most optimal cell type to be used clinically remains unknown. Most of the cell products used for therapy in humans require in vitro expansion to obtain a…
View article: COMPARISON OF SAME DAY POLYETHYLENE GLYCOL REGIMEN VS SPLIT DOSE POLYETHYLENE GLYCOL REGIMEN FOR COLONOSCOPY
COMPARISON OF SAME DAY POLYETHYLENE GLYCOL REGIMEN VS SPLIT DOSE POLYETHYLENE GLYCOL REGIMEN FOR COLONOSCOPY Open
Colonoscopy is a procedure which depends upon the quality of bowel preparation. Polyethylene glycol(PEG) is commonly used laxative for bowel preparation. The method of PEG administration affects the quality of bowel preparation. We designe…
View article: The impact of cell-based therapy on female sexual dysfunction: a systematic review and meta-analysis
The impact of cell-based therapy on female sexual dysfunction: a systematic review and meta-analysis Open
Introduction Female sexual dysfunction (FSD) is a complex issue affecting women of all ages; it involves several overlapping body systems and profoundly affects quality of life. The use of cell-based therapy, such as mesenchymal stem cells…
View article: HIV Promotes Atherosclerosis via Circulating Extracellular Vesicle MicroRNAs
HIV Promotes Atherosclerosis via Circulating Extracellular Vesicle MicroRNAs Open
People living with HIV (PLHIV) are at a higher risk of having cerebrocardiovascular diseases (CVD) compared to HIV negative (HIVneg) individuals. The mechanisms underlying this elevated risk remains elusive. We hypothesize that HIV infecti…
View article: A Novel Therapy for ALS: Allogeneic Schwann Cell Extracellular Vesicles
A Novel Therapy for ALS: Allogeneic Schwann Cell Extracellular Vesicles Open
Summary Amyotrophic Lateral Sclerosis (ALS) is a terminal condition with accelerated loss of motor neurons (MN), resulting in the progressive paralysis of affected patients. ALS is either sporadic (90%) or genetically transmitted (10%) and…
View article: Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial
Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial Open
Aims Hypoplastic left heart syndrome (HLHS) survival relies on surgical reconstruction of the right ventricle (RV) to provide systemic circulation. This substantially increases the RV load, wall stress, maladaptive remodelling, and dysfunc…
View article: Intramyocardial cell-based therapy during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: The ELPIS phase I trial
Intramyocardial cell-based therapy during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: The ELPIS phase I trial Open
Background Hypoplastic left heart syndrome (HLHS) survival relies on surgical reconstruction for the right ventricle (RV) to provide systemic circulation. This leads to substantially increased loads on the RV, wall stress, maladaptive remo…
View article: Prevalence and Determinants of Mental Health Problems and Mental Health Stigma Among Medical Students of Different Nationalities in Qatar
Prevalence and Determinants of Mental Health Problems and Mental Health Stigma Among Medical Students of Different Nationalities in Qatar Open
In addition to the impact of the requirements of medical study, the high prevalence of reported mental illness among medical students is impacted by sociodemographic factors and the mental health stigma that constitutes a barrier to seekin…
View article: Optimal Technique for Introducing Schwann Cells Into Peripheral Nerve Repair Sites
Optimal Technique for Introducing Schwann Cells Into Peripheral Nerve Repair Sites Open
Peripheral nerve injury (PNI) is found in a relatively large portion of trauma patients. If the injury is severe, such as with the presence of a long segmental gap, PNI can present a challenge for treatment. The current clinical standard o…
View article: Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension
Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmonary Dysplasia Complicated By Pulmonary Hypertension Open
Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models. The optimal source, dosing, route, and duration of effects are however u…