Explanipedia

α-Bromoacetate as a Mild and Safe Brominating Agent in the Light-Driven Vicinal Dibromination of Unactivated Alkenes and Alkynes Open

Harshvardhan Singh, Supuni I. N. Hewa Inaththappulige, Raj Kumar Tak, Ramesh Giri · 2024

Light-induced vicinal dibromination of unactivated alkenes and alkynes has been demonstrated by using methyl α-bromoacetate as a mild brominating agent. A near-visible light (370 nm) light-emitting diode (LED) mediates this simple dibromin…

α-Bromoacetate as a Mild and Safe Brominating Agent in the Light-Driven Vicinal Dibromination of Unactivated Alkene and Alkynes Open

Harshvardhan Singh, Supuni I. N. Hewa Inaththappulige, Raj Kumar Tak, Ramesh Giri · 2024

Light-induced vicinal dibromination of unactivated alkenes and alkyne has been demonstrated by using methyl alpha-bromoacetate as a mild brominating agent. Near-visible light (370 nm) light-emitting diode (LED) mediates this simple dibromi…

Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution Open

Shubham Agrawal, Pankaj Kumar Majhi, Alister S. Goodfellow, Raj Kumar Tak, David B. Cordes , et al. · 2024

A general and highly enantioselective method for the preparation of tetra‐substituted 3‐hydroxyphthalide esters via isothiourea‐catalysed acylative dynamic kinetic resolution (DKR) is reported. Using (2 S ,3 R )‐HyperBTM (5 mol %) as the c…

Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution Open

Shubham Agrawal, Pankaj Kumar Majhi, Alister S. Goodfellow, Raj Kumar Tak, David B. Cordes , et al. · 2024

A general and highly enantioselective method for the preparation of tetra‐substituted 3‐hydroxyphthalide esters via isothiourea‐catalysed acylative dynamic kinetic resolution (DKR) is reported. Using (2 S ,3 R )‐HyperBTM (5 mol %) as the c…

Catalytic Photoredox Carbobromination of Unactivated Alkenes with α-Bromocarbonyls via the Mechanistically Distinct Radical-Addition Radical-Pairing Pathway Open

Harshvardhan Singh, Raj Kumar Tak, Dhruba P. Poudel, Ramesh Giri · 2024

We disclose a catalytic photoredox carbobromination of unactivated alkenes with α-bromocarbonyl compounds under a blue LED light. The reaction proceeds with α-bromoesters, α-bromonitriles and α-bromo-γ-lactones along with terminal and 1,2-…

Enantioselective Synthesis of Tetra-substituted 3-Hydroxyphthalide Esters by Isothiourea-Catalysed Acylative Dynamic Kinetic Resolution Open

Shubham Agrawal, Pankaj Kumar Majhi, Alister S. Goodfellow, Raj Kumar Tak, David B. Cordes , et al. · 2024

A general and highly enantioselective method for the preparation of tetra-substituted 3-hydroxyphthalide esters via isothiourea-catalysed acylative dynamic kinetic resolution (DKR) is reported. Using (2S,3R)-HyperBTM (5 mol%) as the cataly…

Catalytic Photoredox Carbobromination of Unactivated Alkenes with a-Bromocarbonyls via Mechanistically Distinct Radical-Addition Radical-Pairing Pathway Open

Harshvardhan Singh, Raj Kumar Tak, Dhruba P. Poudel, Ramesh Giri · 2023

We disclose a catalytic photoredox carbobromination of unactivated alkenes with -bromocarbonyl compounds under a blue LED light. The reaction proceeds with -bromoesters, -bromonitriles and -bromo--lactones along with terminal and 1,2-disub…

Catalytic Photoredox Carbobromination of Unactivated Alkenes with a-Bromocarbonyls via Mechanistically Distinct Radical-Addition Radical-Pairing Pathway Open

