Rajnish Kumar Singh
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View article: IN SILICO DRUG-RECEPTOR INTERACTION STUDY OF ARYL SULPHONAMIDE DERIVATIVES AS 5-HT6 SEROTONIN LIGAND USING INTERACTION ENERGY PARAMETER
IN SILICO DRUG-RECEPTOR INTERACTION STUDY OF ARYL SULPHONAMIDE DERIVATIVES AS 5-HT6 SEROTONIN LIGAND USING INTERACTION ENERGY PARAMETER Open
View article: Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection
Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection Open
Oncogenic gamma herpesviruses, including Epstein–Barr Virus (EBV) and Kaposi’s Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses and induces oncogenesis through complex mechanisms, which involves manipulation …
View article: Socio-Economic development of Tribal Women through Education
Socio-Economic development of Tribal Women through Education Open
Education is the only medium to empower women with knowledge, self-confidence, and their skills. This is necessary to them, participating fully in the extension process of the society. Education is the opening step to higher productivity, …
View article: Hypoxic reactivation of Kaposi's sarcoma associated herpesvirus
Hypoxic reactivation of Kaposi's sarcoma associated herpesvirus Open
View article: The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6
The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6 Open
Most mature B-cell malignancies originate from the malignant transformation of germinal center (GC) B cells. The GC reaction appears to have a role in malignant transformation, in which a major player of the GC reaction is BCL6, a key regu…
View article: Quantum mechanical parameters-based study of aryl sulphonamides as 5-HT6 serotonin ligand using DFT methods
Quantum mechanical parameters-based study of aryl sulphonamides as 5-HT6 serotonin ligand using DFT methods Open
In the present work, quantum mechanical descriptors have been used for the development of quantitative structure activity relationship (QSAR) models for the thirty-two derivatives of aryl sulphonamide and sulfone based 5-HT6 antagonists. A…
View article: KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia
KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia Open
Hypoxia results from an insufficient supply of oxygen, which results in physiological stress in biological systems. Cells respond to this unfavorable condition by reducing critical cellular functions, which include replication, transcripti…
View article: Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus
Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus Open
Epigenetic reprogramming represents a series of essential events during many cellular processes including oncogenesis. The genome of Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic herpesvirus, is predetermined for a well-orch…
View article: A Case Report on Catastrophic Antiphospholipid Syndrome with Cardiomyopathy
A Case Report on Catastrophic Antiphospholipid Syndrome with Cardiomyopathy Open
Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening disease that causes the formation of microthrombi in multiple vascular beds, leading to multiorgan dysfunction. We report an unusual case of systemic lupus erythematosus-a…
View article: Renal, splenic, and mesenteric artery thrombosis in the setting of cytomegalovirus infection of an immunocompromised patient: a case report
Renal, splenic, and mesenteric artery thrombosis in the setting of cytomegalovirus infection of an immunocompromised patient: a case report Open
We present a case report of an immunocompromised adult with cytomegalovirus infection and APLA positivity complicated by multiple large arterial thrombi. This is a rare presentation as most of the cases reported earlier have been of venous…
View article: Targeting Kaposi’s sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases
Targeting Kaposi’s sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases Open
Kaposi’s sarcoma associated herpesvirus (KSHV) is causative agent of Kaposi’s sarcoma, Multicentric Castleman Disease and Pleural effusion lymphoma. KSHV-encoded ORF17 encodes a protease which cleaves -Ala-Ala-, -Ala-Ser- or -Ala-Thr-bonds…
View article: Recurrence of disease in a patient with Covid-19: Re-activation or re-infection?
Recurrence of disease in a patient with Covid-19: Re-activation or re-infection? Open
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) was expected to induce a monophasic disease with subsequent immunity. However, case reports have since emerged which have found patients with either re-infection or re-activation …
View article: Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation
Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation Open
The biphasic life cycle (latent and lytic) of Kaposi’s sarcoma-associated Herpesvirus (KSHV) is regulated by epigenetic modification of its genome and its associated histone proteins. The temporal events driving epigenetic reprogramming of…
View article: HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability
HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability Open
View article: Selection and Precis(e) Varietal Recommender System
Selection and Precis(e) Varietal Recommender System Open
A field experiment in a randomized block design was conducted during Rabi season 2019-2020 on 13 wheat varieties with the twin objectives of objectively selecting and precisely recommending the suitable plant types to farmers of Deoria dis…
View article: KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia
KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia Open
The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associa…
View article: Author response: KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia
Author response: KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia Open
View article: HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus
HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus Open
Hypoxia is a detrimental stress to eukaryotes and inhibits several cellular processes, such as DNA replication, transcription, translation, and metabolism. Interestingly, the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV) is know…
View article: Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells
Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells Open
Dysbiotic microbiomes are linked to many pathological outcomes including different metabolic disorders like diabetes, atherosclerosis and even cancer. Breast cancer is the second leading cause of cancer associated death in women, and tripl…
View article: KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia
KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia Open
The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associa…
View article: Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform
Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform Open
View article: Correction: Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host.
Correction: Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host. Open
VOLUME 284 (2009) PAGES 27467–27479 During preparation of the figures for the manuscript, a portion of the silver-stained gel in Fig. 4B was erroneously incorporated into Fig. 1B. This error has now been corrected from a replicate experime…
View article: KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation
KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation Open
Kaposi's sarcoma associated herpesvirus (KSHV), like all herpesviruses maintains lifelong persistence with its host genome in latently infected cells with only a small fraction of cells showing signatures of productive lytic replication. M…
View article: EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis Open
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have…
View article: Correction: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
Correction: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy Open
[This corrects the article DOI: 10.1371/journal.ppat.1007253.].
View article: EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation
EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation Open
EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras asso…
View article: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy Open
Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number…
View article: Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2
Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2 Open
Epstein-Barr virus (EBV) is the first identified human tumor virus and is associated with a range of human cancers. During EBV-induced lymphomas, the essential viral latent proteins modify the expression of cell cycle-related proteins to d…
View article: Metabolic reprogramming of Kaposi’s sarcoma associated herpes virus infected B-cells in hypoxia
Metabolic reprogramming of Kaposi’s sarcoma associated herpes virus infected B-cells in hypoxia Open
Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotyp…
View article: Peer Observation: Improvement of Teaching Effectiveness through Class Participation at a Polytechnic University
Peer Observation: Improvement of Teaching Effectiveness through Class Participation at a Polytechnic University Open
A major goal of peer observation in the classroom is to provide instructors with formative feedback that will improve teaching effectiveness and enhance student learning. Peer observation in higher education has both quality and developme…