Raimund Helbok
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View article: Acute Sulcal FLAIR Hyperintensity in Severe Tick-Borne Encephalitis: A Potential Prognostic Marker
Acute Sulcal FLAIR Hyperintensity in Severe Tick-Borne Encephalitis: A Potential Prognostic Marker Open
(1) Background: To report two cases of severe tick-borne encephalitis (TBE) in elderly patients presenting with a previously undescribed subarachnoid T2/FLAIR hyperintensity on repeated MRI examinations, which may serve as an early imaging…
View article: CSF CXCL13 as a longitudinal marker for neurocognition in HIV-1-associated dementia after start of treatment in cART-naïve patients
CSF CXCL13 as a longitudinal marker for neurocognition in HIV-1-associated dementia after start of treatment in cART-naïve patients Open
Objectives Despite suppression of viral replication by antiretroviral therapy (cART) HIV-associated neurocognitive disorders (HAND) may persist. This involves chronic inflammation with activation of the monocyte-macrophage-microglia axis. …
View article: HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability
HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability Open
Post-stroke epilepsy (PSE) is a leading cause of acquired epilepsy in adults, yet the molecular mechanisms linking post-ischemic hypoxia to neuronal hyperexcitability remain poorly understood. The transcription factor hypoxia-inducible fac…
View article: Beyond the bleed: complications after aneurysmal subarachnoid hemorrhage. Pathophysiology, clinical implications, and management strategies: a review
Beyond the bleed: complications after aneurysmal subarachnoid hemorrhage. Pathophysiology, clinical implications, and management strategies: a review Open
Aneurysmal subarachnoid hemorrhage is a critical condition with high case-fatality and lasting impacts on survivors. Acute events that are the direct result of aneurysm rupture, such as acute ischemia, elevated intracranial pressure, cereb…
View article: Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section
Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf of the DIVI neurology section Open
Background Aneurysmal subarachnoid hemorrhage (aSAH) is a critical condition requiring multidisciplinary management, particularly in the intensive care setting. Despite existing guidelines, gaps in evidence and variability in practice rema…
View article: The Impact of Frailty on Functional Outcome in Neurointensive Care Patients
The Impact of Frailty on Functional Outcome in Neurointensive Care Patients Open
Background Frailty, defined as an age‐related syndrome of multidimensional physiological decline, may serve as a valuable marker to identify brain‐injured patients who are less likely to benefit from aggressive treatment, thus avoiding unn…
View article: Correction: Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study
Correction: Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study Open
View article: Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID‐19 task force of the European Academy of Neurology
Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID‐19 task force of the European Academy of Neurology Open
Background Neuropathological and clinical studies suggest that infection with SARS-CoV-2 may increase the long-term risk of neurodegeneration. Methods We provide a narrative overview of pathological and clinical observations justifying the…
View article: Protocol for olfactory training in persisting COVID-19-associated loss of smell (SMELL): a monocentric randomised controlled trial conducted in Innsbruck
Protocol for olfactory training in persisting COVID-19-associated loss of smell (SMELL): a monocentric randomised controlled trial conducted in Innsbruck Open
Introduction Olfactory dysfunction (OD) following COVID-19 affected up to 70% of patients, with more than 30% still reporting lingering symptoms a year later. Treatment is essential, as previous research has linked (postviral) OD to depres…
View article: Voxel‐Based Lesion Symptom Mapping to Predict Poststroke Epilepsy After Mechanical Thrombectomy
Voxel‐Based Lesion Symptom Mapping to Predict Poststroke Epilepsy After Mechanical Thrombectomy Open
Introduction Poststroke epilepsy (PSE) is an important long‐term complication after stroke. Data regarding predictors of PSE in patients with large‐vessel occlusion stroke receiving mechanical thrombectomy (MT) are scarce. Voxel‐based lesi…
View article: Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study
Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study Open
View article: Faster Decay of Cerebrospinal Fluid Red Blood Cells and Total Protein Predict Good Functional Outcome After Subarachnoid Hemorrhage
Faster Decay of Cerebrospinal Fluid Red Blood Cells and Total Protein Predict Good Functional Outcome After Subarachnoid Hemorrhage Open
Introduction Prognostication after subarachnoid hemorrhage (SAH) is essential to guide clinical management and improve patient care. Objective To investigate whether decay rates of cerebrospinal fluid (CSF) red blood cells (RBC) and total …
View article: External validation of the MR PREDICTS@24H model: predicting functional outcome after endovascular treatment in stroke
External validation of the MR PREDICTS@24H model: predicting functional outcome after endovascular treatment in stroke Open
Background Chalos et al recently developed the MR PREDICTS@24H model to predict 90 days functional outcomes in ischaemic stroke patients following endovascular treatment (EVT). We aimed to validate this model in the real-world situation of…
