Rahul Patil
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View article: 3D Peri-Implant Epi-Mucosa-on-a-Chip Reveals Alterations in Epithelial Barrier Function Mediated by Host-Bacteria-Biomaterial Interactions
3D Peri-Implant Epi-Mucosa-on-a-Chip Reveals Alterations in Epithelial Barrier Function Mediated by Host-Bacteria-Biomaterial Interactions Open
Peri-implantitis is characterized by disruption of the epithelial barrier at the implant-mucosa interface, driven by complex interactions between mechanical, microbial, and material factors. Histological and immunohistochemical analysis of…
View article: Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation
Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation Open
Osteoporosis is a prevalent skeletal disorder characterized by decreased bone mass and structural deterioration, leading to an increased risk of fractures. This study focuses on the regulatory role of Vitamin C (ascorbic acid; AA) in the c…
View article: Peripheral Intravenous Catheter Failure in Hospitalized Patients: Bridging the Gap between Microbiological Data and Clinical Indicators and possible relevance to therapeutic targets
Peripheral Intravenous Catheter Failure in Hospitalized Patients: Bridging the Gap between Microbiological Data and Clinical Indicators and possible relevance to therapeutic targets Open
The peripheral intravenous catheter (PIC) is most commonly used invasive technology among inpatients, frequently associated with hospital procedures worldwide. However, PIC insertion presents multiple challenges, particularly the risk for …
View article: Osteoarthritis Management Reimagined: Bridging Traditional Therapies with Nanotechnology and Personalized Medicine for Better Outcomes
Osteoarthritis Management Reimagined: Bridging Traditional Therapies with Nanotechnology and Personalized Medicine for Better Outcomes Open
Osteoarthritis (OA) is a leading cause of pain and disability worldwide, profoundly affecting patients’ mobility and quality of life. Traditional management strategies—such as nonsteroidal anti-inflammatory drugs, corticosteroid injections…
View article: Abstract 2377 Clickable small molecule-fluorophore development for bioimaging applications
Abstract 2377 Clickable small molecule-fluorophore development for bioimaging applications Open
View article: Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention Open
Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria thro…
View article: Navigating Challenges: PTMC in people living with HIV with Severe Mitral Stenosis
Navigating Challenges: PTMC in people living with HIV with Severe Mitral Stenosis Open
View article: Graphene in 3D Bioprinting
Graphene in 3D Bioprinting Open
Three-dimensional (3D) bioprinting is a fast prototyping fabrication approach that allows the development of new implants for tissue restoration. Although various materials have been utilized for this process, they lack mechanical, electri…
View article: DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc <sub>1</sub>
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc <sub>1</sub> Open
New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new chemical entities that are suitable for clinical develop…
View article: A Comprehensive Review of The Impact of Quench Nozzles on Pressure Vessel Design
A Comprehensive Review of The Impact of Quench Nozzles on Pressure Vessel Design Open
This research examines the influence of cooling spout positioning on pressure container blueprints, particularly emphasizing strain features. Sprayers are crucial for ingress and egress objectives in force containers, and although maximum …
View article: Antimalarial Dibenzannulated Medium-Ring Keto Lactams
Antimalarial Dibenzannulated Medium-Ring Keto Lactams Open
We discovered dibenzannulated medium-ring keto lactams (11,12-dihydro-5H-dibenzo[b,g]azonine-6,13-diones) as a new antimalarial chemotype. Most of these had chromatographic LogD7.4 values ranging from 100 μg…
View article: Variable neutralizing antibody responses to 10 SARS-CoV-2 variants in natural infection with wild- type (B.1) virus, Kappa (B.1.617.1), and Delta (B.1.617.2) variants and COVISHIELD vaccine immunization in India: utility of the MSD platform
Variable neutralizing antibody responses to 10 SARS-CoV-2 variants in natural infection with wild- type (B.1) virus, Kappa (B.1.617.1), and Delta (B.1.617.2) variants and COVISHIELD vaccine immunization in India: utility of the MSD platform Open
For the efficacy of COVID-19 vaccines, emergence of variants accumulating immune-escape mutations remains a major concern. We analyzed the anti-variant (n = 10) neutralization activity of sera from COVID-19 patients infected with Wuhan (B.…
View article: Engineered exosomes for cancer theranostics: Next-generation tumor targeting
Engineered exosomes for cancer theranostics: Next-generation tumor targeting Open
Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are best known for their function in mediating intercellular connectivity by transferring various biom…
View article: Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers
Depth of Invasion, Lymphovascular Invasion, and Perineural Invasion as Predictors of Neck Node Metastasis in Early Oral Cavity Cancers Open
View article: Variation of Cost Among Oral Hypoglycaemic Drugs Available in Indian Market in 2020-21
Variation of Cost Among Oral Hypoglycaemic Drugs Available in Indian Market in 2020-21 Open
In the absence of comparative information on hypoglycaemic drug prices, it is difficult for physicians to prescribe most economical treatment. Hence, this study is designed to analyse the percentage variation of cost among different brands…
View article: Comparison And Evaluation Of Drought Indices Using Analytical Hierarchy Process (Ahp) Over Raichur District, Karnataka
Comparison And Evaluation Of Drought Indices Using Analytical Hierarchy Process (Ahp) Over Raichur District, Karnataka Open
The Raichur district is considered as a drought prone area in Karnataka. The study was carried out to compare and evaluate the performance of six drought indices in the study area namely Standardized precipitation index (SPI), Standardized…
