Rajesh Sreedharan Nair
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View article: In vitro skin permeation and rheological evaluation of a transethosomal formulation containing curcumin-tocotrienol combinations for enhanced topical applications
In vitro skin permeation and rheological evaluation of a transethosomal formulation containing curcumin-tocotrienol combinations for enhanced topical applications Open
View article: Optimizing In Vitro Skin Permeation Studies to Obtain Meaningful Data in Topical and Transdermal Drug Delivery
Optimizing In Vitro Skin Permeation Studies to Obtain Meaningful Data in Topical and Transdermal Drug Delivery Open
Drug delivery through the skin provides several advantages over other administration routes, including the avoidance of first-pass metabolism and gastrointestinal side effects, prolonged drug release, and significant improvement in patient…
View article: Mechanistic Insights into the Inhibition of Colorectal Cancer by BuShenFang through Adenomatous Polyposis Coli Expression and Wnt/β-catenin Pathway Regulation
Mechanistic Insights into the Inhibition of Colorectal Cancer by BuShenFang through Adenomatous Polyposis Coli Expression and Wnt/β-catenin Pathway Regulation Open
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Despite advances in chemotherapy and radiotherapy, significant side effects persist, prompting the exploration of alternative therapies such a…
View article: Optimization and Evaluation of Floating Raft System-Based Bilayer Tablets for Third-Line Therapy of H. Pylori Infection Using Amoxicillin Trihydrate, Rifabutin, and Omeprazole
Optimization and Evaluation of Floating Raft System-Based Bilayer Tablets for Third-Line Therapy of H. Pylori Infection Using Amoxicillin Trihydrate, Rifabutin, and Omeprazole Open
View article: Exploring the anti-inflammatory activities, mechanism of action and prospective drug delivery systems of tocotrienol to target neurodegenerative diseases
Exploring the anti-inflammatory activities, mechanism of action and prospective drug delivery systems of tocotrienol to target neurodegenerative diseases Open
A major cause of death in the elderly worldwide is attributed to neurodegenerative diseases, such as AD (Alzheimer’s disease), PD (Parkinson’s disease), ALS (Amyotrophic lateral sclerosis), FRDA (Friedreich’s ataxia), VaD (Vascular dementi…
View article: Development and Evaluation of Fast Dissolving Oral Films of Mefenamic Acid for the Management of Fever
Development and Evaluation of Fast Dissolving Oral Films of Mefenamic Acid for the Management of Fever Open
The marketed formulations of Mefenamic Acid (MA) used for the treatment of fever in the paediatric population are reported to have several drawbacks. This study aimed to develop and evaluate the mefenamic acid–loaded oral dispersible films…
View article: Development and Characterisation of an Optimised Toothpaste of Achyranthes aspera plant extract for the Effective Protection from Dental Black Stain forming Chromogenic bacteria species
Development and Characterisation of an Optimised Toothpaste of Achyranthes aspera plant extract for the Effective Protection from Dental Black Stain forming Chromogenic bacteria species Open
The dental black stain (BS) is formed due to the colonisation of chromogenic bacteria, which is commonly reported in the population at the pre-puberty age. The currently available methods for black stain prevention such as dental scaling, …
View article: Validation of methods for pesticide residue analysis in milk and milk products asper FSSAI regulation
Validation of methods for pesticide residue analysis in milk and milk products asper FSSAI regulation Open
Accurate analysis of 55 pesticides as per the regulatory requirement of FSSAI for milk and milk products is a challenging task as it requires performing six different types of extractions and detection techniques. Further, before putting t…
View article: Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance
Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance Open
Amphotericin B is an effective polyene antifungal considered as a “gold standard” in the management of fungal infections. Currently, it is administered mainly by IV due to poor aqueous solubility, which precludes its delivery orally. Parad…
View article: Revisiting the concept of incretin and enteroendocrine L-cells as type 2 diabetes mellitus treatment
Revisiting the concept of incretin and enteroendocrine L-cells as type 2 diabetes mellitus treatment Open
View article: Characterization and <i>ex vivo</i> evaluation of curcumin nanoethosomes for melanoma treatment
Characterization and <i>ex vivo</i> evaluation of curcumin nanoethosomes for melanoma treatment Open
This study aimed at developing curcumin nanoethosomes (Cur-Ets) with superior skin permeation intended for melanoma treatment. Although curcumin is active against many types of skin cancers, a suitable topical formulation is still lacking …
View article: An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M<sup>®</sup> membrane and excised human skin
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M<sup>®</sup> membrane and excised human skin Open
Tocotrienol (TRF) ethosomes were developed and evaluated in vitro for potential transdermal delivery against melanoma. The optimised TRF ethosomal size ranged between 64.9 ± 2.2 nm to 79.6 ± 3.9 nm and zeta potential (ZP) between -5…
View article: Development and Rheological Evaluation of DEET (N,N-DiethyL-3-Methylbenzamide) Microparticles Loaded Hydrogel For Topical Application
Development and Rheological Evaluation of DEET (N,N-DiethyL-3-Methylbenzamide) Microparticles Loaded Hydrogel For Topical Application Open
A significantly low DEET permeation from the microparticle formulations indicated minimal absorption of the drug into the body and thus, reduced systemic toxicity. Thixotropic evaluation of the hydrogel formulation demonstrated a hysteresi…
View article: Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview
Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview Open
: Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal …
View article: Management of antipsychotic-induced hyperprolactinaemia
Management of antipsychotic-induced hyperprolactinaemia Open
Summary Hyperprolactinaemia is a common endocrine disorder that can be associated with significant morbidity. Antipsychotic medications are frequently linked to hyperprolactinaemia. This disorder usually presents as menstrual problems in w…
View article: <i>In vitro</i> assessment of non-irritant microemulsified voriconazole hydrogel system
<i>In vitro</i> assessment of non-irritant microemulsified voriconazole hydrogel system Open
Research was aimed on microemulsion-based hydrogel for voriconazole. Oleic acid and isopropyl myristate as lipid phases; tween 20: tween 80 as surfactants and PEG600 as cosurfactant were selected to formulate voriconazole microemulsions. T…
View article: Cold Atmospheric Plasma in Dentistry
Cold Atmospheric Plasma in Dentistry Open
Introduction Plasma is the fourth state of matter and others are liquid, gas, and solid. Plasma occurs as a natural phenomenon in the universe and appears in the form of fire, in the polar aurora borealis and in the nuclear fusion reaction…