Raju C. Reddy
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View article: Impact of Balanced Crystalloids vs Saline by Resuscitation Strategy in Sepsis A Secondary Analysis of the Crystalloid Liberal or Vasopressor Early Resuscitation in Sepsis Trial
Impact of Balanced Crystalloids vs Saline by Resuscitation Strategy in Sepsis A Secondary Analysis of the Crystalloid Liberal or Vasopressor Early Resuscitation in Sepsis Trial Open
View article: A study to assess the knowledge and expected outcome on guidelines directed to medical therapy in heart failure patient undergoing treatment in IP and OP basis at Apollo DRDO hospitals, Hyderabad
A study to assess the knowledge and expected outcome on guidelines directed to medical therapy in heart failure patient undergoing treatment in IP and OP basis at Apollo DRDO hospitals, Hyderabad Open
Heart failure is a complex clinical condition. Optimal use of guideline-directed medical therapy (GDMT) can prevent hospitalization and mortality among patients with heart failure (HF). Although the guidelines-directed medical therapy for …
View article: Comprehensive characterization of a novel small-molecule activator for the nuclear receptor Nur77: Chemical, molecular, and biological insights
Comprehensive characterization of a novel small-molecule activator for the nuclear receptor Nur77: Chemical, molecular, and biological insights Open
The nuclear receptor Nur77 is a transcription factor belonging to the NR4A subfamily. Upon activation, it regulates a wide array of biological and pathophysiological processes by modulating the expression of its target genes. Previous find…
View article: Impact of Virtual Interviews on Pulmonary and Critical Care Fellowship Match: An Analysis of National Data
Impact of Virtual Interviews on Pulmonary and Critical Care Fellowship Match: An Analysis of National Data Open
Our study provides evidence regarding the effect of the virtual interview format on PCCM match results. Strikingly, applicants are more likely to match at lower-ranked programs in their rank list after the implementation of the virtual int…
View article: Effect of Obesity on Mortality in Pulmonary Hypertension—A Systematic Review and Meta-Analysis
Effect of Obesity on Mortality in Pulmonary Hypertension—A Systematic Review and Meta-Analysis Open
Obesity is reported to have a protective effect on mortality in pulmonary hypertension (PH), a phenomenon known as obesity paradox. However, the data are conflicting, with some studies showing decreased mortality while other studies found …
View article: Ascertainment of vaccination status by self‐report versus source documentation: Impact on measuring COVID‐19 vaccine effectiveness
Ascertainment of vaccination status by self‐report versus source documentation: Impact on measuring COVID‐19 vaccine effectiveness Open
Background During the COVID‐19 pandemic, self‐reported COVID‐19 vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available.…
View article: A Rare Case of Isolated Large Vessel Pulmonary Vasculitis
A Rare Case of Isolated Large Vessel Pulmonary Vasculitis Open
Isolated large vessel pulmonary vasculitis can present as isolated pulmonary artery stenosis with an absence of typical systemic vasculitis manifestations which can make diagnosis and treatment a challenge.A 16-year-old female athlete with…
View article: MASSIVE AIR EMBOLISM
MASSIVE AIR EMBOLISM Open
View article: Prevalence of Echocardiographic Pulmonary Hypertension in Patients Using Selective Serotonin and Selective Serotonin/Norepinephrine Reuptake Inhibitors
Prevalence of Echocardiographic Pulmonary Hypertension in Patients Using Selective Serotonin and Selective Serotonin/Norepinephrine Reuptake Inhibitors Open
View article: Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)
Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD) Open
Cigarette smoke (CS) contains multiple gaseous and particulate materials that can cause lung inflammation, and smoking is the major cause of chronic obstructive pulmonary disease (COPD). We sought to determine the mechanisms of how CS trig…
View article: <p>Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD</p>
Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD Open
Our findings highlight the significance of roflumilast-induced GRα upregulation for COPD therapeutic strategies by revealing that roflumilast restores glucocorticoid sensitivity by sustaining GRα expression.
View article: Table of Contents
Table of Contents Open
View article: Retraction: Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).
Retraction: Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD). Open
Down-regulated Peroxisome Proliferator-activated Receptor γ (PPARγ) in Lung Epithelial Cells Promotes a PPARγ Agonist-reversible Proinflammatory Phenotype in Chronic Obstructive Pulmonary Disease (COPD)Journal of Biological ChemistryVol. 2…
View article: Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases
Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases Open
View article: Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>
Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> Open
PPARδ belongs to the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors. Upon activation by an agonist, PPARδ controls a variety of physiological processes via regulation of its target genes. 15-Deoxy-Δ12,14…
View article: Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress Open
View article: Airway Epithelial Cell Peroxisome Proliferator–Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease
Airway Epithelial Cell Peroxisome Proliferator–Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease Open
Airway epithelial cells (AECs) orchestrate inflammatory responses to airborne irritants that enter the respiratory system. A viscous mucus layer produced by goblet cells in the airway epithelium also contributes to a physiological defense …
View article: PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma
PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma Open
Asthma affects approximately 300 million people worldwide, significantly impacting quality of life and healthcare costs. While current therapies are effective in controlling many patients' symptoms, a large number continue to experience ex…
View article: Emerging pharmaceutical therapies for COPD
Emerging pharmaceutical therapies for COPD Open
COPD, for which cigarette smoking is the major risk factor, remains a worldwide burden. Current therapies provide only limited short-term benefit and fail to halt progression. A variety of potential therapeutic targets are currently being …
View article: Transforming growth factor β suppresses peroxisome proliferator-activated receptor γ expression via both SMAD binding and novel TGF-β inhibitory elements
Transforming growth factor β suppresses peroxisome proliferator-activated receptor γ expression via both SMAD binding and novel TGF-β inhibitory elements Open
Transforming growth factor β (TGF-β) contributes to wound healing and, when dysregulated, to pathological fibrosis. TGF-β and the anti-fibrotic nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) repress each othe…
View article: PPAR Agonists for the Prevention and Treatment of Lung Cancer
PPAR Agonists for the Prevention and Treatment of Lung Cancer Open
Lung cancer is the most common and most fatal of all malignancies worldwide. Furthermore, with more than half of all lung cancer patients presenting with distant metastases at the time of initial diagnosis, the overall prognosis for the di…
View article: Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation
Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation Open
Nitrated fatty acids (NFAs), endogenous products of nonenzymatic reactions of NO-derived reactive nitrogen species with unsaturated fatty acids, exhibit substantial anti-inflammatory activities. They are both reversible electrophiles and p…
View article: PPAR<i>γ</i>in Bacterial Infections: A Friend or Foe?
PPAR<i>γ</i>in Bacterial Infections: A Friend or Foe? Open
Peroxisome proliferator-activated receptor γ (PPAR γ ) is now recognized as an important modulator of leukocyte inflammatory responses and function. Its immunoregulatory function has been studied in a variety of contexts, including bacteri…
View article: PPAR<i>γ</i>as a Novel Therapeutic Target in Lung Cancer
PPAR<i>γ</i>as a Novel Therapeutic Target in Lung Cancer Open
Lung cancer is the leading cause of cancer-related death, with more than half the patients having advanced-stage disease at the time of initial diagnosis and thus facing a poor prognosis. This dire situation poses a need for new approaches…