View article: 2D Echocardiographic Findings, NT-ProBNP Levels, and Outcomes in Dyspnoeic Patients: Results from the Pro-BNP Investigation of Dyspnoea in the Emergency Department- a Single Centre Experience
2D Echocardiographic Findings, NT-ProBNP Levels, and Outcomes in Dyspnoeic Patients: Results from the Pro-BNP Investigation of Dyspnoea in the Emergency Department- a Single Centre Experience Open
Background: Dyspnoeic in the emergency department with multiple co-morbidities is a diagnostic challenge. Approximately 15-20% of acute dyspneic in the Emergency Department due to ADHF (acute decompensated heart failure) are misdiagnosed. …
View article: ULK1/2 Inhibitor: Essential Component of Autophagic Cell Death Machinery
ULK1/2 Inhibitor: Essential Component of Autophagic Cell Death Machinery Open
The effectiveness of selective drug therapy for cancer patients has gained much attention from academics and society. However, the rapid development of the drug resistance gained is becoming a significant challenge. As an essential catabol…
View article: Immunogenicity of two COVID-19 vaccines used in India: An observational cohort study in health care workers from a tertiary care hospital
Immunogenicity of two COVID-19 vaccines used in India: An observational cohort study in health care workers from a tertiary care hospital Open
COVID-19 pandemic witnessed rapid development and use of several vaccines. In India, a country-wide immunization was initiated in January 2021. COVISHIELD, the chimpanzee adenoviral-vectored vaccine with full-length SARS-COV-2 spike insert…
View article: Survival outcomes for patients with nasopharyngeal carcinoma in non–endemic region in the UK treated with intensity modulated based radiotherapy 65 Gy in 30 fractions ± weekly cisplatin chemotherapy
Survival outcomes for patients with nasopharyngeal carcinoma in non–endemic region in the UK treated with intensity modulated based radiotherapy 65 Gy in 30 fractions ± weekly cisplatin chemotherapy Open
To the best of authors' knowledge, this is the first report of the use of 65 Gy in 30 fractions of radiotherapy ± weekly cisplatin chemotherapy in NPC in a real-world setting. Our results are comparable to that from other non-endemic regio…
View article: Design of Foundation for 220 kV Electrical Substation on Black Cotton Soil
Design of Foundation for 220 kV Electrical Substation on Black Cotton Soil Open
The design on black cotton soil has always been a difficult task for the engineers because the structure resting on black cotton soil cracks with none warning. Black cotton soil is found in M.P., Karnataka, Maharashtra and Andhra Pradesh i…
View article: Relation of Physical Fitness Index with Body Mass Index: Study Among Female Students of Balwant College Vita, Dist. Sangli, (M.S.), India
Relation of Physical Fitness Index with Body Mass Index: Study Among Female Students of Balwant College Vita, Dist. Sangli, (M.S.), India Open
The present study was undertaken to find out the correlation between Physical Fitness Index (PFI) and Body Mass Index (BMI). Physical Fitness Index was measured using the Modified Harvard step test. BMI was calculated by the Quetelet Index…
View article: Influence of Catalase Encapsulation on Cobalt@Nanoporous Carbon with Multiwall Shell for Supercapacitor and Polyurethane Synthesis by Using Carbon Dioxide
Influence of Catalase Encapsulation on Cobalt@Nanoporous Carbon with Multiwall Shell for Supercapacitor and Polyurethane Synthesis by Using Carbon Dioxide Open
View article: Assessment of Reliability of Advanced Lipid Parameters for Premature Coronary Artery Disease in Young Indians: A Case-control Study
Assessment of Reliability of Advanced Lipid Parameters for Premature Coronary Artery Disease in Young Indians: A Case-control Study Open
Introduction: Coronary Artery Disease (CAD) appears even in patients with normal level of conventional lipid parameters. But due to lack of specific guidelines on Indian population, involving detection of advanced lipid indices, has result…
View article: Two-Dimensional Loading in Vehicle Routing Problem With Release and Due Dates
Two-Dimensional Loading in Vehicle Routing Problem With Release and Due Dates Open
In this paper, we study a two-dimensional vehicle loading and routing problem, in which customer orders with deadlines become available for dispatch as per their release dates. The objective is to minimize the sum of transportation, invent…
View article: Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series Open
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 (1) suggested that DHODH inhibitors have great pot…
View article: Sustainability Transition in Established Corporations: Detailing the Role of Technological Innovation
Sustainability Transition in Established Corporations: Detailing the Role of Technological Innovation Open
Sustainability transition theories analyse a systematic shift towards sustainability at micro (niche), meso (regime) and macro (landscape) level. The assessment of technological systems and structures at the firm level in sustainability tr…
View article: Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1
Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1 Open
View article: Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion
Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion Open
Graphene oxide (GO) nanosheet suspension is not stable in physiological ionic fluids. To improve stability, surfactants such as Pluronic 103 (P103) have been tested. Going further, this work investigated whether conferring positive surface…
View article: Modulation of Lymphocyte Potassium Channel K<sub>V</sub>1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
Modulation of Lymphocyte Potassium Channel K<sub>V</sub>1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin Open
We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable peptide, EgK5, that modulates voltage-gated KV1.3 potassium channels in T lymphocytes by a distinctive mechanism. EgK5 enters plasma membr…