Rajkumar V. Shete
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View article: Epilepsy: Insights into Pathophysiology, Therapeutic Approaches, and the Emerging Role of Phytochemicals
Epilepsy: Insights into Pathophysiology, Therapeutic Approaches, and the Emerging Role of Phytochemicals Open
The fourth most common cause of disease burden worldwide is epilepsy. A chronic neurological disorder marked by frequent, unprovoked seizures brought on by aberrant brain electrical activity. It affects more than 60 million people globally…
View article: Formulation, Development, and Evaluation of Novel Intranasal Drug Delivery Containing Sertraline Hydrochloride
Formulation, Development, and Evaluation of Novel Intranasal Drug Delivery Containing Sertraline Hydrochloride Open
The objective of this study was to formulate a niosomal in situ gel of sertraline hydrochloride for the treatment of depression. Sertraline hydrochloride is a Biopharmaceutical Classification System class II drug with low solubility and hi…
View article: DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TIGECYCLINE AND LINEZOLID IN BULK FORM.
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TIGECYCLINE AND LINEZOLID IN BULK FORM. Open
View article: Gall Stone Ileus and Recurrence: Management Dilemma for the Operating Surgeon
Gall Stone Ileus and Recurrence: Management Dilemma for the Operating Surgeon Open
View article: Bamboo Manna (Vanshalochan): A Review of Silica-Rich Panacea for Health and Wellness
Bamboo Manna (Vanshalochan): A Review of Silica-Rich Panacea for Health and Wellness Open
Bamboo manna, also known as vanshalochan, is a traditional herbal substance derived from bamboo plants, rich in silica and various minerals. This review explores its medicinal applications, focusing on its pharmacological properties and th…
View article: Formulation development and evaluation of floating microspheres of drotaverine hydrochloride as gastroretentive dosage form
Formulation development and evaluation of floating microspheres of drotaverine hydrochloride as gastroretentive dosage form Open
The aim of the current research work is to formulate and characterized the floating microspheres of drotaverine hydrochloride (DRH). DRH is an antispasmodic drug which has a short residence in the intestine during diarrhoea that prompts po…
View article: Evaluation of antiepileptic activity of ethanolic extract of garlic containing 3.25% allicin in experimental animals
Evaluation of antiepileptic activity of ethanolic extract of garlic containing 3.25% allicin in experimental animals Open
Introduction: Epilepsy is a condition of the brain that causes seizures and affects a significant portion of the global population, and current treatments often have limited efficacy and undesirable side effects. Throughout history, people…
View article: Allicin: A review of its important pharmacological activities
Allicin: A review of its important pharmacological activities Open
Background: Garlic (Allium sativum L.) is known for its synthesis of allicin, a defense molecule that exhibits various biological activities. Traditional medicine has utilized garlic to alleviate multiple ailments due to its broad spectrum…
View article: Enhancing the Solubility, Dissolution Rate and Oral Bioavailability of Poorly Water-soluble Drug, Satranidazole by Solid Dispersion prepared by using β-Cyclodextrin as a Carrier
Enhancing the Solubility, Dissolution Rate and Oral Bioavailability of Poorly Water-soluble Drug, Satranidazole by Solid Dispersion prepared by using β-Cyclodextrin as a Carrier Open
The present work aims to prepare and characterize solid dispersions of Santranidazole using β-Cyclodextrin to improve its aqueous solubility and dissolution with the aid of solvent evaporation technique. Solid dispersions showed marked imp…
View article: Silymarin, Quercetin and Hesperidin Combination Ameliorate Learning and Memory Deficit in 3 Nitro Propionic Acid Induced Rat Model of Huntington's Disease
Silymarin, Quercetin and Hesperidin Combination Ameliorate Learning and Memory Deficit in 3 Nitro Propionic Acid Induced Rat Model of Huntington's Disease Open
View article: Development and Characterization of Enclosed Prochlorperazine Maleate Floating Alginate Beads
Development and Characterization of Enclosed Prochlorperazine Maleate Floating Alginate Beads Open
The objective of present study aims to formulate enclosed floating alginate beads of Prochlorperazine Maleate (PCZM) for the treatment of nausea and vomiting. The Prochlorperazine Maleate which is having lower bioavailability up to 12.5% a…
View article: A review on phytochemical and pharmacological values of Aegle marmelos
A review on phytochemical and pharmacological values of Aegle marmelos Open
India is the largest producer of medicinal plants and is rightly referred to as "the World's Botanical Garden." Medicinal plants play a key role in the health and vitality of humans and animals alike. Researchers have been attempting to re…
View article: The Screening models for antiepileptic drugs: A Review
The Screening models for antiepileptic drugs: A Review Open
Considering the prevalence of epilepsy and the problems associated with currently available antiepileptic drugs like side effects, resistance, safety issue and high cost, herbal medicine with fewer complications could be very appropriate a…
View article: A Review on Pongamia pinnata (L.): Traditional Uses, Phytochemistry and Pharmacological Properties
A Review on Pongamia pinnata (L.): Traditional Uses, Phytochemistry and Pharmacological Properties Open
