Rajkishor Nishad
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View article: The <i>Drosophila</i> Nesprin-1 homolog MSP300 is required for muscle autophagy and proteostasis
The <i>Drosophila</i> Nesprin-1 homolog MSP300 is required for muscle autophagy and proteostasis Open
Nesprin proteins, which are components of the linker of nucleoskeleton and cytoskeleton (LINC) complex, are located within the nuclear envelope and play prominent roles in nuclear architecture. For example, LINC complex proteins interact w…
View article: Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin
Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin Open
Retinal neurons that form ribbon-style synapses operate over a wide dynamic range, continuously relaying visual information to their downstream targets. The remarkable signaling abilities of these neurons are supported by specialized presy…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 34/2022
Graphisches Inhaltsverzeichnis: Angew. Chem. 34/2022 Open
This Minireview covers some of the recent advances in the development of small chemical tags for optical bioimaging, from their chemical synthesis and characterization to their application in different biological systems, such as cells, ti…
View article: Growth hormone induces TNF-α in podocytes and contributes to monocyte-to-macrophage differentiation: Implications in Diabetic kidney disease
Growth hormone induces TNF-α in podocytes and contributes to monocyte-to-macrophage differentiation: Implications in Diabetic kidney disease Open
Diabetes shortens the life expectancy by more than a decade, and the excess mortality in diabetes is correlated with the incidence of kidney disease. Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. In human …
View article: Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria
Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria Open
The prevalence of diabetes reaches epidemic proportions. Diabetes is the leading cause of end-stage kidney disease (ESKD) since 30–40% of diabetic patients develop diabetic nephropathy. Albuminuria and glomerular filtration rate used to as…
View article: Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria
Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria Open
View article: Advanced glycation end-products associate with podocytopathy in type II diabetic patients
Advanced glycation end-products associate with podocytopathy in type II diabetic patients Open
Background The prevalence of diabetes reaches epidemic proportions, affecting the incidence of diabetic nephropathy (DN) and associated end-stage kidney disease (ESKD). Diabetes is the leading cause of ESKD since 30–40% of diabetic patient…
View article: Growth hormone induces mitotic catastrophe of podocytes and contributes to proteinuria
Growth hormone induces mitotic catastrophe of podocytes and contributes to proteinuria Open
Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly differentiated cells are vulnerable to an array of noxious stimuli that prevail in se…
View article: Glomerulotubular Injury and Phenotypic Switch of Kidney Cells in Diabetic Nephropathy
Glomerulotubular Injury and Phenotypic Switch of Kidney Cells in Diabetic Nephropathy Open
The increased prevalence of diabetes mellitus (T2DM), and one of the complications, diabetic nephropathy (DN), constitutes a significant health care burden worldwide.Nephron, the kidney's structural and functional unit, includes two princi…
View article: Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria
Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria Open
Introduction Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiat…
View article: Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria
Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria Open
View article: Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy
Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy Open
Growth hormone (GH) plays a significant role in normal renal function and overactive GH signaling has been implicated in proteinuria in diabetes and acromegaly. Previous results have shown that the glomerular podocytes, which play an essen…
View article: Cerebral ischemia induces TRPC6 in the glomerular podocytes: A novel role for HIF1α/ZEB2 axis in the pathogenesis of stroke-induced proteinuria
Cerebral ischemia induces TRPC6 in the glomerular podocytes: A novel role for HIF1α/ZEB2 axis in the pathogenesis of stroke-induced proteinuria Open
Glomerular filtration apparatus (GFA) regulates the glomerular permselectivity and ultrafiltration of urine. Podocytes are specialized cells and a key component of the GFA. The mechanism by which the integrity of the GFA is compromised and…
View article: Growth Hormone and Metabolic Homeostasis
Growth Hormone and Metabolic Homeostasis Open
Pituitary growth hormone (GH) is a peptide hormone predominantly secreted by somatotrophs in the anterior pituitary under the tight control of the hypothalamic–pituitary axis and GH secretagogues. GH elicits its effects directly on target …
View article: Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria
Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria Open
The glomerular filtration barrier (GFB) plays a critical role in ensuing protein free urine. The integrity of the GFB is compromised during hypoxia that prevails during extreme physiological conditions. However, the mechanism by which glom…
View article: Novel Actions of Growth Hormone in Podocytes: Implications for Diabetic Nephropathy
Novel Actions of Growth Hormone in Podocytes: Implications for Diabetic Nephropathy Open
The kidney regulates water, electrolyte, and acid-base balance and thus maintains body homeostasis. The kidney's potential to ensure ultrafiltered and almost protein-free urine is compromised in various metabolic and hormonal disorders suc…
View article: Epithelial–mesenchymal Transition of Glomerular Podocytes: Implications in Proteinuria
Epithelial–mesenchymal Transition of Glomerular Podocytes: Implications in Proteinuria Open
View article: <i>In silico</i> Structural characterization of podocin and assessment of nephrotic syndrome‐associated podocin mutants
<i>In silico</i> Structural characterization of podocin and assessment of nephrotic syndrome‐associated podocin mutants Open
Nephrotic syndrome (NS) is manifested by hyperproteinuria, hypoalbuminemia, and edema. NPHS2 that encodes podocin was found to have most mutations among the genes that are involved in the pathophysiology of NS. Podocin, an integral membran…