Rajkumar Verma
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View article: Validation and Optimization of Breeding Strategy for miR-141/200c Knockout Mice to Eliminate Off-Target Gene Silencing using FLPo Deleter
Validation and Optimization of Breeding Strategy for miR-141/200c Knockout Mice to Eliminate Off-Target Gene Silencing using FLPo Deleter Open
MicroRNAs (miRNAs) of the miR-200 family specifically miR-141 and miR-200c regulate neurogenesis, differentiation, and epithelial–mesenchymal transitions in development and several diseases including cancer and stroke. The STOCK Mirc13 tm1…
View article: A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers
A comparative study between the efficacy of simple collagen dressing and antimicrobial-based collagen dressing in the treatment of diabetic and non-diabetic ulcers Open
Background: Chronic ulcers, especially diabetic foot ulcers, pose significant clinical challenges due to prolonged healing time, high infection rates, and increased health-care costs. Aims and Objectives: This study evaluates and compares …
View article: TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units
TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units Open
Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death. …
View article: Comparison of transanal Hemorrhoidopexy versus laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation
Comparison of transanal Hemorrhoidopexy versus laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation Open
Background: Hemorrhoids are a common proctological disease that affects the quality of life in the patient population to a great extent. Nearly 4.4–36% of population is affected by hemorrhoids. The symptoms of hemorrhoids vary from painles…
View article: Comparison of transanal Hemorrhoidopexy versus laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation
Comparison of transanal Hemorrhoidopexy versus laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation Open
Background: Hemorrhoids are a common proctological disease that affects the quality of life in the patient population to a great extent. Nearly 4.4–36% of population is affected by hemorrhoids. The symptoms of hemorrhoids vary from painles…
View article: Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery
Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery Open
View article: Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke
Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke Open
Background Purinergic receptor P2X4 (P2X4R), highly expressed on microglia and macrophages, is activated by ATP released from damaged cells and linked to poststroke inflammation. Previous studies showed that short‐term P2X4R inhibition red…
View article: Screening of Mungbean Germplasms against Root-Knot Nematode, Melodigyne javanica to Find Out the Source of Resistance
Screening of Mungbean Germplasms against Root-Knot Nematode, Melodigyne javanica to Find Out the Source of Resistance Open
Root-knot nematodes (Meloidogyne spp.) have been widely recorded in mung bean growing areas. Screening for resistant genotypes has reduced the damage caused by the root-knot nematodes. An experiment was conducted to find out the Screening …
View article: A comparative study between laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation and conventional (Milligan-Morgan) hemorrhoidectomy
A comparative study between laser hemorrhoidoplasty with digital-guided hemorrhoidal artery ligation and conventional (Milligan-Morgan) hemorrhoidectomy Open
Background: Hemorrhoids have a much higher incidence than rectum and colon diseases worldwide. The prevalence was estimated to be between 2.9% and 27.9% among the worldwide population, of which 4% are symptomatic. Based on the Gauss method…
View article: Comparison of three-port versus four-port laparoscopic cholecystectomy
Comparison of three-port versus four-port laparoscopic cholecystectomy Open
Background: In the era of laparoscopic surgery, early recovery and less post-operative pain are major goals to improve patient care and cut down cost. Several studies have demonstrated less post-operative pain and early recovery with the r…
View article: The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins
The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins Open
Implanted medical devices, from artificial heart valves and arthroscopic joints to implantable sensors, often induce a foreign body response (FBR), a form of chronic inflammation resulting from the inflammatory reaction to a persistent for…
View article: HYPOTHYROIDISM IN HEAD-AND-NECK CARCINOMA PATIENTS AFTER RADIATION
HYPOTHYROIDISM IN HEAD-AND-NECK CARCINOMA PATIENTS AFTER RADIATION Open
Objective: The objective of the study was to determine the incidence of clinical hypothyroidism in patients undergoing radiation therapy for head-and-neck carcinomas. Methods: One hundred and fifty patients with head-and-neck cancers visit…
View article: Comparative study of laser versus open lateral internal sphincterotomy in the treatment of anal fissure
Comparative study of laser versus open lateral internal sphincterotomy in the treatment of anal fissure Open
Background: Anal fissure is a common proctological problem that causes anal pain during and after defecation. An anal fissure is a linear ulcer that presents at the anal verge. It is more common in females than males and can be seen either…
View article: The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins
The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins Open
Implanted medical devices from artificial heart valves, arthroscopic joints to implantable sensors often induce a Foreign Body Response (FBR), a form of chronic inflammation resulting from the inflammatory reaction to a persistent foreign …
View article: Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke Open
View article: Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4R KO mice after ischemic stroke
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4R KO mice after ischemic stroke Open
Identification of new potential drug target proteins and their plausible mechanisms for stroke treatment is critically needed. We previously showed that genetic deletion and short-term pharmacological inhibition of P2X4R, a purinergic rece…
View article: Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy
Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy Open
Ischemic Stroke causes acute CNS disorders. This article represents an injectable liposomal nanoparticle formulation of 5-BDBD and Nile red for treatment of Ischemic Stroke.
