Explanipedia

The Paper-Toss Test: enhancing bedside recognition of corticobasal syndrome Open

Gero Lueg, Thomas Duning, Markus A. Hobert, Alexander Rösler, Sara Peranovic , et al. · 2025

Introduction The diagnosis of corticobasal syndrome (CBS) is challenging due to its clinical overlap with other neurodegenerative disorders. Ideomotor apraxia is a core feature of CBS and often presents asymmetrically, but is often under-r…

Potential causes of malnutrition in older adults in primary healthcare—A cross-sectional study Open

Stefan Pfannkuch, Rainer Wirth, Dorothee Volkert, Maryam Pourhassan · 2025

This study highlights the complex multifactorial nature of malnutrition in older adults attending primary healthcare, confirming the superior role of low intake and poor appetite among other determinants. The DoMAP model offers a structure…

A complex osteoporotic milieu is associated with arterial stiffening and PDGF-BB-mediated calcification of human smooth muscle cells Open

Wera Pustlauk, Toralf Roch, Ioanna Maria Dimitriou, Ashley Navarro, Ulrik Stervbo , et al. · 2025

Accumulating evidence links skeletal and vascular aging, yet the pathological cross-talk between osteoporotic bone and vascular calcification remains insufficiently understood. In this retrospective exploratory study, we show that osteopor…

Hydration Status in Geriatric Patients—Subjective Impression or Objective Parameter? The Hydr-Age-Study Open

Linda Deissler, Matthias Janneck, Rainer Wirth, Alexander Fierenz, Ulrich Thiem , et al. · 2025

Background/Objectives: Assessing the hydration status (HS) in geriatric patients remains challenging due to multimorbidity, polypharmacy, and cognitive impairment. Common indicators like reduced skin turgor and dry mucous membranes are unr…

General disease symptoms and their impact on appetite and food intake in older hospitalized patients Open

Maryam Pourhassan, Diana Daubert, Lars Sieske, Chantal Giehl, Nina Rosa Neuendorff , et al. · 2025

This prospective longitudinal observational study investigated the associations between individual disease symptoms and appetite among 200 older hospitalized patients (mean age 81.4 ± 6.8 years, 62.5 % women) from admission to 7 days later…

40 Jahre Deutsche Gesellschaft für Geriatrie (DGG) – gefragt, gereift, gestärkt Open

Werner Hofmann, Stefan Grund, Rainer Wirth, Jürgen M. Bauer, H. J. Heppner , et al. · 2025

Endoscopic characterization of oropharyngeal dysphagia in patients with dementia Open

Sara Peranovic, Maryam Pourhassan, Bendix Labeit, Paul Muhle, Sonja Suntrup‐Krueger , et al. · 2025

Objective Diagnosing and treating dysphagia in patients with dementia is challenging and few studies have been performed to characterize dysphagia based on Flexible Endoscopic Evaluation of Swallowing (FEES). Therefore, we aimed to charact…

Prognostic value of cough force measured by peak expiratory flow in a 4-year longitudinal cohort study of geriatric patients with oropharyngeal dysphagia Open

Kiril Stoev, Rainer Wirth, Bendix Labeit, Paul Muhle, Sonja Suntrup‐Krueger , et al. · 2025

Introduction and objective Oropharyngeal dysphagia (OD) is a potentially life-threatening disorder of the swallowing process that may significantly impair a patient’s prognosis and quality of life. This study aimed to investigate the assoc…

Implementation of a digital nurse to improve the use of digital health applications (DiGA) for older people with depressive disorders (DiGA4Aged): a randomized proof of concept study Open

Anna Mai, Magdalena Pape, Theresa Sophie Busse, Katharina Kunde, Jennifer Bosompem , et al. · 2025

Cognitive decline limits compensatory resource allocation within the aged swallowing network Open

Sonja Suntrup‐Krueger, Paul Muhle, Janna Slavik, Jonas von Itter, Andreas Wollbrink , et al. · 2025

Impact of inflammatory status on intestinal iron absorption in older hospitalized patients Open

Baigang Wang, Rainer Wirth, Elena Bergmann, Lukas Funk, Chantal Giehl , et al. · 2025

Dehydration and Malnutrition—Similar Yet Different: Data from a Prospective Observational Study in Older Hospitalized Patients Open

Nina Rosa Neuendorff, Rainer Wirth, Kiril Stoev, Maria Schnepper, Isabel Levermann , et al. · 2025

Background/Objectives: Dehydration and malnutrition are common conditions in older adults. Although both are regulated by different pathways, they seem to share common risk factors, such as dysphagia and dementia. Only scarce data on their…

Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma Open

Fabian Ullrich, Paul J. Bröckelmann, Amin T. Turki, Abdullah Khan, Elena-Diana Chiru , et al. · 2024

The treatment landscape for lymphoma and multiple myeloma, which disproportionally affect older adults, has been transformed by the advent of T cell-mediated immunotherapies, including immune checkpoint inhibition, T cell-engaging bispecif…

Exploring accessibility, user experience and engagement of digital media among older patients with depression: a pilot and observational screening study protocol of the DiGA4Aged study Open

Chantal Giehl, Magdalini Chatsatrian, Horst Christian Vollmar, Theresa Sophie Busse, Jennifer Bosompem , et al. · 2024

Introduction The prevalence of mental health problems is increasing worldwide, particularly in the vulnerable group of older people. The limited availability of therapists, long wait periods and increasing shortage of healthcare resources …

Impact of Reactive Balance Training on a Perturbation Treadmill on Physical Performance in Geriatric Patients:Results of a Single-Center, Assessor Blinded Randomized Controlled Trial Open

