Raimon Sunyer
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View article: Single cell migration along and against confined haptotactic gradients
Single cell migration along and against confined haptotactic gradients Open
Directed cell migration along gradients of extracellular matrix (ECM) density –a process called haptotaxis– plays a central role in morphogenesis, the immune response, and cancer invasion. It is commonly assumed that cells respond to these…
View article: Trusting the forces of our cell lines
Trusting the forces of our cell lines Open
Cells isolated from their native tissues and cultured in vitro face different selection pressures than those cultured in vivo. These pressures induce a profound transformation that reshapes the cell, alters its genome, and transforms the w…
View article: Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature
Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature Open
Exposure of experimental rodents to controlled cycles of light, food, and temperature is important when investigating alterations in circadian cycles that profoundly influence health and disease. However, applying such stimuli simultaneous…
View article: Low-Cost, Open-Source Device for Simultaneously Subjecting Rodents to Different Circadian Cycles of Light, Food, and Temperature
Low-Cost, Open-Source Device for Simultaneously Subjecting Rodents to Different Circadian Cycles of Light, Food, and Temperature Open
Exposure of experimental rodents to controlled cycles of light, food, and temperature is important when investigating alterations in circadian cycles that profoundly influence health and disease. However, applying such stimuli simultaneous…
View article: Characterization of Bioinks Prepared via Gelifying Extracellular Matrix from Decellularized Porcine Myocardia
Characterization of Bioinks Prepared via Gelifying Extracellular Matrix from Decellularized Porcine Myocardia Open
Since the emergence of 3D bioprinting technology, both synthetic and natural materials have been used to develop bioinks for producing cell-laden cardiac grafts. To this end, extracellular-matrix (ECM)-derived hydrogels can be used to deve…
View article: Application of intermittent hypoxia to precisely-cut tissue slices: a novel ex vivo model for studying the parenchymal effects of obstructive sleep apnea (OSA)
Application of intermittent hypoxia to precisely-cut tissue slices: a novel ex vivo model for studying the parenchymal effects of obstructive sleep apnea (OSA) Open
Background: Experimental OSA models currently apply intermittent hypoxia to cells conventionally cultured in 2D plates, but there is no setting to subject cells to well-controlled intermittent hypoxia in a 3D environment and enable the stu…
View article: Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea
Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea Open
Background: Patients with obstructive sleep apnea (OSA) experience recurrent hypoxemic events with a frequency sometimes exceeding 60 events/h. These episodic events induce downstream transient hypoxia in the parenchymal tissue of all orga…
View article: Towards a robust criterion of anomalous diffusion
Towards a robust criterion of anomalous diffusion Open
Anomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the traditional law of Brownian-motion, is a signature feature of a large number of complex soft-matter and biological systems. Anomalous-diffusion em…
View article: The Forces behind Directed Cell Migration
The Forces behind Directed Cell Migration Open
Directed cell migration is an essential building block of life, present when an embryo develops, a dendritic cell migrates toward a lymphatic vessel, or a fibrotic organ fails to restore its normal parenchyma. Directed cell migration is of…
View article: Stiffness-dependent active wetting enables optimal collective cell durotaxis
Stiffness-dependent active wetting enables optimal collective cell durotaxis Open
The directed migration of cellular clusters enables morphogenesis, wound healing, and collective cancer invasion. Gradients of substrate stiffness are known to direct the migration of cellular clusters in a process called collective durota…
View article: Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development Open
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial …
View article: Mapping mechanical stress in curved epithelia of designed size and shape
Mapping mechanical stress in curved epithelia of designed size and shape Open
The function of organs such as lungs, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. To adopt shapes such as spheres, tubes and ellipsoids, epithelia generate mechanical stresses that are generally…
View article: Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development
Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development Open
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial …
View article: Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions
Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions Open
This study reports novel findings that link E-cadherin (also known as CDH1)-mediated force-transduction signaling to vinculin targeting to intercellular junctions via epidermal growth factor receptor (EGFR) and integrins. These results bui…
View article: Collective cell durotaxis emerges from long-range intercellular force transmission
Collective cell durotaxis emerges from long-range intercellular force transmission Open
The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cell…