Rajesh Kumar Radhakrishnan
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View article: B cells inhibit IL-1 family cytokine production and Mycobacterium tuberculosis growth in human CD14+ cells 9263
B cells inhibit IL-1 family cytokine production and Mycobacterium tuberculosis growth in human CD14+ cells 9263 Open
Description The IL-1 superfamily of cytokines (ILSF) produced by antigen-presenting cells plays important roles in Mycobacterium tuberculosis (Mtb) infection. In present study, we infected human monocyte-derived macrophages (MDMs) with Mtb…
View article: Intravenous BCG vaccination provides better protection for neonatal mice than for adult mice infected with Mycobacterium tuberculosis 9221
Intravenous BCG vaccination provides better protection for neonatal mice than for adult mice infected with Mycobacterium tuberculosis 9221 Open
Description Here we compare the immune responses of intravenously (IV) BCG-vaccinated neonatal and adult mice infected with Mycobacterium tuberculosis (Mtb). We found that IV BCG vaccination significantly reduced lung and spleen bacterial …
View article: B cells inhibit IL-1 family cytokine production and <i>Mycobacterium tuberculosis</i> growth in human CD14+ cells
B cells inhibit IL-1 family cytokine production and <i>Mycobacterium tuberculosis</i> growth in human CD14+ cells Open
The IL-1 family of cytokines produced by antigen-presenting cells plays important roles in various diseases and infections, including Mycobacterium tuberculosis (Mtb) infection. In the present study, we infected human monocyte-derived macr…
View article: Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy
Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy Open
View article: Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis
Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis Open
Previously, we found that Mycobacterium tuberculosis (Mtb) infection in type 2 diabetes mellitus (T2DM) mice enhances inflammatory cytokine production which drives pathological immune responses and mortality. In the current study, using a …
View article: CD11b+Ly6g+CD69+CD74+ cells produce interferon-α in <i>Mycobacterium tuberculosis</i> infected alcohol diet-fed mice
CD11b+Ly6g+CD69+CD74+ cells produce interferon-α in <i>Mycobacterium tuberculosis</i> infected alcohol diet-fed mice Open
Chronic alcohol consumption is associated with significant mortality and morbidity in people affected by Mycobacterium tuberculosis (Mtb) infection. Our Lab previously reported that alcohol diet increased mortality in young mice infected w…
View article: HIV-Differentiated Metabolite N-Acetyl-L-Alanine Dysregulates Human Natural Killer Cell Responses to Mycobacterium tuberculosis Infection
HIV-Differentiated Metabolite N-Acetyl-L-Alanine Dysregulates Human Natural Killer Cell Responses to Mycobacterium tuberculosis Infection Open
Mycobacterium tuberculosis (Mtb) has latently infected over two billion people worldwide (LTBI) and caused ~1.6 million deaths in 2021. Human immunodeficiency virus (HIV) co-infection with Mtb will affect the Mtb progression and increase t…
View article: HIV-differentiated metabolite N-Acetyl-L-Alanine dysregulates human natural killer cell responses to<i>Mycobacterium tuberculosis</i>infection
HIV-differentiated metabolite N-Acetyl-L-Alanine dysregulates human natural killer cell responses to<i>Mycobacterium tuberculosis</i>infection Open
Background Mycobacterium tuberculosis ( Mtb ) has latently infected over two billion people worldwide (LTBI) and causes 1.8 million deaths each year. Human immunodeficiency virus (HIV) co-infection with Mtb will affect the Mtb progression …
View article: HIV Infection Increases Plasma Metabolite N-Acetyl-L-Alanine Levels to Dysregulate Human Natural Killer Cell Responses to Mycobacterium Tuberculosis Infection
HIV Infection Increases Plasma Metabolite N-Acetyl-L-Alanine Levels to Dysregulate Human Natural Killer Cell Responses to Mycobacterium Tuberculosis Infection Open
View article: Metabolites enhance innate resistance to human Mycobacterium tuberculosis infection
Metabolites enhance innate resistance to human Mycobacterium tuberculosis infection Open
To determine the mechanisms that mediate resistance to Mycobacterium tuberculosis (M. tuberculosis) infection in household contacts (HHCs) of patients with tuberculosis (TB), we followed 452 latent TB infection-negative (LTBI-) HHCs for 2 …
View article: Retraction Note: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
Retraction Note: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection Open
View article: Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk
Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk Open
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View article: Correction: IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis
Correction: IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis Open
[This corrects the article DOI: 10.1371/journal.ppat.1008140.].
