Rahul Bhatnagar
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View article: A patient-centred approach to malignant pleural effusion
A patient-centred approach to malignant pleural effusion Open
The treatment of MPE has changed in the last 15 years to focus on outpatient management and symptom control. Careful discussions must be undertaken on a patient-by-patient basis.
View article: Patient and Procedural Factors Associated With Insufficient Office Endometrial Biopsy
Patient and Procedural Factors Associated With Insufficient Office Endometrial Biopsy Open
OBJECTIVE: To identify patient-specific and procedural factors associated with insufficient office endometrial biopsy. METHODS: We conducted a large retrospective cohort study of adult patients who underwent office endometrial biopsy in 20…
View article: Characteristics and predictors of clinical outcome in patients with pleural effusions caused by heart, liver and renal failure: results from the ERS International Multicentre Pleural Research Collaborative (IMPACT) registry
Characteristics and predictors of clinical outcome in patients with pleural effusions caused by heart, liver and renal failure: results from the ERS International Multicentre Pleural Research Collaborative (IMPACT) registry Open
Introduction Pleural effusions caused by organ dysfunction are the commonest pleural disease and account for a huge healthcare burden. Previous work has demonstrated poor survival rates, but there is still uncertainty about determinants of…
View article: Secretoneurin Concentrations Measured with a High-Throughput Assay and Clinical Outcomes in Patients Hospitalized with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
Secretoneurin Concentrations Measured with a High-Throughput Assay and Clinical Outcomes in Patients Hospitalized with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study Open
Background High-throughput assays are required for novel biomarkers to have clinical potential. Secretoneurin (SN) is a candidate biomarker, and the performance of a new high-throughput SN assay is not known. Methods We measured SN concent…
View article: Diagnostic Accuracy of Shear Wave Elastography in Predicting Malignant Origins of Pleural Effusions in Emergency Departments
Diagnostic Accuracy of Shear Wave Elastography in Predicting Malignant Origins of Pleural Effusions in Emergency Departments Open
Objective: Ultrasound is a valuable diagnostic tool in the diagnostic work-up of dyspnea and can identify even small pleural effusions. The incorporation of shear wave elastography (SWE) represents a possible tool in stratifying pleural ef…
View article: Associations between Chest Pain, Diagnosis, and Clinical Outcome in Patients Hospitalized with Acute Dyspnea: Data from the ACE 2 Study
Associations between Chest Pain, Diagnosis, and Clinical Outcome in Patients Hospitalized with Acute Dyspnea: Data from the ACE 2 Study Open
Introduction: Patients hospitalized due to dyspnea sometimes also report concomitant chest pain. Whether co-existing chest pain in patients with acute dyspnea associates with specific diagnosis and clinical outcome is not known. Method: We…
View article: Con: indwelling pleural catheters cause harm to patients
Con: indwelling pleural catheters cause harm to patients Open
Indwelling pleural catheters (IPCs) have rapidly grown in popularity since their introduction for the management of recurrent pleural effusions. In malignant pleural effusions especially, there has been a shift away from measuring pleurode…
View article: Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement
Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement Open
Background Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased healthspan. With advancing age, the increased prevalence of ageing-related diseases can have a significant…
View article: Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study
Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study Open
Background: Malignant pleural effusion (MPE) affects up to 15% of patients with malignancy, and the prevalence is increasing. Non-expandable lung (NEL) complicates MPE in up to 30% of cases. However, it is not known if patients with malign…
View article: Advances in the diagnosis and follow-up of pleural lesions: a scoping review
Advances in the diagnosis and follow-up of pleural lesions: a scoping review Open
Despite the recent advances in the field, there are several key areas for improvement, including the development and validation of minimal invasive methods and tools for risk stratification, the integration of multi-omics technologies, the…
View article: Ultrasound in predicting improvement in dyspnoea after therapeutic thoracentesis in patients with recurrent unilateral pleural effusion
Ultrasound in predicting improvement in dyspnoea after therapeutic thoracentesis in patients with recurrent unilateral pleural effusion Open
In our study population, US-characteristics including assessment of diaphragm movement or shape was not associated with a minimal important improvement in dyspnoea immediately following thoracentesis.
