Rahul Ukey
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View article: Live microbials to boost Anti-SARS-CoV-2 immunity clinical trial (Live BASIC trial): a triple-blind randomized controlled trial
Live microbials to boost Anti-SARS-CoV-2 immunity clinical trial (Live BASIC trial): a triple-blind randomized controlled trial Open
Purpose With waning immunity and vaccine hesitancy, the COVID-19 pandemic continues to pose risks. A live microbial consortium (OL-1) with bacteria containing potentially cross-reactive antigens (CRAGs) stimulates anti-SARS-CoV-2 immune re…
View article: Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection
Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection Open
Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children (MIS-C), characterized by hyperinflammation and multi-…
View article: Validation of the Diabetomics CovAB SARS-CoV-2 antibody test in children: comparison with serology
Validation of the Diabetomics CovAB SARS-CoV-2 antibody test in children: comparison with serology Open
Monitoring antibody prevalence is a valuable tool to evaluate the burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a community, identify risk factors, and assess the impact of clinical and public health interventio…
View article: A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome
A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome Open
Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investig…
View article: Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content
Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content Open
Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation of diverse origin. The long-standing paradigm that foam cells are cholesterol-laden derives from atherosclerosis research. We previously showed that…
View article: High prevalence of autoantibodies in children after COVID-19 infection of differing levels of severity
High prevalence of autoantibodies in children after COVID-19 infection of differing levels of severity Open
View article: Unveiling Caste Disparities in Under-Five Mortality in India Using Bayesian Model Averaging and Time Trend Analysis: A Repeated Population-Based Cross-Sectional Study from 1987 to 2021
Unveiling Caste Disparities in Under-Five Mortality in India Using Bayesian Model Averaging and Time Trend Analysis: A Repeated Population-Based Cross-Sectional Study from 1987 to 2021 Open
View article: Prevalence and predictors of SARS-CoV-2 seropositivity among volunteer firefighters (October 2020 - August 2021)
Prevalence and predictors of SARS-CoV-2 seropositivity among volunteer firefighters (October 2020 - August 2021) Open
BACKGROUND AND AIM: First responders are at increased risk of SARS-CoV-2 infection (COVID-19). In the US, 67% of firefighters serve as volunteers, yet few studies have assessed COVID-19 prevalence and predictors within this occupational gr…
View article: Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report
Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report Open
While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. We report a case of full resolution of severe COVID-19 due to…
View article: Biologic correlates of beneficial convalescent plasma therapy in a COVID-19 patient reveal disease resolution mechanisms
Biologic correlates of beneficial convalescent plasma therapy in a COVID-19 patient reveal disease resolution mechanisms Open
Background While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. Main body We report a case of full resolution of s…
View article: Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2
Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2 Open
Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated by real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of adenoviral vector-based vacci…
View article: Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection
Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection Open
Monitoring the burden and spread of infection with the new coronavirus SARS-CoV-2, whether within small communities or in large geographical settings, is of paramount importance for public health purposes. Serology, which detects the host …
View article: Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells
Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells Open
Much is to be learned about the interface between immune responses to SARS-CoV-2 infection and vaccination. We monitored immune responses specific to SARS-CoV-2 Spike Receptor-Binding-Domain (RBD) in convalescent individuals for eight mont…
View article: Self-reported symptoms, self-reported viral testing result and seroprevalence of SARS CoV-2 among a community sample in Essex County New Jersey: A brief report
Self-reported symptoms, self-reported viral testing result and seroprevalence of SARS CoV-2 among a community sample in Essex County New Jersey: A brief report Open
Background SARS-CoV-2, the virus that causes COVID-19, has rapidly spread globally beginning in late 2019. Early areas impacted by this pandemic in the US include Essex County, New Jersey. Beyond understanding the prevalence of active infe…