View article: Structure–Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2<i>H</i>-naphtho[1,2-<i>b</i>][1,4]diazepine-2,4(3<i>H</i>)-diones as P2X4 Receptor Antagonists
Structure–Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2<i>H</i>-naphtho[1,2-<i>b</i>][1,4]diazepine-2,4(3<i>H</i>)-diones as P2X4 Receptor Antagonists Open
We analyzed the P2X4 receptor structure-activity relationship of a known antagonist 5, a 1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione. Following extensive modification of the reported synthetic rout…
View article: A Novel Model for Encephalomyosynangiosis Surgery after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
A Novel Model for Encephalomyosynangiosis Surgery after Middle Cerebral Artery Occlusion-Induced Stroke in Mice Open
Background and Purpose No effective treatment is available for most patients who suffer ischemic stroke. Development of novel treatment options is imperative. The brain attempts to self-heal after ischemic stroke via various mechanism medi…
View article: Nanoparticle Delivered Anti-miR-141-3p for Stroke Therapy
Nanoparticle Delivered Anti-miR-141-3p for Stroke Therapy Open
Ischemic stroke and factors modifying ischemic stroke responses, such as social isolation, contribute to long-term disability worldwide. Several studies demonstrated that the aberrant levels of microRNAs contribute to ischemic stroke injur…
View article: Immobilizing the jaw during stereotactic radiosurgery for lesions extending beyond temporomandibular joint: An avant-garde approach for a quick, reversible, non-invasive, radiolucent and reliable fixation.
Immobilizing the jaw during stereotactic radiosurgery for lesions extending beyond temporomandibular joint: An avant-garde approach for a quick, reversible, non-invasive, radiolucent and reliable fixation. Open
View article: Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery
Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery Open
Low levels of brain-derived neurotrophic factor (BDNF) are linked to delayed neurological recovery, depression, and cognitive impairment following stroke. Supplementation with BDNF reverses these effects. Unfortunately, systemically admini…
View article: Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke
Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke Open
View article: EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke
EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke Open
Acute inhibition of CD147 decreases levels of MMP-9, limits tissue loss, and improves long-term cognitive outcomes following experimental stroke in aged mice. High serum CD147 correlates with poor outcomes in stroke patients. This study id…
View article: Micro RNA 181c-5p: A promising target for post-stroke recovery in socially isolated mice
Micro RNA 181c-5p: A promising target for post-stroke recovery in socially isolated mice Open
View article: CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke
CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke Open
View article: Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice
Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice Open
Background and Purpose— Social isolation increases mortality and impairs recovery after stroke in clinical populations. These detrimental effects have been recapitulated in animal models, although the exact mechanism mediating these effect…
View article: Aging alters the immunological response to ischemic stroke
Aging alters the immunological response to ischemic stroke Open
View article: INTESTINAL OBSTRUCTION IN PAEDIATRIC AGE GROUP DUE TO FOREIGN BODY INGESTION
INTESTINAL OBSTRUCTION IN PAEDIATRIC AGE GROUP DUE TO FOREIGN BODY INGESTION Open
An eight-year-old girl presented with chief complaints of abdominal pain associated with abdominal distension and paucity of faeces and flatus for four days.Pain was colicky in nature, mostly involving lower part of the abdomen.Patient gav…
View article: Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke
Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke Open