View article: Ultrasound in the Diagnosis of Non-Expandable Lung: A Prospective Observational Study of M-Mode, B-Mode, and 2D-Shear Wave Elastography
Ultrasound in the Diagnosis of Non-Expandable Lung: A Prospective Observational Study of M-Mode, B-Mode, and 2D-Shear Wave Elastography Open
Background: Non-expandable lung (NEL) has severe implications for patient symptoms and impaired lung function, as well as crucial implications for the management of malignant pleural effusion (MPE). Indwelling pleural catheters have shown …
View article: Erratum: Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Erratum: Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion Open
An erratum was issued for: Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion. The Authors section was updated from: Uffe Bodtger1,2 José M. Porcel3 Rahul Bhatnagar4,5 Mohammed Munavvar6,7<…
View article: The European Respiratory Society led training programme improves self-reported competency and increases the use of thoracic ultrasound
The European Respiratory Society led training programme improves self-reported competency and increases the use of thoracic ultrasound Open
Thoracic ultrasound has become a well-implemented diagnostic tool for assessment and monitoring of patients with respiratory symptoms or disease. However, ultrasound examinations are user dependent and sufficient competencies are needed. T…
View article: S11 Serial sampling for novel biomarker evaluation in malignant pleural effusion: the predictive potential of pleural fluid suPAR
S11 Serial sampling for novel biomarker evaluation in malignant pleural effusion: the predictive potential of pleural fluid suPAR Open
Introduction and Objectives Soluble urokinase plasminogen activator receptor (suPAR) is a novel inflammatory biomarker with predictive potential for invasive management in loculated parapneumonic effusions.1 We sought to explore…
View article: Comparison of international guideline recommendations for the diagnosis of pulmonary embolism
Comparison of international guideline recommendations for the diagnosis of pulmonary embolism Open
View article: Clinical characteristics of chylothorax: results from the International Collaborative Effusion database
Clinical characteristics of chylothorax: results from the International Collaborative Effusion database Open
Background Chylothorax is an uncommon medical condition for which limited data are available regarding the contemporary aetiology, management and outcomes. The goal of this study was to better define these poorly characterised features. Me…
View article: British Thoracic Society Clinical Statement on pleural procedures
British Thoracic Society Clinical Statement on pleural procedures Open
of clInIcal practIce poIntS Safety and preparation for pleural procedures► Before carrying out a pleural procedure, safety and preparation should be taken into consideration. Research questions• Studies to investigate the role of fibrinoly…
View article: Evidence-based training and certification: the ERS thoracic ultrasound training programme
Evidence-based training and certification: the ERS thoracic ultrasound training programme Open
Thoracic ultrasound has developed into an integral part of the respiratory physician's diagnostic and therapeutic toolbox, with high diagnostic accuracy for many diseases causing acute or chronic respiratory symptoms. However, it is vitall…
View article: The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): study protocol for a randomised controlled trial
The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): study protocol for a randomised controlled trial Open
Introduction Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and o…
View article: Lung Ultrasound to Assess Pulmonary Congestion in Patients with Acute Exacerbation of COPD
Lung Ultrasound to Assess Pulmonary Congestion in Patients with Acute Exacerbation of COPD Open
LUS did not detect concurrent HF or predict risk in patients with AECOPD.
View article: Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database
Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database Open
Introduction We present findings from the International Collaborative Effusion database, a European Respiratory Society clinical research collaboration. Nonspecific pleuritis (NSP) is a broad term that describes chronic pleural inflammatio…
View article: Objective structured clinical examination in basic thoracic ultrasound: a European study of validity evidence
Objective structured clinical examination in basic thoracic ultrasound: a European study of validity evidence Open
View article: Supplementary Material for: Prediction of Time to Next Therapeutic Thoracentesis and Identification of Risk Factors of Rapid Pleural Fluid Recurrence: A Prospective Observational Study
Supplementary Material for: Prediction of Time to Next Therapeutic Thoracentesis and Identification of Risk Factors of Rapid Pleural Fluid Recurrence: A Prospective Observational Study Open
Background: The value of pre-booked repeated thoracentesis in patients with recurrent pleural effusion is reliant on the estimation of time to next drainage. Identifying factors associated with rapid pleural fluid recurrence …
View article: Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study Open
Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day…
View article: Additional Up-Front Thoracic Ultrasound in the Workup of Patients with Unilateral Pleural Effusion: A Prospective Observational Pilot Study
Additional Up-Front Thoracic Ultrasound in the Workup of Patients with Unilateral Pleural Effusion: A Prospective Observational Pilot Study Open
Background: In patients with pleural effusion, specific ultrasound characteristics are associated with pleural malignancy. Objectives: This study aimed to evaluate the added value of an additional, up-front, systematic thoracic ultrasound …
View article: Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study
Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study Open
Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day…
View article: Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study
Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study Open
Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day…
View article: Supplementary Material for: Additional upfront thoracic ultrasound in the workup of patients with unilateral pleural effusion: A prospective observational pilot study.
Supplementary Material for: Additional upfront thoracic ultrasound in the workup of patients with unilateral pleural effusion: A prospective observational pilot study. Open
Background: In patients with pleural effusion, specific ultrasound characteristics are associated with pleural malignancy. Objectives: This study aims to evaluate the added value of an additional, up-front, systematic thoracic ultrasound (…
View article: Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study
Supplementary Material for: Cardiac troponin T and NT-proBNP for prediction of 30-day readmission or death in patients with acute dyspnea: Data from the Akershus Cardiac Examination 2 Study Open
Introduction: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day…