Rainer Kühn
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View article: Co-Creation Toolkit: A Guidance on the design, development and implementation of effective co-creation in industry-citizen collaboration settings
Co-Creation Toolkit: A Guidance on the design, development and implementation of effective co-creation in industry-citizen collaboration settings Open
This co-creation toolkit provides tools and guidelines for starting and running a responsible innovation process. Based on the experiences from 19 workshops and additional theoretical research, this Toolkit aims to provide an insight into …
View article: Einstellungen in Deutschland zu Wasserstofftechnologien: Ergebnisse von Repräsentativbefragungen in der Übersicht
Einstellungen in Deutschland zu Wasserstofftechnologien: Ergebnisse von Repräsentativbefragungen in der Übersicht Open
Wasserstoff soll eine zentrale Rolle bei der Weiterentwicklung und Vollendung der Energiewende spielen. Doch welche Einstellung haben die Bürger*innen zu dieser Technologie? In einer Metastudie im Rahmen des Reallabors H2-Wyhlen (https://w…
View article: Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition Open
Significance In Huntington disease (HD) gene carriers the disease-causing mutant Huntingtin (m HTT ) is already present during early developmental stages, but, surprisingly, HD patients develop clinical symptoms only many years later. Whil…
View article: Insights into and Recommendations from Three Real-World Laboratories: An Experience-Based Comparison
Insights into and Recommendations from Three Real-World Laboratories: An Experience-Based Comparison Open
Real-world laboratories (RwLs) from an inside perspective: comparing interior design, sustainable development, transformation and learning in three RwLs, we present core issues for the future design of RwLs.Real-world laboratories (RwLs) a…
View article: LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease
LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease Open
Our efficacious results of LBH589 in fragment and full-length mouse models of HD suggest that LBH589 is a promising candidate for clinical assessment in HD patients and provides confirmation that non-selective HDAC inhibitors can be viable…
View article: Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients Open
CHDI Foundation Inc.; Medical Research Council (MRC) UK; National Institutes for Health Research (NIHR); Rosetrees Trust; Swedish Research Council; and Knut and Alice Wallenberg Foundation.