Rainer Krull
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View article: On a new approach to describing soft pellets of filamentous cultivated in shake flasks under turbulent flow conditions
On a new approach to describing soft pellets of filamentous cultivated in shake flasks under turbulent flow conditions Open
View article: Low-gradient magnetic separation in Biotechnology: Parameter identification and model-guided scale up
Low-gradient magnetic separation in Biotechnology: Parameter identification and model-guided scale up Open
View article: Automation of a Capillary‐Wave Microbioreactor Platform to Enhance Phage Sensitivity Screen Efficiency
Automation of a Capillary‐Wave Microbioreactor Platform to Enhance Phage Sensitivity Screen Efficiency Open
To increase their throughput, reduce laboratory work and improve reproducibility, automation of bioprocesses is gaining in importance nowadays. This applies in particular to microbioreactors (MBRs), which can be easily integrated in highly…
View article: Low-Gradient Magnetic Separation in Biotechnology: Parameter Identification and Model-Guided Scale Up
Low-Gradient Magnetic Separation in Biotechnology: Parameter Identification and Model-Guided Scale Up Open
View article: Rheology and Culture Reproducibility of Filamentous Microorganisms: Impact of Flow Behavior and Oxygen Transfer During Salt‐Enhanced Cultivation of the Actinomycete <i>Actinomadura namibiensis</i>
Rheology and Culture Reproducibility of Filamentous Microorganisms: Impact of Flow Behavior and Oxygen Transfer During Salt‐Enhanced Cultivation of the Actinomycete <i>Actinomadura namibiensis</i> Open
Analyzing the relationship between cell morphology, rheological characteristics, and production dynamics of cultivations with filamentous microorganisms is a challenging task. The complex interdependencies and the commonly low reproducibil…
View article: Oxygen Consumption in Filamentous Pellets of <i>Aspergillus niger</i>: Microelectrode Measurements and Modeling
Oxygen Consumption in Filamentous Pellets of <i>Aspergillus niger</i>: Microelectrode Measurements and Modeling Open
Filamentous fungi cultivated as biopellets are well established in biotechnology industries. A distinctive feature of filamentous fungi is that hyphal growth and fungal morphology affect product titers and require tailored process conditio…
View article: 2PP-Hydrogel Covered Electrodes to Compensate for Media Effects in the Determination of Biomass in a Capillary Wave Micro Bioreactor
2PP-Hydrogel Covered Electrodes to Compensate for Media Effects in the Determination of Biomass in a Capillary Wave Micro Bioreactor Open
Microbioreactors increase information output in biopharmaceutical screening applications because they can be operated in parallel without consuming large quantities of the pharmaceutical formulations being tested. A capillary wave microbio…
View article: PhagoScreener: A novel phagogram platform based on a capillary-wave microbioreactor
PhagoScreener: A novel phagogram platform based on a capillary-wave microbioreactor Open
View article: Morphological and mechanical properties of filamentous pellets during the cultivation process
Morphological and mechanical properties of filamentous pellets during the cultivation process Open
Filamentous bacteria and fungi are attracting increasing attention due to their medicinal value. Among these microorganisms, Actinomadura namibiensis has attracted great interest due to its ability to produce Labyrinthopeptin A1 with antiv…
View article: 3D imaging and analysis to unveil the impact of microparticles on the pellet morphology of filamentous fungi
3D imaging and analysis to unveil the impact of microparticles on the pellet morphology of filamentous fungi Open
Controlling the morphology of filamentous fungi is crucial to improve the performance of fungal bioprocesses. Microparticle‐enhanced cultivation (MPEC) increases productivity, most likely by changing the fungal morphology. However, due to …
View article: 11 Intensification of bioprocesses with filamentous microorganisms
11 Intensification of bioprocesses with filamentous microorganisms Open
Many industrial biotechnological processes use filamentous microorganisms to produce platform chemicals, proteins, enzymes and natural products. Product formation is directly linked to their cellular morphology ranging from dispersed mycel…
View article: Frontmatter
Frontmatter Open
View article: Exploring Functionality Gain for (Recombinant) β-Lactoglobulin Through Production and Processing Interventions
Exploring Functionality Gain for (Recombinant) β-Lactoglobulin Through Production and Processing Interventions Open
Interventions in the upstream production and further processing of recombinant food proteins affect its properties when used for food application. Often the efficiency of particular interventions is evaluated based on molecular purity and …
View article: Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions
Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions Open
In biotechnological processes, filamentous microorganisms are known for their broad product spectrum and complex cellular morphology. Product formation and cellular morphology are often closely linked, requiring a well-defined level of mec…
View article: Precision fermentation as a route to modify β-lactoglobulin structure through substitution of specific cysteine residues
Precision fermentation as a route to modify β-lactoglobulin structure through substitution of specific cysteine residues Open
View article: Amyloid-like aggregation of recombinant β-lactoglobulin at pH 3.5 and 7.0: Is disulfide bond removal the key to fibrillation?