A. P. Petrović, Rainer Wirth, Christiane Klimek, Gero Lueg, Diana Daubert , et al. · 2024

Background/Objectives: Falls and related injuries are a frequent and serious health problem in older persons. Among the various strategies, different forms of active physical training, in particular, have demonstrated success in reducing f…

[ESPEN guideline on clinical nutrition and hydration in geriatrics]. Open

Dorothee Volkert, Anne Marie Beck, Tommy Cederholm, Alfonso J. Cruz‐Jentoft, Lee Hooper , et al. · 2024

Background. Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats.…

Nutrition for the older adult – Current concepts. Report from an ESPEN symposium Open

Dorothee Volkert, N Delzenne, K Demirkan, S Schneider, O Abbasoglu , et al. · 2024

ESPEN guideline on nutrition and hydration in dementia – Update 2024 Open

Dorothee Volkert, Anne Marie Beck, Gerd Faxén Irving, Thomas Frühwald, Lee Hooper , et al. · 2024

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients Open

Lukas Funk, Ulrike Trampisch, Maryam Pourhassan, Rainer Wirth · 2024

In this study, we could not confirm a significant and clinically relevant association between serum vitamin D levels and inflammation, contrasting with a previous study. However, longitudinal studies need to be performed to draw a final co…

Three-Year Mortality of Older Hospitalized Patients with Osteosarcopenia: Data from the OsteoSys Study Open

Maryam Pourhassan, Bjoern Buehring, Ulrik Stervbo, Sven Rahmann, Felix Mölder , et al. · 2024

Osteosarcopenia, the concurrent presence of sarcopenia and osteopenia/osteoporosis, poses a significant health risk to older adults, yet its impact on clinical outcomes is not fully understood. The aim of this prospective, longitudinal mul…

Curriculum „Trachealkanülenmanagement in der Dysphagietherapie“ Open

Christian Ledl, Ulrike Frank, Rainer Dziewas, B. Arnold, N. Bähre , et al. · 2024

The number of tracheotomized patients with dysphagia and their need for treatment are continuously increasing in clinical and community settings. The revised version of the directive on home care and community-based intensive care of the F…

The Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS) Open

Ben Kirk, Peggy M. Cawthon, Hidenori Arai, José Alberto Ávila‐Funes, Rocco Barazzoni , et al. · 2024

Importance Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists. Objective The Global Leadership Initiative in Sarcopenia (G…

Curriculum „Trachealkanülenmanagement in der Dysphagietherapie“ Open

Christian Ledl, Ulrike Frank, Rainer Dziewas, B. Arnold, N. Bähre , et al. · 2024

Prevalence and determinants of micronutrient deficiencies in malnourished older hospitalized patients Open

Kübra Yilmaz, Rainer Wirth, Diana Daubert, Maryam Pourhassan · 2024

The high prevalence of micronutrient deficiencies in malnourished older hospitalized patients underscore the urgent need for targeted interventions to address micronutrient deficiencies in this population, promoting their health status.

Diagnostic accuracy of the ‘Dysphagia Screening Tool for Geriatric Patients’ (DSTG) compared to Flexible Endoscopic Evaluation of Swallowing (FEES) for assessing dysphagia in hospitalized geriatric patients – a diagnostic study Open

Ulrich Thiem, Martin Jäger, Holger Stege, Rainer Wirth · 2023

Optimized Refeeding vs. Standard Care in Malnourished Older Hospitalized Patients: A Prospective, Non-Randomized Cluster-Controlled Study in Geriatric Acute Care Open

Maryam Pourhassan, Diana Daubert, Thea Laurentius, Rainer Wirth · 2023

Malnutrition is a prevalent geriatric syndrome with adverse health outcomes. This study aimed to assess the effectiveness of an optimized protocol for treatment of malnutrition in older hospitalized patients. We conducted a prospective, no…

Characterization of patients admitted to specialized geriatric acute care hospital units with the German version of the Standardized Evaluation and Intervention for Seniors at Risk (SEISAR) screening-instrument: a cross-sectional study Open

Rainer Wirth, Josée Verdon, Helmut Frohnhofen, M. Djukic, M. Meisel , et al. · 2023

Background The S tandardized E valuation and I ntervention for S eniors a t R isk (SEISAR) screening tool records major geriatric problems, originally applied in the emergency department. Particularly, the distinction of compensated and un…

Hydration status assessment in older patients Open

Linda Deißler, Rainer Wirth, Birgit Frilling, Matthias Janneck, Alexander Rösler · 2023

Only five of the 107 methods considered appear to be suitable for determining that a patient is dehydrated. Thus, the available scientific evidence indicates that all clinicians should critically reconsider their own techniques for assessi…

Refeeding Syndrome in Older Hospitalized Patients: Incidence, Management, and Outcomes Open

Kevin Terlisten, Rainer Wirth, Diana Daubert, Maryam Pourhassan · 2023

Refeeding syndrome (RFS) is a serious metabolic disturbance that manifests after reintroducing nutrition to severely malnourished individuals. Especially susceptible are older patients, due to higher malnutrition rates, although the incide…

Severity of Inflammation Is Associated with Food Intake in Hospitalized Geriatric Patients—A Merged Data Analysis Open

Maryam Pourhassan, Tommy Cederholm, Lorenzo M. Donini, Eleonora Poggiogalle, Ursula Schwab , et al. · 2023

The extent to which inflammation impacts food intake remains unclear, serving as a key risk factor for malnutrition as defined by the Global Leadership Initiative on Malnutrition (GLIM). To address this, we analyzed a large, merged dataset…

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