Explanipedia

Comparing the respiratory tract microbiome in captive elephants and humans in Chitwan National Park: Implications for conservation medicine Open

Rajesh Man Rajbhandari, Prajwol Manandhar, Rajindra Napit, Amir Sadaula, Ashok Chaudhary , et al. · 2025

The study of gut microbiome in both animals and humans living in proximity has proven crucial in understanding their coevolution, the potential for microbial transfer and the dynamics behind various diseases. Similarly, the investigation o…

Integrated One Health Surveillance of Zoonotic Diseases at the Wildlife-Human Interface: How Pathogen Detection Informs Spillover Risks and Transmission Dynamics Open

Rajindra Napit, Binod Khadka, Badri Bahadur Khadka, Roji Raut, Pei Yee Woh , et al. · 2025

Emerging infectious diseases (EIDs) pose a significant global health challenge, with zoonotic pathogens— transmitted from animals to humans—accounting for about 75% of these threats. Traditionally, responses to EIDs have been reactive, foc…

Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer dynamics Open

Rajindra Napit, Anupama Gurung, Ajit Poudel, Ashok Chaudhary, Prajwol Manandhar , et al. · 2025

Gut microbiota diversity among humans, elephants, livestock and wild herbivores in Chitwan National Park bears implications for conservation medicine Open

Rajesh Man Rajbhandari, Giovanni Forcina, Prajwol Manandhar, Pragun G Rajbhandari, Rajindra Napit , et al. · 2025

Gut microbiome influences host health and well-being. Co-occurring hosts may exchange disease-causing bacteria belonging to these microbial communities. Therefore, monitoring gut microbiota composition in wildlife and humans is paramount t…

Feeding Habits of Leopards and Leopard Cats in the Fragmented Forests Surrounding the Kathmandu Valley Open

Prajwol Manandhar, Keren S. Pereira, Naresh Kusi, Jyoti Joshi, Noam Levin , et al. · 2025

Large‐scale anthropogenic developments in the metropolitan areas of Nepal and the rural to urban influx of people have exacerbated human–wildlife conflicts across human‐altered landscapes of Nepal. The Kathmandu Valley has experienced larg…

Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer dynamics Open

Rajindra Napit, Anupama Gurung, Ajit Poudel, Ashok Chaudhary, Prajwol Manadhar , et al. · 2024

Antimicrobial resistance (AMR) is a rapidly emerging global health crisis, projected to cause 10.2 million deaths annually by 2050. The unregulated and indiscriminate use of antibiotics is driving the swift emergence and spread of AMR, a p…

Shared infections at the wildlife–livestock interface and their impact on public health, economy, and biodiversity Open

Dibesh Karmacharya, Gloria Herrero‐García, Bibhu Luitel, Rajesh Man Rajbhandari, Ana Balseiro · 2024

10 páginas, 4 figuras, 1 tabla.

Prevalence of viral load suppression and acquired drug resistance among people living with HIV in Nepal: a nationally representative surveillance study Open

Keshab Deuba, Gopal Panta, Rajesh Man Rajbhandari, Romaisa Kunwar, Tara Nath Pokhrel , et al. · 2023

Natural Clerodendrum-derived tick repellent: learning from Nepali culture Open

Lorena Mazuecos, Marinela Contreras, Paul D. Kasaija, Prajwol Manandhar, Weronika Grąźlewska , et al. · 2023

Ticks attaching to ear canals of humans and animals are the cause of otoacariasis, common in rural areas of Nepal. The plant Clerodendrum viscosum is used in multiple indigenous systems of medicine by ethnic communities in the Indo-Nepali-…

Phylogenomic analysis supports Mycobacterium tuberculosis transmission between humans and elephants Open

Rajesh Man Rajbhandari, Rajindra Napit, Prajwol Manandhar, Roji Raut, Anupama Gurung , et al. · 2023

Introduction Tuberculosis is an infectious disease caused by a group of acid-fast bacilli known as Mycobacterium tuberculosis complex (MTC), which has a major impact on humans. Transmission of MTC across the human-animal interface has been…

High prevalence of Bovine Tuberculosis reported in Cattle and Buffalo of Eastern Nepal Open

Nabin Upadhyaya, Nisha Shrestha, Roshan Dahal, Sanjay Kumar Yadav, Rashmi Thakur , et al. · 2023

