Rajeev Uppal
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View article: Lymphopenia as a diagnostic biomarker in clinical COVID-19: insights from a comprehensive study on SARS-CoV-2 variants
Lymphopenia as a diagnostic biomarker in clinical COVID-19: insights from a comprehensive study on SARS-CoV-2 variants Open
The enduring SARS-CoV-2 pandemic necessitates robust tools for severity assessment. This study, conducted at Islamabad Diagnostic Center across Pakistan from January 2021 to August 2022, aimed to investigate hematological abnormalities amo…
View article: Evaluation of Routine Biomarkers for Identifying Mody in Young-Onset Diabetes: A Retrospective Study from Pakistan Cohort
Evaluation of Routine Biomarkers for Identifying Mody in Young-Onset Diabetes: A Retrospective Study from Pakistan Cohort Open
View article: Bacterial infections and antimicrobial resistance patterns: a comprehensive analysis of health dynamics across regions in Pakistan (2013-2023)
Bacterial infections and antimicrobial resistance patterns: a comprehensive analysis of health dynamics across regions in Pakistan (2013-2023) Open
Antimicrobial resistance (AMR) is a significant public health concern globally, and Pakistan is no exception. The misuse and overuse of antibiotics, inadequate regulation of their sale, and a lack of awareness contribute to the rising leve…
View article: Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan
Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan Open
Rapidly progressive dementias (RPDs) are a type of fatal dementias that cause rapid progression of neuronal dysfunction. This study aimed to assess the prevalence of APOE genotypes (ε2, ε3, ε4) and PRNP mutations (E200K, M129V) in the gene…
View article: Right Coronary artery Myocardial Bridging
Right Coronary artery Myocardial Bridging Open
Myocardial bridge (MB) is a non-atherosclerotic anatomical anomaly of coronary arteries, giving upward thrust to ischemic events. The chief coronary arteries run along the grooves and the heart epicardia surface1. Within such normal distri…
View article: Analytical assessment of clinical sensitivity and specificities of pharmaceutical rapid SARS-CoV-2 detection nasopharyngeal swab testing kits in Pakistan
Analytical assessment of clinical sensitivity and specificities of pharmaceutical rapid SARS-CoV-2 detection nasopharyngeal swab testing kits in Pakistan Open
Despite of the global unity against COVID-19 pandemic, the threat of SARS-CoV-2 variants on the lives of human being is still not over. SARS-CoV-2 pandemic has urged the need of rapid viral detection at earliest. To cope with gradually exp…
View article: Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan
Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan Open
Hepatitis C virus (HCV) presents a significant global health concern, affecting 3.3% of the world's population. The primary mode of HCV transmission is through blood and blood products. Patients with beta thalassemia, who rely on lifelong …
View article: Unveiling diagnostic prowess: a comparative study of exercise treadmill test and CT coronary in coronary artery disease detection in Pakistan (2021-2023)
Unveiling diagnostic prowess: a comparative study of exercise treadmill test and CT coronary in coronary artery disease detection in Pakistan (2021-2023) Open
Coronary Artery Disease (CAD) is a global health concern, with diagnostic modalities and risk factors that exhibit regional variations. This study, conducted at the Islamabad Diagnostic Center, Pakistan, aimed to provide a comprehensive as…
View article: Epidemiological analysis of Leishmaniasis prevalence in Pakistan during 2016-2023
Epidemiological analysis of Leishmaniasis prevalence in Pakistan during 2016-2023 Open
Leishmaniasis, caused by the Leishmania parasite, remains a persistent public health challenge in Pakistan. Despite control efforts, the disease prevalence continues to rise, particularly among pediatric populations. Understanding prevalen…
View article: Cutting-edge: bionanomaterial solutions in the battle against Severe Acute Respiratory Syndrome Coronavirus 2
Cutting-edge: bionanomaterial solutions in the battle against Severe Acute Respiratory Syndrome Coronavirus 2 Open
Amidst the ongoing COVID-19 pandemic, the imperative of our time resides in crafting stratagems of utmost precision to confront the relentless SARS-CoV-2 and quell its inexorable proliferation. A paradigm-shifting weapon in this battle lie…
View article: SARS-CoV-2 clearance in term of Cycle Threshold (Ct) during first two waves of COVID-19 in Pakistan: a phenomenon of delayed viral clearance post-corticosteroid treatment
SARS-CoV-2 clearance in term of Cycle Threshold (Ct) during first two waves of COVID-19 in Pakistan: a phenomenon of delayed viral clearance post-corticosteroid treatment Open
SARS-CoV-2 is recently emerged virus, which caused millions of deaths, all over the world. To tackle COVID-19 pandemic, there is an utmost need for in-depth analysis of viral replication. We aimed to examine viral load in SARS-CoV-2 patien…
View article: Unlocking Hepatitis B and C insights: exploration of risk awareness among university students in the capital twin cities of Pakistan
Unlocking Hepatitis B and C insights: exploration of risk awareness among university students in the capital twin cities of Pakistan Open
Background: Pakistan, a developing nation, grapples with a growing burden of Hepatitis B and C, exerting a substantial strain on the country's economy. Mitigating this challenge necessitates a robust strategy emphasizing prevention of infe…