Amyloid-like aggregation of recombinant β-lactoglobulin at pH 3.5 and 7.0: Is disulfide bond removal the key to fibrillation? Open
View article: Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes
Morphology engineering for novel antibiotics: Effect of glass microparticles and soy lecithin on rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes Open
Lentzea aerocolonigenes , as an actinomycete, is a natural producer of the antibiotic and antitumoral drug rebeccamycin. Due to the filamentous cellular morphology handling in cultivations is challenging; therefore, morphology engineering …
View article: Fibrillation of β-lactoglobulin at pH 2.0: Impact of cysteine substitution and disulfide bond reduction
Fibrillation of β-lactoglobulin at pH 2.0: Impact of cysteine substitution and disulfide bond reduction Open
View article: Intensification of bioprocesses with filamentous microorganisms
Intensification of bioprocesses with filamentous microorganisms Open
Many industrial biotechnological processes use filamentous microorganisms to produce platform chemicals, proteins, enzymes and natural products. Product formation is directly linked to their cellular morphology ranging from dispersed mycel…
View article: Precision Fermentation as a Route to Modify Β-Lactoglobulin Structure Through Substitution of Specific Cysteine Residues
Precision Fermentation as a Route to Modify Β-Lactoglobulin Structure Through Substitution of Specific Cysteine Residues Open
View article: Production and Characterization of Bacterial Cellulose Separators for Nickel-Zinc Batteries
Production and Characterization of Bacterial Cellulose Separators for Nickel-Zinc Batteries Open
The need for energy-storing technologies with lower environmental impact than Li-ion batteries but similar power metrics has revived research in Zn-based battery chemistries. The application of bio-based materials as a replacement for curr…
View article: Microsensor in Microbioreactors: Full Bioprocess Characterization in a Novel Capillary-Wave Microbioreactor
Microsensor in Microbioreactors: Full Bioprocess Characterization in a Novel Capillary-Wave Microbioreactor Open
Microbioreactors (MBRs) with a volume below 1 mL are promising alternatives to established cultivation platforms such as shake flasks, lab-scale bioreactors and microtiter plates. Their main advantages are simple automatization and paralle…
View article: Reaction kinetics of anodic biofilms under changing substrate concentrations: Uncovering shifts in Nernst‐Monod curves via substrate pulses
Reaction kinetics of anodic biofilms under changing substrate concentrations: Uncovering shifts in Nernst‐Monod curves via substrate pulses Open
In the present study, it is shown that the concentration dependency of undefined mixed culture anodic biofilms does not follow a single kinetic curve, such as the Nernst‐Monod curve. The biofilms adapt to concentration changes, which inevi…
View article: Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms
Effects and interactions of metal oxides in microparticle‐enhanced cultivation of filamentous microorganisms Open
Filamentous microorganisms are used as molecular factories in industrial biotechnology. In 2007, a new approach to improve productivity in submerged cultivation was introduced: microparticle‐enhanced cultivation (MPEC). Since then, numerou…
View article: Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering
Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering Open
Filamentous fungal cell factories are efficient producers of platform chemicals, proteins, enzymes and natural products. Stirred-tank bioreactors up to a scale of several hundred m³ are commonly used for their cultivation. Fungal hyphae se…
View article: Macroparticle‐enhanced cultivation of <i>Lentzea aerocolonigenes</i>: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production
Macroparticle‐enhanced cultivation of <i>Lentzea aerocolonigenes</i>: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production Open
The actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. In previous studies the rebeccamycin production was significantly increased by the addition of glass beads during cultivation in different diameters b…
View article: Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production
Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production Open
The actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. In previous studies the rebeccamycin production was significantly increased by the addition of glass beads during cultivation in different diameters b…
View article: 3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation
3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation Open
View article: Front Cover: Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems—A critical review
Front Cover: Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems—A critical review Open
DOI: 10.1002/elsc.202000060 The cover page shows a collage of pelleted actinomycetes: Center – Depth‐coded image of Actinomadura namibiensis. Corner points (from top left clockwise) – Mechanical compression experiment on a single pellet (A…
View article: XAD Resins for Increased Rebeccamycin Productivity in Cultivations of <i>Lentzea aerocolonigenes</i>
XAD Resins for Increased Rebeccamycin Productivity in Cultivations of <i>Lentzea aerocolonigenes</i> Open
Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. For a medical application maximized titers and appropriate downstream processing are necessary. The addition of the adsorbents XAD 4, XAD 17 HP, and XAD 16 N was inves…