Rajendra Raghow
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View article: Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS)
Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS) Open
Background Between 5–10% of patients discontinue statin therapy due to statin-associated adverse reactions, primarily statin associated muscle symptoms (SAMS). The absence of a clear clinical phenotype or of biomarkers poses a challenge fo…
View article: Table of Contents
Table of Contents Open
View article: Endothelial Nitric Oxide Synthase–Deficient Mice
Endothelial Nitric Oxide Synthase–Deficient Mice Open
View article: Compensatory Prostaglandin E 2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells
Compensatory Prostaglandin E 2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells Open
Prostaglandin E2 (PGE2) production in immortalized, nontransformed cells derived from wild-type, cyclooxygenase 1–deficient (COX-1−/−) or cyclooxygenase 2–deficient (COX-2−/−) mice was examined after treatment with interleukin (IL)-1β, tum…
View article: Circadian rhythms of hormone secretion and obesity
Circadian rhythms of hormone secretion and obesity Open
The adipose tissue homeostasis is profoundly affected by circadian rhythms of corticosteroid secretion and chronic loss of hormonal oscillations is associated with obesity. How adipose tissue differentially responds to pulsatile vs …
View article: Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats
Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats Open
View article: Gut-brain crosstalk regulates craving for fatty food
Gut-brain crosstalk regulates craving for fatty food Open
Patients undergoing Roux-en-Y gastric bypass (RYGB) surgery elicit striking loss of body weight. Anatomical re-structuring of the gastrointestinal (GI) tract, leading to reduced caloric intake and changes in food preference, are thought to…
View article: Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge
Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge Open
Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience my…
View article: Statins redux: A re-assessment of how statins lower plasma cholesterol
Statins redux: A re-assessment of how statins lower plasma cholesterol Open
Obesity associated dyslipidemia and its negative effects on the heart and blood vessels have emerged as a major healthcare challenge around the globe. The use of statins, potent inhibitors of hydroxyl-methyl glutaryl (HMG) Co-A reductase, …
View article: Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation
Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation Open
Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that regulates genes involved in the de novo lipid synthesis and glycolysis pathways. The structure, turnover and transactivation potential of SREBP-1c a…
View article: Ménage-à-trois of bariatric surgery, bile acids and the gut microbiome
Ménage-à-trois of bariatric surgery, bile acids and the gut microbiome Open
Bariatric surgeries have emerged as highly effective treatments for obesity associated type-2 diabetes mellitus. Evidently, the desired therapeutic endpoints such as rates of weight loss, lower levels of glycated hemoglobin and remission o…