Rajeev Taliyan
YOU?
Author Swipe
View article: The role of diet and nutraceuticals in the amelioration of multidrug resistance amongst cancer patients
The role of diet and nutraceuticals in the amelioration of multidrug resistance amongst cancer patients Open
Background Cancer is one of the leading causes of death globally, with the reported numbers rising every year. Although the medical fraternity has made considerable progress in early detection and treatment interventions, the numbers are e…
View article: Sertraline enhances bacterial control by improving the pharmacodynamic -pharmacokinetic properties of frontline TB drugs
Sertraline enhances bacterial control by improving the pharmacodynamic -pharmacokinetic properties of frontline TB drugs Open
View article: Sertraline enhances bacterial control by improving the pharmacodynamic - pharmacokinetic properties of frontline TB drugs
Sertraline enhances bacterial control by improving the pharmacodynamic - pharmacokinetic properties of frontline TB drugs Open
Given the need for innovative interventions for tackling the burden of TB, host directed therapies have emerged as a promising alternative in recent times. The combination of sertraline with frontline TB drugs has shown excellent promise i…
View article: Significance of blocking layer in GaN HEMT biosensor for S100B detection using serum and saliva
Significance of blocking layer in GaN HEMT biosensor for S100B detection using serum and saliva Open
View article: Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications Open
View article: Enhancing 3-acetyl-11-keto-β-boswellic acid skin permeation <i>via</i> nanostructured lipid carriers: integrating quality by design principles for risk estimation and optimization
Enhancing 3-acetyl-11-keto-β-boswellic acid skin permeation <i>via</i> nanostructured lipid carriers: integrating quality by design principles for risk estimation and optimization Open
AKBA-loaded nanostructured lipid carriers significantly enhanced skin permeation (1.34-fold vs. plain gel), sustained release up to 56 h, offering a stable, promising, scalable strategy for treating inflammatory skin disorders.
View article: Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders
Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders Open
Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the TGR5 receptor in th…
View article: Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma
Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma Open
Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide, and its pathophysiology is characterized by oxidative stress and inflammation. Despite extensive research, effective treatments for TBI remain elusiv…
View article: First Demonstration of GaN HEMT-Based Handheld System for Noninvasive Detection of Traumatic Brain Injury Using Saliva
First Demonstration of GaN HEMT-Based Handheld System for Noninvasive Detection of Traumatic Brain Injury Using Saliva Open
Traumatic brain injury (TBI) is an insult to the brain caused by an external mechanical force that is neither congenital nor degenerative leading to morbidity and mortality among people of various age groups globally.The work reports desig…
View article: Mechanistic Insights of Meglitinides Drug Repurposing and Delivery to Brain for Metabolic Syndrome Linked Neurodegenerative Disease
Mechanistic Insights of Meglitinides Drug Repurposing and Delivery to Brain for Metabolic Syndrome Linked Neurodegenerative Disease Open
Background Metabolic syndrome (MS) includes clusters of metabolic disorders and type 2 DM (T2DM) is most common MS which cause insulin resistance (IR). The IR mediated dysregulation of signaling cascades in brain increase the production an…
View article: BIOLOGICAL EVALUATION OF DEVELOPED REPAGLINIDE LOADED POLYMERIC NANOCARRIERS TO TREAT METABOLIC SYNDROME COMORBID WITH NEURODEGENERATIVE DISORDER
BIOLOGICAL EVALUATION OF DEVELOPED REPAGLINIDE LOADED POLYMERIC NANOCARRIERS TO TREAT METABOLIC SYNDROME COMORBID WITH NEURODEGENERATIVE DISORDER Open
View article: Pre‐Clinical Investigation of Repaglinide Nanoparticles in High Fat Diet with streptozotocin induced memory impaired rats
Pre‐Clinical Investigation of Repaglinide Nanoparticles in High Fat Diet with streptozotocin induced memory impaired rats Open
Background Diabetes Mellitus is a metabolic disorder characterized by insulin resistance with several metabolic abnormalities which trigger neuronal complications, neurodegeneration, and cognitive impairments. Repaglinide (REP) is an insul…
View article: Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer
Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is a life-threatening form of breast cancer which has been found to account for 15% of all the subtypes of breast cancer. Currently available treatments are significantly less effective in TNBC manageme…
View article: Development Of Surface Charge Modified-Biotin Decorated Olaparib Loaded Lipid-Polymeric Hybrid Nanoparticle and Evaluation of its In-Vitro Anticancer Effect and Pharmacokinetics for Triple Negative Breast Cancer Management
