Rajakumar Anbazhagan
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View article: Effect of Hemineglect on the Quality of Life of Stroke Patients - A Cross-sectional Study
Effect of Hemineglect on the Quality of Life of Stroke Patients - A Cross-sectional Study Open
Introduction: Spatial neglect is an important disabling disorder post-stroke and occurs more frequently after lesions in the right hemisphere, particularly in the parietal lobe. Spatial neglect prolongs stroke survivors’ recovery to indepe…
View article: A Qualitative analysis of parturients’ experience of spinal anesthesia and postoperative complaints
A Qualitative analysis of parturients’ experience of spinal anesthesia and postoperative complaints Open
Background: Cesarean deliveries have increased globally, with regional anesthesia being the preferred technique. Despite the advantages of the procedure, parturients experience apprehension regarding pain, mobility, and complications. The …
View article: Upper arm deep vein thrombosis in a patient with active lupus
Upper arm deep vein thrombosis in a patient with active lupus Open
Upper extremity deep vein thrombosis (UEDVT) is relatively rare, and much less as an initial presentation of systemic lupus erythematosus (SLE). Primary UEDVT should be considered in individuals with unilateral arm swelling where the brach…
View article: Assessment of Fall Risk in the Elderly and Appropriate Preventive Rehabilitation: A Prospective Pre–Post Study
Assessment of Fall Risk in the Elderly and Appropriate Preventive Rehabilitation: A Prospective Pre–Post Study Open
Aim: The aim of this study was to determine the fall risk amongst the elderly and to assess the effect of preventive rehabilitation. Study Design: This was a prospective pre–post study. Materials and Methods: Sixty patients attending the o…
View article: Social Issues Faced by Spinal Cord Injury Patient with Bladder and Bowel Dysfunction – A Cross-Sectional Study
Social Issues Faced by Spinal Cord Injury Patient with Bladder and Bowel Dysfunction – A Cross-Sectional Study Open
Background: The disruption of autonomic function following a spinal cord injury (SCI) is common and can negatively affect quality of life. As social engagement and relationships are critical for well-being and quality of life, it is import…
View article: Factors Determining Risk of Contralateral Lower Limb Amputations in Unilateral Dysvascular Transfemoral and Transtibial Amputees
Factors Determining Risk of Contralateral Lower Limb Amputations in Unilateral Dysvascular Transfemoral and Transtibial Amputees Open
Background: This study deals with the factors influencing contralateral lower limb amputations among unilateral dysvascular transfemoral and transtibial amputees. Aim: (1) Early identification of risk factors responsible for amputations in…
View article: Editorial: Molecular crosstalk between endocrine factors, paracrine signals, and the immune system during aging
Editorial: Molecular crosstalk between endocrine factors, paracrine signals, and the immune system during aging Open
EDITORIAL article Front. Endocrinol., 21 April 2023Sec. Endocrinology of Aging Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1203755
View article: miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA–miRNA Network Analysis
miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA–miRNA Network Analysis Open
GRTH/DDX25 is a testis-specific DEAD-box family of RNA helicase, which plays an essential role in spermatogenesis and male fertility. There are two forms of GRTH, a 56 kDa non-phosphorylated form and a 61 kDa phosphorylated form (pGRTH). G…
View article: Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis
Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis Open
Gonadotropin-regulated testicular RNA helicase (GRTH)/DDX25 is a member of DEAD-box family of RNA helicase essential for the completion of spermatogenesis and male fertility, as evident from GRTH-knockout (KO) mice. In germ cells of male m…
View article: LBMON272 Chromatoid Bodies In The Regulation Of Spermatogenesis: Novel Role Of Grth
LBMON272 Chromatoid Bodies In The Regulation Of Spermatogenesis: Novel Role Of Grth Open
More than 5 million couples in US are affected by infertility. Male infertility is a major cause (>30%), and understanding spermatogenesis is important to address the problem. During early spermatogenesis, mRNAs are actively transcribed…
View article: Chromatoid Bodies in the Regulation of Spermatogenesis: Novel Role of GRTH
Chromatoid Bodies in the Regulation of Spermatogenesis: Novel Role of GRTH Open
Post-transcriptional and translational control of specialized genes play a critical role in the progression of spermatogenesis. During the early stages, mRNAs are actively transcribed and stored, temporarily bound to RNA binding proteins i…
View article: Blockade of GRTH/DDX25 Phosphorylation by Cyclic Peptides Provides an Avenue for Developing a Nonhormonal Male Contraceptive
Blockade of GRTH/DDX25 Phosphorylation by Cyclic Peptides Provides an Avenue for Developing a Nonhormonal Male Contraceptive Open
Gonadotropin-regulated testicular RNA helicase (GRTH)/DDX25 is a DEAD-box RNA helicase essential for the completion of spermatogenesis. Our previous studies indicated that blocking the GRTH phospho-site or perturbing the GRTH/protein kinas…
View article: Crosstalk between PRLR and EGFR/HER2 Signaling Pathways in Breast Cancer
Crosstalk between PRLR and EGFR/HER2 Signaling Pathways in Breast Cancer Open
Prolactin receptor (PRLR) and epidermal growth factor receptor (EGFR/ERBB) signaling pathways activated by prolactin (PRL) and epidermal growth factor (EGF), have a major role in the mammary gland development and in the etiology of breast …