Harshvardhan Singh, Raj Kumar Tak, Dhruba P. Poudel, Ramesh Giri · 2023

We disclose a catalytic photoredox carbobromination of unactivated alkenes with -bromocarbonyl compounds under a 390 nm LED light. The reaction proceeds with -bromoesters, -bromonitriles and -bromo--lactones along with terminal and 1,2-dis…

CCDC 2224825: Experimental Crystal Structure Determination Open

Dhruba P. Poudel, Amrit Pokhrel, Raj Kumar Tak, Majji Shankar, Ramesh Giri · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2224828: Experimental Crystal Structure Determination Open

Dhruba P. Poudel, Amrit Pokhrel, Raj Kumar Tak, Majji Shankar, Ramesh Giri · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2224826: Experimental Crystal Structure Determination Open

Dhruba P. Poudel, Amrit Pokhrel, Raj Kumar Tak, Majji Shankar, Ramesh Giri · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Photosensitized O <sub>2</sub> enables intermolecular alkene cyclopropanation by active methylene compounds Open

Dhruba P. Poudel, Amrit Pokhrel, Raj Kumar Tak, Majji Shankar, Ramesh Giri · 2023

Cyclopropanes are key features in many preclinical, clinical, and commercial drugs, as well as natural products. The most prolific technique for their synthesis is the metal-catalyzed reaction of an alkene with a diazoalkane, a highly ener…

Photosensitized Dioxygen Enables Intermolecular Cyclopropanation of Alkenes Directly with Active Methylene Compounds Open

Dhruba P. Poudel, Amrit Pokhrel, Raj Kumar Tak, Shankar Majji, Ramesh Giri · 2023

Cyclopropane, a versatile synthetic intermediate, is forged as a key structural feature in many preclinical, clinical and commercial drugs, and occur as a skeletal motif in numerous natural products. The most prolific technique for its syn…

CCDC 2145423: Experimental Crystal Structure Determination Open

Rishi R. Sapkota, Raj Kumar Tak, Vivek Aryal, Doleshwar Niroula, Nicholas C. Secosky , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2145421: Experimental Crystal Structure Determination Open

Rishi R. Sapkota, Raj Kumar Tak, Vivek Aryal, Doleshwar Niroula, Nicholas C. Secosky , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Cu-Catalyzed Cyclization/Coupling of Alkenyl Aldimines. Indolization of Aldehydes, Anilines and Arylzinc Reagents Open

Rishi R. Sapkota, Raj Kumar Tak, Vivek Aryal, Doleshwar Niroula, Nicholas C. Secosky , et al. · 2022

We report a Cu(II)-catalyzed cyclization/coupling of alkenyl aldimines with arylzinc reagents to create complex indole-3-diarylmethane derivatives. The aldimines are readily available by simple dehydration, making the process a formal thre…

CCDC 2049408: Experimental Crystal Structure Determination Open

Raj Kumar Tak, Fuyuki Amemiya, Hidetoshi Noda, Masakatsu Shibasaki · 2021

CCDC 1961235: Experimental Crystal Structure Determination Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

CCDC 1961236: Experimental Crystal Structure Determination Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

CCDC 1961238: Experimental Crystal Structure Determination Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

CCDC 1961234: Experimental Crystal Structure Determination Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

CCDC 1961237: Experimental Crystal Structure Determination Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

Ring-opening hydrolysis of spiro-epoxyoxindoles using a reusable sulfonic acid functionalized nitrogen rich carbon catalyst Open

Parth Patel, Raj Kumar Tak, Bhavesh Parmar, Shilpa Dabas, Brijesh Patel , et al. · 2021

Catalytic synthesis of vicinal diols via ring-opening hydrolysis of spiro-epoxyoxindoles.

Generation and application of Cu-bound alkyl nitrenes for the catalyst-controlled synthesis of cyclic β-amino acids Open

Raj Kumar Tak, Fuyuki Amemiya, Hidetoshi Noda, Masakatsu Shibasaki · 2021

Copper-catalysed conditions have been developed for the chemoselective synthesis of cyclic β-amino acids.

CCDC 1889960: Experimental Crystal Structure Determination Open