Raimo Voutilainen
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View article: Serum and hair steroid profiles and their associations with body composition in adolescence
Serum and hair steroid profiles and their associations with body composition in adolescence Open
Objective Accurate assessment of steroid hormones is essential for understanding sexual development and metabolic health. Blood-based steroid assays are informative but invasive and reflect only short-term fluctuations. We compared serum a…
View article: Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content
Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content Open
Background/objectives Being born small-for-gestational-age (SGA), is associated with an increased risk of cardiometabolic disease in adulthood. We studied the influence of birth size on hepatocellular lipid (HCL) concentrations in prepuber…
View article: Puberty‐Promoting Treatment and Psychosocial Well‐Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial
Puberty‐Promoting Treatment and Psychosocial Well‐Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial Open
Objective In boys, constitutional delay of growth and puberty (CDGP) has been associated with diverse negative psychosocial effects. Albeit alleviating distress is one of the main reasons for inducing pubertal development, the impact of pu…
View article: Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study
Avocado consumption during pregnancy linked to lower child food allergy risk: prospective KuBiCo study Open
Background Maternal exposures during pregnancy play a critical role in offspring’s health outcomes. This study aimed to investigate how maternal avocado consumption during pregnancy relates to offspring allergic health outcomes using the K…
View article: Associations of gestational anxiety and depression with neonatal hair steroid levels
Associations of gestational anxiety and depression with neonatal hair steroid levels Open
Prenatal maternal anxiety, but not depression, may lead to pronounced alterations in some markers of fetal stress systems. Future research should further determine whether prenatal maternal symptoms of anxiety would form an optimal interve…
View article: Remarks on Fixed Point Approaches to Insurance and Finance
Remarks on Fixed Point Approaches to Insurance and Finance Open
Fixed point theory has been applied to various practical problems of insurance and finance during several decades. In our earlier paper (Voutilainen, 2022) we have presented problem classes tackled in the literature by fixed point methods.…
View article: Cognitive performance in young adult women with a history of premature adrenarche
Cognitive performance in young adult women with a history of premature adrenarche Open
View article: Avocado consumption during pregnancy is associated with child's lower food allergy risk in the prospective KuBiCo study
Avocado consumption during pregnancy is associated with child's lower food allergy risk in the prospective KuBiCo study Open
Background Maternal exposures (e.g., nutrition) during pregnancy play a critical role in offspring's health outcomes. Certain nutrients found in avocados have been associated with lower allergic health outcomes in children when consumed du…
View article: Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort
Maternal caffeine intake during pregnancy and the risk of delivering a small for gestational age baby: Kuopio Birth Cohort Open
View article: Health-Related Quality of Life of Young Adult Women with a History of Premature Adrenarche
Health-Related Quality of Life of Young Adult Women with a History of Premature Adrenarche Open
Introduction: Children with premature adrenarche (PA) have increased adrenal androgen concentrations and earlier pubertal development than their peers. Early sexual maturation and exposure to androgens have both been associated with an inc…
View article: Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort
Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort Open
Caffeine intake during the first trimester of pregnancy was not associated with the risk of GDM but a minor non-significant decrease was seen with moderate coffee intake. Although the average consumption of cola drinks was low in the KuBiC…
View article: Accelerated Early Childhood Growth Is Associated With the Development of Earlier Adrenarche and Puberty
Accelerated Early Childhood Growth Is Associated With the Development of Earlier Adrenarche and Puberty Open
Context Small birth size and increased postnatal growth have been associated with earlier timing of adrenarche and puberty, but it is not well known whether these factors alone or together lead to earlier maturation. Objective This work ai…
View article: Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism Open
Previous steroid hormone studies concerning pregnancy and newborns have mainly focused on glucocorticoids; wider steroid profiles have been less commonly investigated. Here, we performed a comparative analysis of 17 steroids from newborn h…
View article: Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study
Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study Open
Context Childhood overweight has been linked to earlier development of adrenarche and puberty, but it remains unknown if lifestyle interventions influence sexual maturation in general populations. Objective To investigate if a 2-year lifes…