Livestock farming, specifically of cattle and buffalo, is crucial to Nepal’s economy, with more than 66% of the population involved in agriculture and animal husbandry. Animal tuberculosis (TB) caused by Mycobacterium bovis is a chronic di…

Rapid genomic surveillance of SARS-CoV-2 in a dense urban community of Kathmandu Valley using sewage samples Open

Rajindra Napit, Prajwol Manandhar, Ashok Chaudhary, Bishwo Shrestha, Ajit Poudel , et al. · 2023

Understanding disease burden and transmission dynamics in resource-limited, low-income countries like Nepal are often challenging due to inadequate surveillance systems. These issues are exacerbated by limited access to diagnostic and rese…

One Health Assessment of an Urban Temporary Settlement Reveals Gut Microbiome Serving as Antimicrobial Resistance Gene Reservoir Open

Rajindra Napit, Anupama Gurung, Ajit Poudel, Prajwol Manadhar, Ashok B. Chaudhary , et al. · 2023

Antimicrobial resistance (AMR) is an emerging and growing global health challenge that could result in 10.2 million deaths annually by 2050. The unrestricted and haphazard use of antibiotics is contributing to the rapid emergence and sprea…

Newcastle disease burden in Nepal and efficacy of Tablet I2 vaccine in commercial and backyard poultry production Open

Rajindra Napit, Ajit Poudel, Saman Man Pradhan, Prajwol Manandhar, Sajani Ghaju , et al. · 2023

Poultry ( Gallus domesticus ) farming plays an important role as an income generating enterprise in a developing country like Nepal, contributing more than 4% to the national Gross Domestic Product (GDP). Newcastle Disease (ND) is a major …

Differentially Represented Proteins in Response to Infection with Mycobacterium tuberculosis Identified by Quantitative Serum Proteomics in Asian Elephants Open

Margarita Villar, Rajesh Man Rajbhandari, Sara Artigas-Jerónimo, Marinela Contreras, Amir Sadaula , et al. · 2022

Tuberculosis is a major global concern. Tuberculosis in wildlife is a risk for zoonotic transmission and becoming one of the challenges for conservation globally. In elephants, the number of cases is likely rising. The aim of this study wa…

Understanding Mycobacterium tuberculosis complex in elephants through a One Health approach: a systematic review Open

Rajesh Man Rajbhandari, José de la Fuente, Dibesh Karmacharya, Sujala Mathema, Bijay Maharjan , et al. · 2022

Background Mycobacterium tuberculosis complex (MTC) that causes the chronic infectious disease- tuberculosis (TB), often presents with a complicated epidemiological pattern where the transmission chain may include humans, domestic animals …

Newcastle disease burden in Nepal and efficacy of Tablet I-2 vaccine in commercial and backyard poultry production Open

Rajindra Napit, Ajit Poudel, Saman Man Pradhan, Prajwol Manandhar, Sajani Ghaju , et al. · 2022

Poultry ( Gallus domesticus ) farming plays an important role as an income generating enterprise in a developing country like Nepal, contributing more than 4% to the national GDP. It is also one of the major sources of protein for growing …

Who gets vaccinated in a measles-rubella campaign in Nepal?: results from a post-campaign coverage survey Open

M. Carolina Danovaro‐Holliday, Dale A. Rhoda, Mona Lacoul, Mary L. Prier, Jhalak Sharma Gautam , et al. · 2022

Addressing disruptions in childhood routine immunisation services during the COVID-19 pandemic: perspectives from Nepal, Senegal and Liberia Open

Sameer Dixit, Moussa Sarr, Daouda Gueye, Kyle Muther, T. Ruston Yarnko , et al. · 2021

### Summary box RI emerged as one the most disrupted health services in early-2020 to mid-2020,1 a global systems shock associated with the COVID-19 pandemic. In May 2020, an estimated 80 million children were thought to be affected by in…

Rapid genomic surveillance of SARS-CoV-2 in a dense urban community using environmental (sewage) samples Open

Rajindra Napit, Prajwol Manandhar, Ashok Chaudhary, Bishwo Shrestha, Ajit Poudel , et al. · 2021