View article: Editorial: Systemic Regulation of Organ Homeostasis and Implications of Hormones and Immunity
Editorial: Systemic Regulation of Organ Homeostasis and Implications of Hormones and Immunity Open
EDITORIAL article Front. Endocrinol., 14 September 2021 | https://doi.org/10.3389/fendo.2021.740835
View article: Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis
Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis Open
GRTH/DDX25 is a member of the DEAD-box family of RNA helicases that play an essential role in spermatogenesis. GRTH knock-in (KI) mice with the human mutant GRTH gene (R242H) show loss of the phospho-species from cytoplasm with preservatio…
View article: An optimized step‐by‐step protocol for isolation of nucleus pulposus, annulus fibrosus, and end plate cells from the mouse intervertebral discs and subsequent preparation of high‐quality intact total <scp>RNA</scp>
An optimized step‐by‐step protocol for isolation of nucleus pulposus, annulus fibrosus, and end plate cells from the mouse intervertebral discs and subsequent preparation of high‐quality intact total <span>RNA</span> Open
Intervertebral disc degeneration is the most significant, and least understood, cause of chronic back pain, affecting almost one in seven individuals at some point of time. Each intervertebral disc has three components; central nucleus pul…
View article: Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis
Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis Open
GRTH/DDX25 is a testicular RNA helicase expressed in germ cells that plays a crucial role in completion of spermatogenesis. Previously, we demonstrated a missense mutation (R242H) of GRTH gene in Japanese infertile patients (5.8…
View article: SAT-031 Linking Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination Network and Acetylation During Spermiogenesis
SAT-031 Linking Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination Network and Acetylation During Spermiogenesis Open
Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), a testis specific RNA helicase essential for the completion of spermatogenesis. Our early studies discovered a missense mutation (R242H) of GRTH gene in 5.8 % of a Japanese populatio…
View article: OR02-03 Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific MRNAs in Chromatoid Bodies During Spermiogenesis
OR02-03 Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific MRNAs in Chromatoid Bodies During Spermiogenesis Open
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX 25) is a member of the DEAD-box family of RNA helicases which play an essential role in spermatogenesis. There are two species of GRTH, the 56 kDa non-phospho and 61 kDa phospho form…
View article: Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive
Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive Open
View article: Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis
Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis Open
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA helicases expressed in meiotic and haploid germ cells which plays an essential role in spermatogenesis. There are two spe…
View article: SUN-215 Phosphorylation Site of Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) and GRTH/PKA Binding Interface: Biochemical and Structural Studies
SUN-215 Phosphorylation Site of Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) and GRTH/PKA Binding Interface: Biochemical and Structural Studies Open
Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), expressed in the male gonad, is essential for the completion of spermatogenesis. Our early studies revealed a missense mutation (R242H) of GRTH in 5.8 % of a patient population with …
View article: A prospective interventional study of postoperative pain, healing rates and incontinence rates following ligation of intersphincter fistula tract procedure
A prospective interventional study of postoperative pain, healing rates and incontinence rates following ligation of intersphincter fistula tract procedure Open
Background: Fistula in ano is one of the oldest ailments known to us, troublesome both to the patient and also challenging to the treating surgeon. The treatment of fistula in ano has evolved so much, to reduce complications and to improve…
View article: A study of effect of tarsal tunnel decompression on sensory improvement in diabetic foot: a prospective randomized control trial
A study of effect of tarsal tunnel decompression on sensory improvement in diabetic foot: a prospective randomized control trial Open
Background: In India approximately, 45000 legs are amputated every year and almost 75% of these amputations are carried out in neuropathic feet which are potentially preventable. Diabetic peripheral nerves are at risk of entrapment neuropa…
View article: Tarsal tunnel decompression: an effective method for prevention of foot complications in diabetic patients with compressive neuropathy at tarsal tunnel
Tarsal tunnel decompression: an effective method for prevention of foot complications in diabetic patients with compressive neuropathy at tarsal tunnel Open
Background: Diabetic foot is one of the most devastating complications of diabetes with 15% lifetime risk of developing ulcer foot. About 80% of diabetic foot is neuropathic in origin, revealing the importance of sensory sensation in preve…
View article: Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene
Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene Open
View article: Contents Vol. 8, 2014
Contents Vol. 8, 2014 Open