Rahul Sreekumar
YOU?
Author Swipe
View article: Oro Facial Herpes Zoster: A Case Report
Oro Facial Herpes Zoster: A Case Report Open
Herpes zoster or shingles is a re activation of the Varicella zoster that entered the cutaneous nerve endings during an earlier episode of chicken pox, travelled to the dorsal root ganglia, and remained in a latent form. Nerves most common…
View article: Langerhans Histiocytosis Mimicking Aggressive Periodontitis in Adult: A Rare Case Report
Langerhans Histiocytosis Mimicking Aggressive Periodontitis in Adult: A Rare Case Report Open
A BSTRACT Langerhans cell histiocytosis (LCH), also known as histiocytosis X, is a rare condition characterized by neoplastic proliferation of histiocytes and other inflammatory cells leading to the accumulation and pathological disseminat…
View article: ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage
ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage Open
DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the earliest DNA repair mechanisms, functionally conserved from bacteria to human. The fact th…
View article: The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes <i>ERCC1</i> and <i>ERCC4</i> in colorectal cancer
The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes <i>ERCC1</i> and <i>ERCC4</i> in colorectal cancer Open
Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of an epithelial to mesenchymal transition (EMT)‐inducing protein, ZEB2, in chemor…
View article: Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC
Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC Open
View article: Assessment of Nuclear ZEB2 as a Biomarker for Colorectal Cancer Outcome and TNM Risk Stratification
Assessment of Nuclear ZEB2 as a Biomarker for Colorectal Cancer Outcome and TNM Risk Stratification Open
The findings suggest that expression of ZEB2 is associated with poor oncologic outcome and distant recurrence. The study also found that the addition of ZEB2 to existing TNM classification improved the ability to stratify patients for risk…
View article: SIP1/ZEB2 induced epthelial to mesenchymal transition promotes metastasis and chemoresistance in colorectal cancer
SIP1/ZEB2 induced epthelial to mesenchymal transition promotes metastasis and chemoresistance in colorectal cancer Open
Colorectal cancer (CRC) is the second commonest cause of cancer-associated mortality in Europe, and a key public health issue. Cancer metastasis is the principle cause of death and occurs in up to 30% at presentation, and subsequently deve…