Understanding disease burden and transmission dynamics in resource-limited, developing countries like Nepal is often challenging due to a lack of adequate surveillance systems. These issues are exacerbated by limited access to diagnostic a…

Addressing disruptions in childhood routine immunisation services during the COVID-19 pandemic: perspectives and lessons learned from Liberia, Nepal, and Senegal Open

Sameer Dixit, Moussa Sarr, Daouda Gueye, Kyle Muther, T. Ruston Yarnko , et al. · 2021

The COVID-19 pandemic has inflicted multifaceted disruptions to routine immunisation from global to local levels, affecting every aspect of vaccine supply, access, and demand. Since March 2020, country programmes have implemented a range o…

Health Reporting Characteristics among Journalists in Nepal Utilizing a One Health Framework Open

Jessica S. Schwind, Stephanie A. Norman, Munshi Khaledur Rahman, Holly L. Richmond, Sameer Dixit , et al. · 2021

Journalists play a crucial role in the dissemination of health-related information. In developing countries, such as Nepal, the media are integral in shaping the national agenda and informing the public of important health issues. With an …

Trends and determinants of HIV transmission among men who inject drugs in the Pokhara Valley, Nepal: analysis of cross-sectional studies Open

Sam Hogan, Andrew Page, Felix Akpojene Ogbo, Sameer Dixit, Rajesh Man Rajbhandari , et al. · 2021

Trends and determinants of HIV transmission among men who inject drugs in the Pokhara Valley, Nepal: Analysis of cross-sectional studies Open

Sam Hogan, Andrew Page, Felix Akpojene Ogbo, Sameer Dixit, Rajesh Man Rajbhandari , et al. · 2020

Background HIV is a major public health issue around the world, especially in developing countries. Although the overall prevalence of HIV in Nepal is relatively low, there are specific sub-populations where the prevalence is far higher th…

Hepatitis C (HCV) therapy for HCV mono-infected and HIV-HCV co-infected individuals living in Nepal Open

Sudhamshu KC, Holly Murphy, Sameer Dixit, Apurva Rai, Bickram Pradhan , et al. · 2020

Background Despite direct-acting antivirals (DAA), aims to “eradicate” viral hepatitis by 2030 remain unlikely. In Nepal, an expert consortium was established to treat HCV through Nepal earthquakes aftermath offering a model for HCV treatm…

Vulnerabilities for Exposure to Emerging Infectious Disease at Urban Settlements in Nepal Open

David J. Wolking, Dibesh Karmacharya, Manisha Bista, Rima Shrestha, Pranav Pandit , et al. · 2020

Trends and determinants of HIV transmission among men who inject drugs in the Pokhara Valley, Nepal: Analysis of cross-sectional studies Open

Sam Hogan, Andrew Page, Felix Akpojene Ogbo, Sameer Dixit, Rajesh Man Rajbhandari , et al. · 2020

Background HIV is a major public health issue around the world, especially in developing countries. Although the overall prevalence of HIV in Nepal is relatively low and the country itself is considered low risk, there are specific sub-pop…

Trends and determinants of HIV transmission among men who inject drugs in the Pokhara Valley, Nepal: Analysis of cross-sectional studies Open

Sam Hogan, Andrew Page, Felix Akpojene Ogbo, Sameer Dixit, Rajesh Man Rajbhandari , et al. · 2020

Background HIV is a major public health issue around the world, especially in developing countries. Although the overall prevalence of HIV in Nepal is relatively low and the country itself is considered low risk, there are specific sub-pop…

Trends and determinants of HIV transmission among men who inject drugs in the Pokhara Valley, Nepal Open

Sam Hogan, Andrew Page, Felix Akpojene Ogbo, Sameer Dixit, Rajesh Man Rajbhandari , et al. · 2020

Background HIV is a major public health issue around the world, especially in developing countries. Although the overall prevalence of HIV in Nepal is relatively low and the country itself is considered low risk, there are specific sub-pop…

Correction: Surveillance of Influenza A Virus and Its Subtypes in Migratory Wild Birds of Nepal Open

Dibesh Karmacharya, Sulochana Manandhar, Ajay Sharma, Tarka Raj Bhatta, Pratikshya Adhikari , et al. · 2019

[This corrects the article DOI: 10.1371/journal.pone.0133035.].

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