Rajkumar Prabhakaran
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View article: NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation
NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation Open
The increasing global incidence of colorectal cancer (CRC) necessitates the development of innovative and targeted therapeutic interventions. Marine-derived bioactive compounds have gained prominence due to their structural diversity, intr…
View article: Investigating the colon toxicity and carcinogenic role of monosodium glutamate compared with Dimethylhydrazine in male Wistar rats: Exploring the link to childhood colon cancer risk
Investigating the colon toxicity and carcinogenic role of monosodium glutamate compared with Dimethylhydrazine in male Wistar rats: Exploring the link to childhood colon cancer risk Open
Background: Colon cancer is rising among younger population than elder people. About 50% of colon cancer cases attributed to dietary factors. Monosodium glutamate (MSG) widely used taste enhancer prevalent in fast foods and processed items…
View article: Synergistic effects of Rossellomorea marisflavi spp. DAS-SCF02 and Agrococcus spp. RKDAS1 as a probiotic functional feed (PFF) in Nile tilapia: Insights into growth, hemato-biochemical, and immune responses in the face of Vibrio challenges
Synergistic effects of Rossellomorea marisflavi spp. DAS-SCF02 and Agrococcus spp. RKDAS1 as a probiotic functional feed (PFF) in Nile tilapia: Insights into growth, hemato-biochemical, and immune responses in the face of Vibrio challenges Open
Probiotics offer significant health advantages as they enter the digestive system via diet or water intake, playing a crucial role in enhancing immunity, growth, gastrointestinal microbiota, and feed attribute. The main objective of study …
View article: Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy Open
Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefro…
View article: Development of a Simple, Low-Cost, Highly Specific Colorimetry-Based Whole-Cell Bacterial Biosensor for Cadmium Detection in the Environment
Development of a Simple, Low-Cost, Highly Specific Colorimetry-Based Whole-Cell Bacterial Biosensor for Cadmium Detection in the Environment Open
The urgent requirement for cost-effective technology to detect heavy metals in the environment is undeniable. This study introduces a novel approach: a low-cost colorimetry-based optical whole-cell bacterial biosensor utilizing a newly ide…
View article: Targeted therapy: Role of liposome-based drug delivery in advancing oral cancer treatment
Targeted therapy: Role of liposome-based drug delivery in advancing oral cancer treatment Open
View article: Advancements in targeted drug delivery: A promising approach in oral cancer treatment
Advancements in targeted drug delivery: A promising approach in oral cancer treatment Open
• Cancer may surpass cardiovascular disease as the top global killer, with OC as a concern. • Traditional treatments (surgery, chemo, radiation) have side effects and limited efficacy. • Targeted drug delivery uses nanotechnology to treat …
View article: Elucidation of the CadA Protein 3D Structure and Affinity for Metals
Elucidation of the CadA Protein 3D Structure and Affinity for Metals Open
The mitigation of cadmium (Cd) pollution, a significant ecological threat, is of paramount importance. Pseudomonas aeruginosa harbors 2 Cd resistance genes, namely, cadR and cadA. Presently, our focus is on the identification and character…
View article: Male Breast Cancer: Current Scenario and Future Perspectives
Male Breast Cancer: Current Scenario and Future Perspectives Open
Male breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%. Since the last 10 years, the incidence has been increased fro…
View article: Impact of THIONIL ® on reducing water and soil micropollutant and enhancement of growth, survival, antivibrio, immunity and health indices of Litopenaeus vannamei in pond trial
Impact of THIONIL ® on reducing water and soil micropollutant and enhancement of growth, survival, antivibrio, immunity and health indices of Litopenaeus vannamei in pond trial Open
There is an urgent requisite for an improvement of the white leg shrimp Litopenaeus vannamei health related indices and immunity due to the emerging diseases. Recently, probiotics have been playing an important role in L. vannamei health m…
View article: Non-canonical RNA dependent RNA polymerase (RdRp) activity of ORF8 protein in SARS-CoV-2: Equivocal biological significance
Non-canonical RNA dependent RNA polymerase (RdRp) activity of ORF8 protein in SARS-CoV-2: Equivocal biological significance Open
No current treatment options were successful in containing the ongoing pandemic COVID-19 caused by SARS-CoV-2. It is essential to understand the molecular players of SARS-CoV-2 to find a suitable treatment method and to develop an effectiv…
View article: Soil dynamics modulation of stress enzymes and secondary metabolites in allium cepa (L.) under salinity stress
Soil dynamics modulation of stress enzymes and secondary metabolites in allium cepa (L.) under salinity stress Open
In Allium cepa (L.) cultivation, salinity stress is the most important environmental factor worldwide that affects plant growth, protection as well as yield stability. The present study was carried out to examine the alterations in soil dy…
View article: Biochemical and molecular anticancer approaches for Boerhaavia diffusa root extracts in oral cancer
Biochemical and molecular anticancer approaches for Boerhaavia diffusa root extracts in oral cancer Open
Background: Boerhaavia diffusa is a medicinal herb with anti-inflammatory, antiproliferative, anticancer, and immunomodulatory properties, found across India. Aim and Objectives: The present study is designed to investigate the therapeutic…
View article: Neurons and mechanism of epileptic associated genes in brain network: current concepts and future perspectives
Neurons and mechanism of epileptic associated genes in brain network: current concepts and future perspectives Open
Neurons are the basic cell structure of the nervous system and responsible for the communication between brain and body. Brain networks are formed from a single neuron to highly complexed interconnected (˷ 100 billion) neurons. Imbalances …
View article: Exopolysaccharide production by optimized medium using novel marine Enterobacter cloacae MBB8 isolate and its antioxidant potential
Exopolysaccharide production by optimized medium using novel marine Enterobacter cloacae MBB8 isolate and its antioxidant potential Open
Exopolysaccharide (EPS) producing bacterial strains were isolated from the seawater of Gulf of Mannar region, Tamil Nadu. Using biochemical and molecular studies we identified the potent EPS producing bacterium as Enterobacter cloacae mari…
View article: ORF8 protein in SARS-CoV-2 might be a non-canonical RNA dependent RNA polymerase (RdRp)
ORF8 protein in SARS-CoV-2 might be a non-canonical RNA dependent RNA polymerase (RdRp) Open
No current treatment options were successful in containing the ongoing pandemic COVID-19 caused by SARS-CoV-2. It is essential to understand the molecular players of SARS-CoV-2 to find a suitable treatment method and to develop an effectiv…
View article: Theoretical designing of acetylcholine esterase (Ache) inhibitors
Theoretical designing of acetylcholine esterase (Ache) inhibitors Open
\n\tIn this manuscript, we have presented the results of binding efficacy of a range of chemical compounds that were generated from a modeled pharmacophore based upon structure clustering using donezaphil as a lead molecule. On analyzing …
View article: Oral administration of oxalate-enriched spinach extract as an improved methodology for the induction of dietary hyperoxaluric nephrocalcinosis in experimental rats
Oral administration of oxalate-enriched spinach extract as an improved methodology for the induction of dietary hyperoxaluric nephrocalcinosis in experimental rats Open
Experimental induction of hyperoxaluria by ethylene glycol (EG) administration is disapproved as it causes metabolic acidosis while the oral administration of chemically synthesized potassium oxalate (KOx) diet does not mimic our natural s…