Md Niaz Rahim
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View article: Epitranscriptomics: Unveiling RNA Modifications as Regulators of Cellular Fate
Epitranscriptomics: Unveiling RNA Modifications as Regulators of Cellular Fate Open
Epitranscriptomics, the study of RNA modifications, has emerged as a critical field in understanding the regulation of gene expression and cellular function. RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), ps…
View article: Immobilization of Bacillus-Derived Pectinase on Agarose Beads for Improved Catalytic Performance
Immobilization of Bacillus-Derived Pectinase on Agarose Beads for Improved Catalytic Performance Open
Pectinase catalyzes the depolymerization of pectin polymer into galacturonic acid and is utilized in various industrial applications. In the current study, pectinase from Bacillus species was encapsulated in agarose beads using the entrapm…
View article: A Pan-Ebolavirus Monoclonal Antibody Cocktail Provides Protection Against Ebola and Sudan Viruses
A Pan-Ebolavirus Monoclonal Antibody Cocktail Provides Protection Against Ebola and Sudan Viruses Open
Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal disease in humans. Over the past several years, antibody therapy has emerged as a promising strategy for the treatment of filovirus disease. Here, we …
View article: WORKING CAPITAL MANAGEMENT OF ASHOK LEYLAND LTD
WORKING CAPITAL MANAGEMENT OF ASHOK LEYLAND LTD Open
This paper examines the impact of working capital management of selected automobile industries in India.Objective of the study is to analyze the working capital position of selected automobile industries in India.For this purpose a sample …
View article: Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability Open
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this …
View article: Characterization of Ebola Virus Risk to Bedside Providers in an Intensive Care Environment
Characterization of Ebola Virus Risk to Bedside Providers in an Intensive Care Environment Open
Background: The 2014–2016 Ebola outbreak in West Africa recapitulated that nosocomial spread of Ebola virus could occur and that health care workers were at particular risk including notable cases in Europe and North America. These instanc…
View article: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model
Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model Open
Background There are currently limited data for the use of specific antiviral therapies for the treatment of Ebola virus disease (EVD). While there is anecdotal evidence that supportive care may be effective, there is a paucity of direct e…
View article: Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies
Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies Open
Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication. To generate anti-filovirus monoclonal antibodies (mAbs) against…
View article: Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine
Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine Open
There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines a…
View article: Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation
Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation Open
Influenza A virus (IAV) infections remain a major human health threat. IAV has enormous genetic plasticity and can rapidly escape virus-targeted anti-viral strategies. Thus, there is increasing interest to identify host proteins and proces…
View article: Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease
Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease Open
EBOV is one of the deadliest viruses to humans. It has been over 40 years since EBOV was first reported, but no cure is available. Research breakthroughs over the past 5 years have shown that MAbs constitute an effective therapy for EBOV i…
View article: Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates
Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates Open
All available experimental vaccines and immunotherapeutics 1,2 against Ebola virus (EBOV), including rVSV-ZEBOV 3 and ZMapp TM4 , lack activity against other ebolaviruses associated with human disease outbreaks. This year, two separate out…
View article: Postexposure Protective Efficacy of T-705 (Favipiravir) Against Sudan Virus Infection in Guinea Pigs
Postexposure Protective Efficacy of T-705 (Favipiravir) Against Sudan Virus Infection in Guinea Pigs Open
Filoviruses such as Ebola virus (EBOV), Marburg virus (MARV), and Sudan virus (SUDV) cause deadly viral hemorrhagic fever in humans, with high case-fatality rates; however, no licensed therapeutic agent or vaccine has been clinically appro…
View article: Autophagy activation is required for influenza A virus-induced apoptosis and replication
Autophagy activation is required for influenza A virus-induced apoptosis and replication Open
Autophagy and apoptosis are two major interconnected host cell responses to viral infection, including influenza A virus (IAV). Thus, delineating these events could facilitate the development of better treatment options and provide an effe…
View article: Occurrence of Hybrid Escherichia coli Strains Carrying Shiga Toxin and Heat-Stable Toxin in Livestock of Bangladesh
Occurrence of Hybrid Escherichia coli Strains Carrying Shiga Toxin and Heat-Stable Toxin in Livestock of Bangladesh Open
Shiga toxin-producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) are important causes of diarrhea in humans and animals worldwide. Although ruminant animals are the main source of STEC, diarrhea due to this pathotype is ver…
View article: Identification of host cellular factors that interact with Influenza A NS1 protein for viral replication
Identification of host cellular factors that interact with Influenza A NS1 protein for viral replication Open
Influenza A virus (IAV) is considered one of the main threats that causes
\ncontagious respiratory disease in humans. Each year it threatens the human population
\nwith epidemics and pandemics. Limited anti-Influenza drugs are available th…