Dev Chandra
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View article: Linking GABAA receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication
Linking GABAA receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication Open
View article: Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis
Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis Open
GABAergic transmission regulates adult neurogenesis by exerting negative feedback on cell proliferation and enabling dendrite formation and outgrowth. Further, GABAergic synapses target differentiating dentate gyrus granule cells prior to …
View article: α4-Containing GABAA Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513
α4-Containing GABAA Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513 Open
Alcohol (ethanol) is widely consumed for its desirable effects but unfortunately has strong addiction potential. Some imidazobenzodiazepines such as Ro15-4513 are able to antagonize many ethanol-induced behaviors. Controversial biochemical…
View article: Subunit Compensation and Plasticity of Synaptic GABAA Receptors Induced by Ethanol in ?4 Subunit Knockout Mice
Subunit Compensation and Plasticity of Synaptic GABAA Receptors Induced by Ethanol in ?4 Subunit Knockout Mice Open
There is considerable evidence that ethanol (EtOH) potentiates γ-aminobutyric acid type A receptor (GABA(A)R) action, but only GABA(A)Rs containing δ subunits appear sensitive to low millimolar EtOH. The α4 and δ subunits co-assemble into …
View article: Prototypic GABAA Receptor Agonist Muscimol Acts Preferentially Through Forebrain High-Affinity Binding Sites
Prototypic GABAA Receptor Agonist Muscimol Acts Preferentially Through Forebrain High-Affinity Binding Sites Open
View article: Trace and contextual fear conditioning is enhanced in mice lacking the α4 subunit of the GABAA receptor
Trace and contextual fear conditioning is enhanced in mice lacking the α4 subunit of the GABAA receptor Open
View article: Gamma-Aminobutyric Acid Type A Receptor Alpha 4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane
Gamma-Aminobutyric Acid Type A Receptor Alpha 4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane Open
These results lend support to the hypothesis that different sites of action mediate different anesthetic end points and suggest that alpha4-containing GABA(A)-Rs are important mediators of the amnestic effect of isoflurane on hippocampal-d…
View article: Brain regional distribution of GABAA receptors exhibiting atypical GABA agonism: Roles of receptor subunits
Brain regional distribution of GABAA receptors exhibiting atypical GABA agonism: Roles of receptor subunits Open
View article: Investigation of ethanol-induced impairment of spatial memory in γ2 heterozygous knockout mice
Investigation of ethanol-induced impairment of spatial memory in γ2 heterozygous knockout mice Open
View article: Ethanol Modulates Synaptic and Extrasynaptic GABAA Receptors in the Thalamus
Ethanol Modulates Synaptic and Extrasynaptic GABAA Receptors in the Thalamus Open
View article: Extrasynaptic GABA Type A Receptors in the Mechanism of Action of Ethanol
Extrasynaptic GABA Type A Receptors in the Mechanism of Action of Ethanol Open
The gamma-aminobutyric acid (GABA) Type A receptor (GABAA-R) mediates the majority of rapid inhibition in the central nervous system and is the site of action for many clinically used drugs. GABAA-R mediated inhibition can occur via the co…
View article: Taurine Is a Potent Activator of Extrasynaptic GABA<sub>A</sub>Receptors in the Thalamus
Taurine Is a Potent Activator of Extrasynaptic GABA<sub>A</sub>Receptors in the Thalamus Open
Taurine is one of the most abundant free amino acids in the brain. In a number of studies, taurine has been reported to activate glycine receptors (Gly-Rs) at moderate concentrations (≥100 μ m ), and to be a weak agonist at GABA A receptor…
View article: Normal Acute Behavioral Responses to Moderate/High Dose Ethanol in GABA<sub>A</sub>Receptor α4 Subunit Knockout Mice
Normal Acute Behavioral Responses to Moderate/High Dose Ethanol in GABA<sub>A</sub>Receptor α4 Subunit Knockout Mice Open
Background: γ‐Aminobutyric acid type A receptors (GABA A ‐Rs) have been implicated in mediating some of the behavioral effects of ethanol (EtOH), but the contribution of specific GABA A ‐R subunits is not yet fully understood. The GABA A ‐…
View article: Functional Consequences of GABA<sub>A</sub>Receptor α4 Subunit Deletion on Synaptic and Extrasynaptic Currents in Mouse Dentate Granule Cells
Functional Consequences of GABA<sub>A</sub>Receptor α4 Subunit Deletion on Synaptic and Extrasynaptic Currents in Mouse Dentate Granule Cells Open
Background: The α4 subunit‐containing γ‐aminobutyric acid (A) receptors (GABA A Rs) are highly expressed primarily at extrasynaptic sites in the dentate gyrus (DG) and thalamus and are suspected to contribute to tonic inhibition that is se…
View article: GABA<sub>A</sub>receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
GABA<sub>A</sub>receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol Open
The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation of subsynaptic GABA A receptors (GABA A -Rs), or via continuous activation of hig…
View article: GABAAreceptor γ2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines
GABAAreceptor γ2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines Open