Development Of Surface Charge Modified-Biotin Decorated Olaparib Loaded Lipid-Polymeric Hybrid Nanoparticle and Evaluation of its In-Vitro Anticancer Effect and Pharmacokinetics for Triple Negative Breast Cancer Management Open
View article: Advances in Antibody-Based Therapeutics for Cerebral Ischemia
Advances in Antibody-Based Therapeutics for Cerebral Ischemia Open
Cerebral ischemia is an acute disorder characterized by an abrupt reduction in blood flow that results in immediate deprivation of both glucose and oxygen. The main types of cerebral ischemia are ischemic and hemorrhagic stroke. When a str…
View article: Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin
Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin Open
The present work aimed to investigate the induction of circadian rhythm dysfunction and dementia upon chronic exposure to light-light and its reversal by melatonin in Wistar rats. Animals underwent different light-dark conditions, viz., li…
View article: Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling
Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling Open
View article: Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations
Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations Open
View article: Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB Open
The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of homeostasis in the brain. In this way, it is an interesting target as an interface for various types of drug delivery, specifically in the context of the…
View article: Epigenetic Regulation of Mammalian Target of Rapamycin Debilitates Insulin Resistance Associated Alzheimer Disease Condition in Rats
Epigenetic Regulation of Mammalian Target of Rapamycin Debilitates Insulin Resistance Associated Alzheimer Disease Condition in Rats Open
Insulin resistance (IR) and accumulation of amyloid beta (Aβ) oligomers are potential causative factor for Alzheimer Disease (AD). Simultaneously, enhanced clearance level of these oligomers through autophagy activation bring novel insight…
View article: Review for "Analysis of the neuroprotective effect of GLP-1 receptor agonist peptide on cerebral ischemia-reperfusion injury by Quantitative Proteomics Mass Spectrometry"
Review for "Analysis of the neuroprotective effect of GLP-1 receptor agonist peptide on cerebral ischemia-reperfusion injury by Quantitative Proteomics Mass Spectrometry" Open
View article: Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease
Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease Open
View article: Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry
Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry Open
A reliable and sensitive UPLC-MS/MS based method has been developed for the estimation of 4-hydroxyisoleucine, a potent insulinotropic and hypolipidemic agent.
View article: Epigenetic mechanisms in Alzheimer's Disease: Therapeutic potential of Class specific HDAC inhibitors in insulin resistance induced cognitive impairments
Epigenetic mechanisms in Alzheimer's Disease: Therapeutic potential of Class specific HDAC inhibitors in insulin resistance induced cognitive impairments Open
Background: Numerous epidemiological studies have demonstrated that insulin resistance contributes to Alzheimer's disease (AD) pathogenesis. However the molecular mechanisms is still remain elusive but various studies have highlighted the …
View article: GSK-3ß inhibitor, AR-A014418 attenuates insulin resistance induced cognitive deficit in mice
GSK-3ß inhibitor, AR-A014418 attenuates insulin resistance induced cognitive deficit in mice Open
Event Abstract Back to Event GSK-3ß inhibitor, AR-A014418 attenuates insulin resistance induced cognitive deficit in mice Sorabh Sharma1* and Rajeev Taliyan1 1 Birla Institute of Technology and Science, Pilani, Department of Pharmacy, Indi…
View article: Effect of pioglitazone on the abrogated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart
Effect of pioglitazone on the abrogated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart Open
Cardioprotective effect of IPC gets lost in hyperlipidemic rat heart. The results suggest that perfusion of pioglitazone restored the cardioprotective effect of IPC in hyperlipidemic rat heart, an effect that may be via PI3K and mTOR.
View article: Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP
Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP Open
Background: Hydroxy safflor yellow A (HSYA) has been translated clinically for cardiovascular diseases. HSYA is also greatly acknowledged for its protective effects against cerebral ischemic-reperfusion (I/R) injury. Although the precise m…
View article: Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease
Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease Open
The worldwide prevalence of movement disorders is increasing day by day. Parkinson’s disease (PD) is the most common movement disorder. In general, the clinical manifestations of PD result from dysfunction of the basal ganglia. Although th…