View article: Cardiorespiratory Fitness in Young Adult Women With a History of Premature Adrenarche
Cardiorespiratory Fitness in Young Adult Women With a History of Premature Adrenarche Open
Context Premature adrenarche (PA) may predispose to some adverse long-term health outcomes. Cardiorespiratory fitness (CRF) is one of the strongest factors known to predict overall health, but no data exist on the CRF of women with a histo…
View article: Health-related quality of life in boys with constitutional delay of growth and puberty
Health-related quality of life in boys with constitutional delay of growth and puberty Open
Introduction Constitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the …
View article: Adoption of incentive-based insurance applications: the perspective of psychological ownership
Adoption of incentive-based insurance applications: the perspective of psychological ownership Open
Incentive-based health insurance applications have been implemented to trigger lower insurance premiums when the individual follows healthy living habits. It has been recognised that this benefit notwithstanding, consumers’ perceptions rel…
View article: A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair Open
Hair steroid analysis offers the possibility to evaluate long-term steroid metabolism. It is especially beneficial when studying the steroid milieu in newborns and children, for example it can provide new insights into steroid metabolism o…
View article: The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study Open
Introduction We aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 ye…
View article: Circulating Liver-enriched Antimicrobial Peptide-2 Decreases During Male Puberty
Circulating Liver-enriched Antimicrobial Peptide-2 Decreases During Male Puberty Open
Context Circulating levels of liver-enriched antimicrobial peptide 2 (LEAP2), a ghrelin receptor antagonist, decrease under caloric restriction and increase in obesity. The role of LEAP2 in male puberty, a phase with accelerated energy dem…
View article: Optical coherence tomography shows decreased thickness of retinal nerve fibre layer among foetal alcohol exposed young adults in a case–control study
Optical coherence tomography shows decreased thickness of retinal nerve fibre layer among foetal alcohol exposed young adults in a case–control study Open
Foetal alcohol spectrum disorder is an umbrella term that describes all the foetal alcohol effects. We lack a reliable biomarker to detect foetal alcohol exposure and a uniform way to diagnose foetal alcohol spectrum disorder (Cook 2003; C…
View article: PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche Open
Context Premature adrenarche (PA) may increase the risk for polycystic ovary syndrome (PCOS). Objective To study features of PCOS in young adult women with a history of PA. Methods Thirty PA and 42 control females were followed from prepub…
View article: The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study
The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study Open
The infants of mothers with elevated depressive symptoms (EDS) postpartum appear to be at increased risk of somatic health problems during their first 12 months of life in low- and lower-middle-income countries. However, in higher-income c…
View article: The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study
The effect of maternal alcohol and drug abuse on first trimester screening analytes: a retrospective cohort study Open
View article: Caffeine content in newborn hair correlates with maternal dietary intake
Caffeine content in newborn hair correlates with maternal dietary intake Open
Purpose High-maternal caffeine intake during pregnancy may be harmful for perinatal outcomes and future child health, but the level of fetal cumulative exposure has been difficult to measure thus far. Here, we present maternal dietary caff…
Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study Open
View article: Ennenaikainen adrenarke : yleinen, moni-ilmeinen ja hyväennusteinen kehitysvariantti
Ennenaikainen adrenarke : yleinen, moni-ilmeinen ja hyväennusteinen kehitysvariantti Open
View article: Birth Size as a Determinant of Cardiometabolic Risk Factors in Children
Birth Size as a Determinant of Cardiometabolic Risk Factors in Children Open
The association between birth size and cardiometabolic disease risk may be U-shaped. Being born small for gestational age (SGA) has a definitive association with later cardiovascular risk, but the impact of being born large for gestational…
View article: Association of Serum Total Osteocalcin Concentrations With Endogenous Glucocorticoids and Insulin Sensitivity Markers in 12-Year-Old Children: A Cross-Sectional Study
Association of Serum Total Osteocalcin Concentrations With Endogenous Glucocorticoids and Insulin Sensitivity Markers in 12-Year-Old Children: A Cross-Sectional Study Open
Background: Osteocalcin (OC) is an osteoblast-derived marker of bone turnover that has recently been linked to glucose metabolism, glucocorticoid action, and cardiovascular risk. Objective: We determined whether serum total O…
View article: Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone
Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone Open
STUDY QUESTION Does treatment of constitutional delay of growth and puberty (CDGP) in boys with aromatase inhibitor letrozole (Lz) or conventional low-dose testosterone (T) have differing effects on developing seminiferous epithelium? SUMM…