Rajamiyer Venkateswaran
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View article: A randomised pilot study evaluating music therapy and virtual reality mindfulness sessions for reducing anxiety and stress in patients undergoing first-time elective cardiac surgery
A randomised pilot study evaluating music therapy and virtual reality mindfulness sessions for reducing anxiety and stress in patients undergoing first-time elective cardiac surgery Open
Cardiac surgery patients may experience stress and anxiety, negatively impacting recovery. Pharmacological treatments are frequently used but may result in side effects. We aimed to assess the effectiveness of immersive virtual reality min…
View article: Author response: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Author response: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
View article: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: Author response: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Author response: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
View article: Reviewer #2 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Reviewer #2 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: Reviewer #1 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Reviewer #1 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: Reviewer #3 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Reviewer #3 (Public Review): Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis
SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis Open
Pulmonary fibrosis is an increasing and major cause of death worldwide. Understanding the cellular and molecular mechanisms underlying the pathophysiology of lung fibrosis may lead to urgently needed diagnostic and prognostic strategies fo…
View article: Clinical–radiological–pathological correlation in pulmonary arterial hypertension
Clinical–radiological–pathological correlation in pulmonary arterial hypertension Open
Pulmonary hypertension (PH) is defined by the presence of a mean pulmonary arterial pressure >20 mmHg. Current guidelines describe five groups of PH with shared pathophysiological and clinical features. In this paper, the first of a series…
View article: Traversing the Learning Curve Associated with a New Minimal Access Aortic Valve Replacement Service
Traversing the Learning Curve Associated with a New Minimal Access Aortic Valve Replacement Service Open
Objective: Isolated aortic valve replacement is a safe and frequently performed cardiac surgical procedure. Although minimal access approaches including right anterior thoracotomy and partial sternotomy have been adopted by some surgeons i…
View article: Additional file 4 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 4 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 4. Significantly changed proteins in heatmap.
View article: Additional file 8 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 8 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 8. Differentially expression mucus proteins in UIP versus Mucinous Adenocarcinoma.
View article: Additional file 5 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 5 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 5. A list of proteins detected in UIP and Mucinous Adenocarcinoma mucus.
View article: Additional file 6 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 6 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 6. A list of mucus protein intensity levels.
View article: Additional file 2 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 2 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 2. A list of detected airway proteins.
View article: Additional file 3 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 3 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 3. Differentially expressed airway proteins.
View article: Additional file 7 of Morphologically intact airways in lung fibrosis have an abnormal proteome
Additional file 7 of Morphologically intact airways in lung fibrosis have an abnormal proteome Open
Additional file 7. A list of mucus secretome associated proteins.
View article: The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia
The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia Open
Honeycombing (HC) is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). HC refers to cystic airways (HC airways) located at sites of dense fibrosis with marked mucus accumulation. Utilizing laser capture microdissec…
View article: Axillary intra-aortic balloon pump, biventricular assist device implantation and subsequent orthotopic heart transplantation in a patient with sickle cell trait
Axillary intra-aortic balloon pump, biventricular assist device implantation and subsequent orthotopic heart transplantation in a patient with sickle cell trait Open
A 38-year-old male with sickle cell trait and acute refractory heart failure received an axillary intra-aortic balloon pump and short-term biventricular assist device. He underwent orthotopic heart transplantation 45 days later, which was …
View article: Circadian Clock Regulated Endocytic Recycling Drives Fibrous Tissue Homeostasis
Circadian Clock Regulated Endocytic Recycling Drives Fibrous Tissue Homeostasis Open
View article: The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix Open
Background The Fibroblastic Focus (FF) is the signature lesion of Idiopathic Pulmonary Fibrosis (IPF) where myofibroblasts accumulate and extracellular matrix (ECM) is produced. However, the molecular composition and function of the FF and…
View article: Surgical aortic valve replacement in the era of transcatheter aortic valve implantation: a review of the UK national database
Surgical aortic valve replacement in the era of transcatheter aortic valve implantation: a review of the UK national database Open
Objectives To date the reported outcomes of surgical aortic valve replacement (SAVR) are mainly in the settings of trials comparing it with evolving transcatheter aortic valve implantation. We set out to examine characteristics and outcome…
View article: Low Incidence of Structural Valve Degeneration With the Trifecta Aortic Valve Bioprosthesis.
Low Incidence of Structural Valve Degeneration With the Trifecta Aortic Valve Bioprosthesis. Open
Objectives: An ideal bioprosthetic heart valve would have excellent haemodynamic performance and a low rate of Structural Valve Degeneration (SVD). The objective of this study was to investigate the haemodynamic performance and incidence o…
View article: Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Open
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-…
View article: Traversing the Learning Curve Associated with a New Minimal Access Aortic Valve Replacement Service
Traversing the Learning Curve Associated with a New Minimal Access Aortic Valve Replacement Service Open
Although our results have demonstrated a significant learning curve effect associated with the introduction of this minimally invasive approach to aortic valve replacement, as demonstrated by the significant reduction in cardiopulmonary by…
View article: Prolongation of time from brain death to retrieval is beneficial to the donor heart
Prolongation of time from brain death to retrieval is beneficial to the donor heart Open
View article: Financial implications of using extracorporeal membrane oxygenation following heart transplantation
Financial implications of using extracorporeal membrane oxygenation following heart transplantation Open
OBJECTIVES Primary graft dysfunction after heart transplant is associated with high morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) can be used to wean patients from cardiopulmonary bypass. This study retrospectively re…
View article: The challenges of venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock
The challenges of venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock Open
View article: Outcome of CentriMag™ extracorporeal mechanical circulatory support use in critical cardiogenic shock (INTERMACS 1) patients
Outcome of CentriMag™ extracorporeal mechanical circulatory support use in critical cardiogenic shock (INTERMACS 1) patients Open
Purpose Prognosis of patients presenting with INTERMACS 1 critical cardiogenic shock is generally poor. The aim of our study was to investigate the results of CentriMag™ extracorporeal short-term mechanical circulatory support as a bridge …