View article: POS-060 CHRONIC KIDNEY DISEASE IN PEDIATRIC ACUTE KIDNEY INJURY SURVIVORS FROM INTENSIVE CARE UNIT: PROSPECTIVE STUDY FROM A DEVELOPING COUNTRY
POS-060 CHRONIC KIDNEY DISEASE IN PEDIATRIC ACUTE KIDNEY INJURY SURVIVORS FROM INTENSIVE CARE UNIT: PROSPECTIVE STUDY FROM A DEVELOPING COUNTRY Open
Acute kidney injury (AKI) is an independent risk factor for mortality in critically il. Incidence of AKI in PICU ranges from 8-30%. Despite advances in therapy, mortality is still high and survivors are at risk of CKD.
View article: RETRACTED ARTICLE: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
RETRACTED ARTICLE: Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection Open
View article: BCG vaccination reduces the mortality of Mycobacterium tuberculosis–infected type 2 diabetes mellitus mice
BCG vaccination reduces the mortality of Mycobacterium tuberculosis–infected type 2 diabetes mellitus mice Open
Diabetes is a significant risk factor for the development of active tuberculosis. In this study, we used a mouse model of type 2 diabetes mellitus (T2DM) to determine the effect of prior Bacillus Calmette-Guérin (BCG) vaccination on immune…
View article: Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction
Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction Open
Aims: Redox homeostasis is tightly controlled and regulates key cellular signaling pathways. The cell's antioxidant response provides a natural defense against oxidative stress, but excessive antioxidant generation leads to r…
View article: IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis
IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis Open
[This corrects the article DOI: 10.1371/journal.ppat.1008140.].
View article: Cardiac resynchronization therapy is associated with improvement in clinical outcomes in Indian heart failure patients: Results of a large, long-term observational study
Cardiac resynchronization therapy is associated with improvement in clinical outcomes in Indian heart failure patients: Results of a large, long-term observational study Open
The results from the SASHFR registry show a clear superiority of CRT over optimal pharmacological therapy in terms of improvement in clinical conditions among HF patients. The low rate of CRT acceptance, in patients indicated to this thera…
View article: Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis
Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis Open
In the current study, we used a mouse model and human blood samples to determine the effects of chronic alcohol consumption on immune responses during Mycobacterium tuberculosis (Mtb) infection. Alcohol increased the mortality of young mic…
View article: c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice
c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice Open
View article: Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection
Interleukin-21 Regulates Natural Killer Cell Responses During Mycobacterium tuberculosis Infection Open
These findings suggest that activated T cells enhance NK cell responses to lyse Mtb-infected human monocytes and restrict Mtb growth in monocytes through IL-21 production. Interleukin-21-activated NK cells also enhance the immune response …
View article: Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease
Osteoporotic fractures in patients with systemic lupus erythematosus and end stage renal disease Open
Background The incidence of end stage renal disease (ESRD) in patients with systemic lupus erythematosus (SLE) is rising. However, the relationship between osteoporotic fractures and SLE in the setting of ESRD remains uninvestigated. The p…
View article: Profiling cardiac arrhythmia and heart failure patients in India: The Pan-arrhythmia and Heart Failure Observational Study
Profiling cardiac arrhythmia and heart failure patients in India: The Pan-arrhythmia and Heart Failure Observational Study Open
The India PANARM HF study provides new information and insights into the demographic, clinical, interventional therapy, referral and consultation pattern profiles of CA/HF patients in India.
View article: Effect of Thoracic Correction Exercises in Upper Body Dysfunction of 94-Year-old Male Participant – A Case Report
Effect of Thoracic Correction Exercises in Upper Body Dysfunction of 94-Year-old Male Participant – A Case Report Open
The case report has been presented to show the effects of thoracic correction exercises on flexed posture in older men with upper body dysfunction using posture analysis software and pectoralis minor muscle length test. The present case is…