Rajiv R. Mohan
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View article: Epigenetic Reprogramming Via Sodium Butyrate Induces Corneal Myofibroblast Dedifferentiation In Vitro and Inhibits Fibrosis In Vivo
Epigenetic Reprogramming Via Sodium Butyrate Induces Corneal Myofibroblast Dedifferentiation In Vitro and Inhibits Fibrosis In Vivo Open
Dedifferentiation of CMFs via epigenetic reprogramming by NaB offers an attractive approach to treat corneal fibrosis in vivo. Additional studies are warranted.
View article: Current progress in research on ocular injury caused by exposure to vesicants
Current progress in research on ocular injury caused by exposure to vesicants Open
Vesicants, powerful chemical weapons of mass destruction, are agents that cause blistering of the skin and blindness upon accidental exposure or during warfare. In addition, their exposure induces a wide range of other symptoms, including …
View article: Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo
Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo Open
This study provides an integrative transcriptomic framework of stromal cell heterogeneity, intercellular signaling, and ECM remodeling trajectories in rabbit cornea in vivo and advances mechanistic understanding of corneal repair.
View article: Open-Field Blast Injury Disrupts Corneal Gene Expression Linked to Ion Transport, Sensory Perception, and Neural Signaling
Open-Field Blast Injury Disrupts Corneal Gene Expression Linked to Ion Transport, Sensory Perception, and Neural Signaling Open
OFBI led to significant disruptions in corneal transcriptome critical in the modulation of ion channel activity, sensory perception, and neurotransmitter signaling.
View article: Artificial intelligence derived grading of mustard gas induced corneal injury and opacity
Artificial intelligence derived grading of mustard gas induced corneal injury and opacity Open
Artificial intelligence (AI) has emerged as a transformative tool in ophthalmology for disease diagnosis and prognosis. However, use of AI for assessing corneal damage due to chemical injury in live rabbits remains lacking. This study aime…
View article: The Role of Decorin in the Ocular Surface: Structure, Function, and Therapeutic Potential
The Role of Decorin in the Ocular Surface: Structure, Function, and Therapeutic Potential Open
The ocular surface, comprising the cornea, conjunctiva, and sclera, relies on a complex extracellular matrix (ECM) for structural support and functional integrity. Decorin (DCN), a small leucine‐rich proteoglycan, a key ECM component invol…
View article: Targeted delivery of thymoquinone-encapsulated polyethyleneimine/poly (lactic acid) nanoparticles into breast cancer cells
Targeted delivery of thymoquinone-encapsulated polyethyleneimine/poly (lactic acid) nanoparticles into breast cancer cells Open
Breast cancer is the most often diagnosed cancer globally, affecting elderly women predominantly. Thymoquinone (TQ) is a potential anticancer agent; however, its pharmacological applications are restricted by inadequate aqueous solubility …
View article: An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis
An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis Open
This review catalogues the epidemiological, clinical, and morphological traits of rare fungi implicated in atypical MK and also provides a global prevalence estimate. Further, it emphasizes the role of implementation of specialized diagnos…
View article: Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling
Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling Open
The results of in vivo and in vitro investigations uncovered a novel mechanism that mustard gas toxicity to the cornea involves ferroptosis pathway and p38 MAPK activation.
View article: Anti‐fibrotic effects of lisinopril (<scp>ACE</scp> inhibitor) and fasudil (<scp>ROCK</scp> inhibitor) in combination for canine corneal fibrosis in vitro
Anti‐fibrotic effects of lisinopril (<span>ACE</span> inhibitor) and fasudil (<span>ROCK</span> inhibitor) in combination for canine corneal fibrosis in vitro Open
Background Corneal fibrosis is a leading cause of blindness in mammalian species and may result in compromised performance in sports and daily functions. This study evaluated the safety and anti‐fibrotic effects of the FDA‐approved drugs, …
View article: Transcriptomic landscape of quiescent and proliferating human corneal stromal fibroblasts
Transcriptomic landscape of quiescent and proliferating human corneal stromal fibroblasts Open
View article: RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing
RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing Open
This study identified several novel genes involved in myofibroblast development, offering potential targets for developing newer therapeutic strategies for corneal fibrosis.
