Rajenki Das
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View article: Implementing response-adaptive randomisation in stratified rare-disease trials: Design challenges and practical solutions
Implementing response-adaptive randomisation in stratified rare-disease trials: Design challenges and practical solutions Open
Although response-adaptive randomisation (RAR) has gained substantial attention in the literature, it still has limited use in clinical trials. Amongst other reasons, the implementation of RAR in real world trials raises important practica…
View article: 169. THERAPEUTIC MEMORY RECONSOLIDATION AS A TREATMENT FOR SUBSTANCE USE DISORDERS AND HOW PSYCHEDELICS ARE FACILITATING THIS INTERVENTION: THE UNITY STUDY
169. THERAPEUTIC MEMORY RECONSOLIDATION AS A TREATMENT FOR SUBSTANCE USE DISORDERS AND HOW PSYCHEDELICS ARE FACILITATING THIS INTERVENTION: THE UNITY STUDY Open
Background Maladaptive motivational memory (MMM) is the term given to a learned association between environmental predictors of reward (cues) and the receipt of rewarding stimuli (reward). A key characteristic of MMMs is that they drive ex…
View article: StratosPHere 2: statistical analysis plan for a response-adaptive randomised placebo-controlled phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
StratosPHere 2: statistical analysis plan for a response-adaptive randomised placebo-controlled phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2 Open
Background The StratosPHere 2 trial will evaluate the efficacy of hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2 by focussing on the novel biomarker and other endpoints including safet…
View article: Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets
Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets Open
Variability in case severity and in the range of symptoms experienced has been apparent from the earliest months of the COVID-19 pandemic. From a clinical perspective, symptom variability might indicate various routes/mechanisms by which i…
View article: Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study
Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study Open
It is well-known that mood and pain interact with each other, however individual-level variability in this relationship has been less well quantified than overall associations between low mood and pain. Here, we leverage the possibilities …
View article: Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study
Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study Open
It is well-known that mood and pain interact with each other, however individual-level variability in this relationship has been less well quantified than overall associations between low mood and pain. Here, we leverage the possibilities …
View article: Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets
Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets Open
Through the use of cutting-edge unsupervised classification techniques from statistics and machine learning, we characterise symptom phenotypes among symptomatic SARS-CoV-2 PCR-positive community cases. We first analyse each dataset in iso…
View article: SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission
SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission Open
View article: Challenges in control of COVID-19: short doubling time and long delay to effect of interventions
Challenges in control of COVID-19: short doubling time and long delay to effect of interventions Open
Early assessments of the growth rate of COVID-19 were subject to significant uncertainty, as expected with limited data and difficulties in case ascertainment, but as cases were recorded in multiple countries, more robust inferences could …
View article: Challenges in control of COVID-19: short doubling times and long delay to effect of interventions
Challenges in control of COVID-19: short doubling times and long delay to effect of interventions Open
The unconstrained growth rate of COVID-19 is crucial for measuring the impact of interventions, assessing worst-case scenarios, and calibrating mathematical models for policy planning. However, robust estimates are limited, with scientific…