Rahul K. Lall
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View article: Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy
Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy Open
Background Anthracyclines such as doxorubicin (Dox) are highly effective anti-tumor agents, but their use is limited by dose-dependent cardiomyopathy and heart failure. Our laboratory previously reported that induction of cytochrome P450 f…
View article: Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice
Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice Open
Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast cancer could identify new mechanisms of anthracycline cardiac …
View article: <p>What are the links between hypoxia and Alzheimer’s disease?</p>
What are the links between hypoxia and Alzheimer’s disease? Open
Alzheimer's disease (AD) is the most common neurodegenerative disease. Histological characterization of amyloid plaques and neurofibrillary tangles in the brains of AD patients, alongside genetic studies in individuals suffering the famili…
View article: Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis
Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis Open
We and others have shown previously that fisetin, a plant flavonoid, has therapeutic potential against many cancer types. Here, we examined the probable mechanism of its action in prostate cancer (PCa) using a global metabolomics approach.…
View article: Dietary flavonoid fisetin for cancer prevention and treatment
Dietary flavonoid fisetin for cancer prevention and treatment Open
Cancer remains a major public health concern and a significant cause of death worldwide. Identification of bioactive molecules that have the potential to inhibit carcinogenesis continues to garner interest among the scientific community. I…
View article: Potent Anti-Proliferative, Pro-Apoptotic Activity of the Maytenus Royleanus Extract against Prostate Cancer Cells: Evidence in In-Vitro and In-Vivo Models
Potent Anti-Proliferative, Pro-Apoptotic Activity of the Maytenus Royleanus Extract against Prostate Cancer Cells: Evidence in In-Vitro and In-Vivo Models Open
Prostate cancer is a leading of cause of cancer related death in men. Despite intensive investment in improving early diagnosis, it often escapes timely detection. Mortality remains high in advanced stage prostate cancer where palliative c…
View article: Dietary Polyphenols in Prevention and Treatment of Prostate Cancer
Dietary Polyphenols in Prevention and Treatment of Prostate Cancer Open
Prostate cancer is the most prevalent disease affecting males in many Western countries, with an estimated 29,480 deaths in 2014 in the US alone. Incidence rates for prostate cancer deaths have been decreasing since the early 1990s in men …
View article: Role of Epithelial Mesenchymal Transition in Prostate Tumorigenesis
Role of Epithelial Mesenchymal Transition in Prostate Tumorigenesis Open
Globally, the cancer associated deaths are generally attributed to the spread of cancerous cells or their features to the nearby or distant secondary organs by a process known as metastasis. Among other factors, the metastatic disseminatio…