Pongamia pinnata (L.) Pierre is one of many plants with different medicinal properties where all its components have been used in the treatment and prevention of many forms of ailments in many countries as traditional medicine. The plant e…
View article: A Review on Gastro-Retentive Floating Microspheres
A Review on Gastro-Retentive Floating Microspheres Open
The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gas…
View article: Hydrodynamically Balanced System: A Review
Hydrodynamically Balanced System: A Review Open
The most suitable drug delivery route is oral delivery due to its easily administration, patient adherence/ patient capacitance etc. Several approaches have been made for maximizing the G.R.T such as high-density system, floating system, s…
View article: A Review on Microsphere
A Review on Microsphere Open
The microsphere is having free-flowing powder properties that are incorporate proteins and synthetic or natural polymer. This polymer is biodegradable in nature and particle size having less than 200 µm. Advanced drug delivery system has v…
View article: A Review on Solubility Enhancement by Solid Dispersion Method
A Review on Solubility Enhancement by Solid Dispersion Method Open
The issues of solubility for the targeted drug delivery of the new drug affects, the delivery many existing drug. The minimum 40% of the novel drug from the pharmaceutical industries are showing poor ability of solubilization in water. Hen…
View article: A review on Celastrus paniculatus wild (Jyotishmati): It’s species, geographical sources, phytoconstituents, and therapeutic uses and pharmacological actions
A review on Celastrus paniculatus wild (Jyotishmati): It’s species, geographical sources, phytoconstituents, and therapeutic uses and pharmacological actions Open
The Celastrus paniculatus wild belongs to family Celastraceae. In Ayurveda is known as ‘Tree of life’ and ‘Elixir of life’. The plant contains bioactive compound such as Alkaloids, Tannins, Flavonoids, Saponins, Steroids, Terpenoids, Phlob…
View article: A Review on Carissa carandas: Traditional Use, Phytochemical Constituents, and Pharmacological properties
A Review on Carissa carandas: Traditional Use, Phytochemical Constituents, and Pharmacological properties Open
Carissa carandas l. (Karaunda) is a widely useful food and medicinal plant of India, Plant-based medicines play an important role in all cultures have been indispensable in maintaining health and combating diseases. Owing to the global tre…
View article: Antidiabetic potential of Triphala Guggul - an ayurvedic formulation in alloxan-induced diabetes animal model
Antidiabetic potential of Triphala Guggul - an ayurvedic formulation in alloxan-induced diabetes animal model Open
The purpose of this study was to evaluate the potential antidiabetic drug Triphala guggul (TG), an indigenous polyherbal Ayurvedic formulation in an alloxan-induced diabetes rat model. Diabetes mellitus was induced in rats. The rats were d…
View article: Analytical Method Development and Validation for biotin from Premixes (solid blend of Multi-Vitamin) by RP-HPLC
Analytical Method Development and Validation for biotin from Premixes (solid blend of Multi-Vitamin) by RP-HPLC Open
To Develop and Validate Analytical method which is simple, rapid and sensitive for the determination of biotin from premixes (solid blend of multi-vitamin) by RP-HPLC. RP-HPLC analysis was performed using HPLC Agilent Technology 1260 Infin…
View article: Development and Evaluation of Pantoprazole Sodium Floating Gel
Development and Evaluation of Pantoprazole Sodium Floating Gel Open
View article: Formulation and Development of Enteric Coated Tablet for Parkinson's Disease
Formulation and Development of Enteric Coated Tablet for Parkinson's Disease Open
The current investigation is to formulate and develop enteric coated tablet of Ropinirole Hydrochloride. Enteric coated tablets were prepared by Wet Granulation method by using water as solvent. To protect drug from acid Eudragit L-100 was…
View article: Development and Characterization of Mesalamine Microsphere for Colon Specific Drug Delivery
Development and Characterization of Mesalamine Microsphere for Colon Specific Drug Delivery Open
View article: Stability Indicating RP-HPLC Method for Simultaneous Determination of Atorvastain and Nicotinic acid from Tablet Dosage Form
Stability Indicating RP-HPLC Method for Simultaneous Determination of Atorvastain and Nicotinic acid from Tablet Dosage Form Open
To develop simple, selective, specific, accurate and rapid Stability Indicating RP-HPLC method for simultaneous determination of Atorvastatin and nicotinic acid from tablet dosage form. The chromatographic separations of two lipid lowering…
View article: Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats
Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats Open
Previous studies proved the wound healing potential of Tilvadi Ghrita (TG) and Durva Ghrita (DG) on normal wounds, so this study was conducted to investigate wound healing activity of TG and DG on diabetic wound model in rats. Forty-eight …
View article: FORMULATION AND EVALUATION OF GLICLAZIDE NANOSPONGES
FORMULATION AND EVALUATION OF GLICLAZIDE NANOSPONGES Open
Objective: The objective of the present study was to develop and characterize an optimal stable nanosponges of Gliclazide (GLZ) by using the emulsion solvent diffusion method and aimed to increase its bioavailability and release the drug i…
View article: Traditional Remedies for Wound Healing: A Review
Traditional Remedies for Wound Healing: A Review Open
Wounds are a natural part of everyday life that can be successfully treated with the knowledge of Ayurveda. Ayurveda is the study of science that is based on herbal remedies. A wound must progress through vrana shodhana (wound purification…