View article: Health-related quality of life after spontaneous subarachnoid hemorrhage – a prospective cohort study
Health-related quality of life after spontaneous subarachnoid hemorrhage – a prospective cohort study Open
Purpose Reduced health-related quality of life (HR-QoL) is common after spontaneous subarachnoid hemorrhage (SAH). Here, we aimed to describe the prevalence of HR-QoL impairment one year after SAH and to identify associated factors. Method…
View article: The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study
The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study Open
This work describes the use of high resolution online microdialysis coupled with a wireless microfluidic electrochemical sensing platform for continuous monitoring of the effect of cardiac arrest and resuscitation methods on brain glucose …
View article: Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury
Impact of age and mean intracranial pressure on the morphology of intracranial pressure waveform and its association with mortality in traumatic brain injury Open
Background Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also by intracranial hypertension and aging. …
View article: Update on traumatic brain injury in the ICU
Update on traumatic brain injury in the ICU Open
Purpose of review This review aims to summarize recent developments for the management of severe traumatic brain injury (TBI) in the ICU. Recent advancements in TBI ICU management emphasize a progression toward more multimodal approaches a…
View article: Is there still hesitancy towards SARS-CoV-2 vaccination among people with neurological disease– a survey of the NeuroCOVID-19 task force of the European Academy of Neurology
Is there still hesitancy towards SARS-CoV-2 vaccination among people with neurological disease– a survey of the NeuroCOVID-19 task force of the European Academy of Neurology Open
View article: TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury
TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury Open
View article: Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus
Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus Open
This consensus establishes foundational COS and reporting guidelines for iMMM in neurocritical care. These harmonization tools can enhance research quality, comparability, and reproducibility, facilitating evidence-based practices for this…
View article: Exploration of simultaneous transients between cerebral hemodynamics and the autonomic nervous system using windowed time-lagged cross-correlation matrices: a CENTER-TBI study
Exploration of simultaneous transients between cerebral hemodynamics and the autonomic nervous system using windowed time-lagged cross-correlation matrices: a CENTER-TBI study Open
View article: Unsupervised Clustering in Neurocritical Care: A Systematic Review
Unsupervised Clustering in Neurocritical Care: A Systematic Review Open
View article: Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage
Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage Open
Background and Purpose Prognostication in patients with spontaneous subarachnoid hemorrhage (SAH) can be challenging. The aim of this study was to assess whether cerebrospinal fluid (CSF) red blood cell (RBC) count and total protein (TP) c…
View article: Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign
Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data Open
View article: Liberalization of the Systemic Glucose Management is Associated with a Reduced Frequency of Neuroglucopenia in Subarachnoid Hemorrhage Patients: An Observational Cohort Study
Liberalization of the Systemic Glucose Management is Associated with a Reduced Frequency of Neuroglucopenia in Subarachnoid Hemorrhage Patients: An Observational Cohort Study Open
Background Pathologically low brain glucose levels, referred to as neuroglucopenia, are associated with unfavorable outcomes in neurocritical care patients. We sought to investigate whether an increase in serum glucose levels would be asso…
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging Open
The list of Curing Coma Campaign Collaborators included in the Acknowledgements section has been updated. Flora Hammond, Raimund Helbok, and Naomi Niznick have been added to the list. Several spelling errors have been corrected. A revised …
View article: Autoimmune and infectious encephalitis: development of a discriminative tool for early diagnosis and initiation of therapy
Autoimmune and infectious encephalitis: development of a discriminative tool for early diagnosis and initiation of therapy Open
Background Encephalitis originates from diverse autoimmune and infectious etiologies. Diagnostic challenges arise due to the spectrum of presentation and the frequent absence of specific biomarkers. This study aimed to comprehensively char…
View article: High Somatization Rates, Frequent Spontaneous Recovery, and a Lack of Organic Biomarkers in Post‐Covid‐19 Condition
High Somatization Rates, Frequent Spontaneous Recovery, and a Lack of Organic Biomarkers in Post‐Covid‐19 Condition Open
Introduction Many patients report neuropsychiatric symptoms after SARS‐CoV‐2 infection. Data on prevalence of post‐COVID‐19 condition (PCC) vary due to the lack of specific diagnostic criteria, the report of unspecific symptoms, and reliab…
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population Open