View article: Analysis of Smad3 in the modulation of stromal extracellular matrix proteins in corneal scarring after alkali injury.
Analysis of Smad3 in the modulation of stromal extracellular matrix proteins in corneal scarring after alkali injury. Open
The significant changes in profibrotic genes and stromal ECM proteins revealed a direct role of Smad3 in stromal ECM proteins and TGFβ/Smad-driven wound healing. Smad3 appears to be an attractive molecular target for limiting abnormal stro…
View article: Viral infections and pathogenesis of glaucoma: a comprehensive review
Viral infections and pathogenesis of glaucoma: a comprehensive review Open
Glaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory cond…
View article: Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools
Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools Open
View article: Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases
Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases Open
Retinal diseases are one of the leading causes of blindness globally. The mainstay treatments for these blinding diseases are laser photocoagulation, vitrectomy, and repeated intravitreal injections of anti-vascular endothelial growth fact…
View article: Toxicological effects of ocular acrolein exposure to eyelids in rabbits in vivo
Toxicological effects of ocular acrolein exposure to eyelids in rabbits in vivo Open
View article: Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea
Mustard Gas Exposure Actuates SMAD2/3 Signaling to Promote Myofibroblast Generation in the Cornea Open
Sulfur mustard gas (SM) is a vesicating and alkylating agent used as a chemical weapon in many mass-casualty incidents since World War I. Ocular injuries were reported in >90% of exposed victims. The mechanisms underlying SM-induced blindn…
View article: Corneal gene therapy: Structural and mechanistic understanding
Corneal gene therapy: Structural and mechanistic understanding Open
View article: Corneal Regeneration Using Gene Therapy Approaches
Corneal Regeneration Using Gene Therapy Approaches Open
One of the most remarkable advancements in medical treatments of corneal diseases in recent decades has been corneal transplantation. However, corneal transplants, including lamellar strategies, have their own set of challenges, such as gr…
View article: Corneal injury is associated with stromal and vascular alterations within cranial dura mater
Corneal injury is associated with stromal and vascular alterations within cranial dura mater Open
The cornea and cranial dura mater share sensory innervation. This link raises the possibility that pathological impulses mediated by corneal injury may be transmitted to the cranial dura, trigger dural perivascular/connective tissue nocice…
View article: Mustard gas exposure instigates retinal Müller cell gliosis
Mustard gas exposure instigates retinal Müller cell gliosis Open
View article: Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface Open
Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surfa…
View article: Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery
Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery Open
Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but they are associated with high complication rates and sur…
View article: Role of aquaporins in corneal healing post chemical injury
Role of aquaporins in corneal healing post chemical injury Open
View article: Therapeutic Profile of Human Umbilical Cord Blood Serum and Autologous Serum Therapies in Treatment of Ocular Surface Disorders: A Pilot Study
Therapeutic Profile of Human Umbilical Cord Blood Serum and Autologous Serum Therapies in Treatment of Ocular Surface Disorders: A Pilot Study Open
Purpose: Umbilical cord blood serum (UCBS) is an effective adjunctive treatment along with conventional therapy in ocular surface disorders (OSDs). It aids in rapid ocular surface restoration thereby achieving epithelial inte…
View article: Carbofuran pesticide toxicity to the eye
Carbofuran pesticide toxicity to the eye Open
View article: Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids
Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids Open
Placental growth factor (PlGF) and Angiopoietin (Ang)-1 are two proteins that are involved in the regulation of endothelial cell (EC) growth and vasculature formation. In the retina and endothelial cells, pericytes are the major source of …
View article: Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury
Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury Open
View article: Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure
Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure Open