View article: Hepatitis C virus associated ALT, AST, GGT, Bili T, HB, HBA1C, CREAT, PT, aPPT, AFP, CEA, CA 125, CA 19-9, iPTH biomarkers, computed tomography and HCV burden of disease during pre COVID-19 era (2018-2019) and post COVID-19 era (2020-2022) in Pakistan
Hepatitis C virus associated ALT, AST, GGT, Bili T, HB, HBA1C, CREAT, PT, aPPT, AFP, CEA, CA 125, CA 19-9, iPTH biomarkers, computed tomography and HCV burden of disease during pre COVID-19 era (2018-2019) and post COVID-19 era (2020-2022) in Pakistan Open
The national burden of HCV has significantly mounted over the period of last few decades placing Pakistan at the worst placement of second largest burden of HCV globally. Herein for the first time from Pakistan, we examined clinical correl…
View article: Etiology and Risk Factors for Late Antibiotic De-Escalation and their Effect on Intensive Care Unit Outcome
Etiology and Risk Factors for Late Antibiotic De-Escalation and their Effect on Intensive Care Unit Outcome Open
Background: Timely antibiotic de-escalation is essential in intensive care unit (ICU) to prevent the development of antibiotic resistance. This study was undertaken to identify the causes and observe the effects of late antibiotic de-escal…
View article: An observational study on the effects of delayed initiation of end-of-life care in terminally ill young adults in the intensive care unit
An observational study on the effects of delayed initiation of end-of-life care in terminally ill young adults in the intensive care unit Open
Our study found a high prevalence of delayed initiation of EOL care in terminally ill young adults and identified the factors responsible for them. The normal initiation of EOL care reduced the usage of medications and resources without af…
View article: Effects of Delayed Initiation of End-of-life Care in Terminally Ill Intensive Care Unit Patients
Effects of Delayed Initiation of End-of-life Care in Terminally Ill Intensive Care Unit Patients Open
Choudhuri AH, Sharma A, Uppal R. Effects of Delayed Initiation of End-of-life Care in Terminally Ill Intensive Care Unit Patients. Indian J Crit Care Med 2020;24(6):404-408.
View article: Epidemiology of Multidrug Resistant Infections after Inter ICU Transfer in India
Epidemiology of Multidrug Resistant Infections after Inter ICU Transfer in India Open
Choudhuri AH, Ahuja B, Biswas PS, Uppal R. Epidemiology of Multidrug Resistant Infections after Inter-ICU Transfer in India. Indian Journal of Critical Care Medicine, January 2019;23(1):1-6.
View article: Epidemiology and risk factors for multidrug-resistant bacteria in critically ill patients with liver disease
Epidemiology and risk factors for multidrug-resistant bacteria in critically ill patients with liver disease Open
The study demonstrated a high prevalence of MDR bacterial infection in critically ill patients with a higher mortality over non-MDR bacterial infection and also identified the independent predictors of such infections.
View article: Epidemiology and characteristics of nosocomial infections in critically ill patients in a tertiary care Intensive Care Unit of Northern India
Epidemiology and characteristics of nosocomial infections in critically ill patients in a tertiary care Intensive Care Unit of Northern India Open
Background and Aims: The prevalence of nosocomial infection is higher in the Intensive Care Unit (ICU) than other areas of the hospital. The present observational study was undertaken to describe the epidemiology and characteristics of nos…
View article: Laparoscopic liver surgery program: An early experience from an Indian centre
Laparoscopic liver surgery program: An early experience from an Indian centre Open
View article: A case of malpositioned catheter via supraclavicular approach for subclavian vein cannulation: A rare technique revisited
A case of malpositioned catheter via supraclavicular approach for subclavian vein cannulation: A rare technique revisited Open
Sir, Correct positioning of any central venous catheter (CVC) is a prerequisite for its intended use. The approach of insertion, the technique used, body position and anatomical variability of central veins used for access are important de…
View article: Minimally invasive oesophagectomy in prone versus lateral decubitus position: A comparative study
Minimally invasive oesophagectomy in prone versus lateral decubitus position: A comparative study Open
MIE in the PP is an effective alternative to LDP. The exposure obtained is excellent even without the need for a complete lung collapse, thereby obviating the need for a double-lumen endotracheal tube. A more meticulous dissection can be p…
View article: Epidemiology of ventilator associated pneumonia (vap) in patients with abdominal sepsis
Epidemiology of ventilator associated pneumonia (vap) in patients with abdominal sepsis Open
Abdominal infection leading to sepsis is a major cause of mortality in the ICU. The inflammatory response also alters the pulmonary immunity leading to increased risk for VAP.
View article: Entanglement of Nasogastric Tube and Nasopharyngeal Temperature Probe During Surgery
Entanglement of Nasogastric Tube and Nasopharyngeal Temperature Probe During Surgery Open
Nasogastric tube (NGT) insertion and nasopharyngeal temperature probe (NTP) insertion are routine procedures in patients scheduled for gastric pull or colonic pull surgeries for corrosive esophageal strictures. Although intra-gastric and i…