Raju Doddipalla
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View article: Isolation and Characterization of Anticancer Properties of Compounds from the Leaf Extracts of Vitex negundo
Isolation and Characterization of Anticancer Properties of Compounds from the Leaf Extracts of Vitex negundo Open
Vitex negundo belongs to the family of Lamiaceae and is popularly known as sambhaloo or Chinese chaste tree. It is widely used as Indian medicinal shrub to prevent a variety of ailments including cancer. The aim of the study was to investi…
View article: Force degradation studies of relugolix: identification, isolation and structure characterization of stress degradation products by using liquid chromatography-mass spectrometry, auto purification mass mediated preparative-high performance liquid chromatography, high resolution mass spectrometry, nuclear magnetic resonance spectroscopy
Force degradation studies of relugolix: identification, isolation and structure characterization of stress degradation products by using liquid chromatography-mass spectrometry, auto purification mass mediated preparative-high performance liquid chromatography, high resolution mass spectrometry, nuclear magnetic resonance spectroscopy Open
To assess the stability of Relugolix under stress conditions, identify and characterize the degradation products, it was subjected to hydrolytic and oxidative stress conditions, according to the International Council for Harmonization guid…
View article: STRUCTURE CHARACTERIZATION OF STRESS DEGRADATION PRODUCTS OF ELAGOLIX BY USING HRMS, NMR
STRUCTURE CHARACTERIZATION OF STRESS DEGRADATION PRODUCTS OF ELAGOLIX BY USING HRMS, NMR Open
Elagolix Sodium is a recently approved drug used to treat endometriosis in women. Elagolix sodium was exposed to forced degradation (acid, base, neutral, oxidative, thermal, and photolytic) as per International Council for Harmonisation gu…
View article: Understanding metabolic perturbations in palm wine during storage using multi-platform metabolomics
Understanding metabolic perturbations in palm wine during storage using multi-platform metabolomics Open
The metabolic perturbations in palm wine under five (0, 12, 24, 48, 72 h) storage intervals was studied using NMR and LC-HRMS. From 100 (25 from NMR and 75 from LC-HRMS) identified metabolites, 9 and 10 from NMR and LC- HRMS were identifie…
View article: Degradation Studies of Tadalafil: Identification, Isolation and Structure Characterization ofStress Degradation Product using LC-MS, Mass Mediated Prep-HPLC, NMR, HRMS
Degradation Studies of Tadalafil: Identification, Isolation and Structure Characterization ofStress Degradation Product using LC-MS, Mass Mediated Prep-HPLC, NMR, HRMS Open
The degradation behaviour of tadalafil performed under different stress conditions according to International Conference on Harmonization guidelines (ICH) was studied. A novel degradation product (DP) of tadalafil was observed only in acid…
View article: Degradation Studies of Lacidipine: Identification, Isolation and Structural Characterizationof Stress Degradation Products using LCMS, Mass mediated Prep-HPLC, NMR and HRMS
Degradation Studies of Lacidipine: Identification, Isolation and Structural Characterizationof Stress Degradation Products using LCMS, Mass mediated Prep-HPLC, NMR and HRMS Open
The stability of lacidipine drug under stress conditions and the identification of the degradation products, according to ICH guidelines Q1A (R2) were investigated in the hydrolytic and oxidative stress conditions. The drug degradation occ…
View article: Hydrolytic Degradation Study of Rivaroxaban: Degradant Products Identification byLC-MS Isolation by Prep-HPLC and Characterization by HRMS, NMR and FT-IR
Hydrolytic Degradation Study of Rivaroxaban: Degradant Products Identification byLC-MS Isolation by Prep-HPLC and Characterization by HRMS, NMR and FT-IR Open
Present work illustrates the stress degradation behaviour of rivaroxaban under hydrolytic, oxidative, thermal and photolytic conditions as per ICH guidelines. Under thermal and photolytic conditions drug had a fair stability where as in ot…
View article: Degradation studies of levosimendan isolation, identification, and structure confirmation of stress degradation products using LCMS, mass mediated Prep-HPLC, NMR, HRMS, SFC and FTIR
Degradation studies of levosimendan isolation, identification, and structure confirmation of stress degradation products using LCMS, mass mediated Prep-HPLC, NMR, HRMS, SFC and FTIR Open
The present work describes the stress degradation behavior of Levosimendan as per ICH guidelines. Under thermal and photolytic conditions drug had a fair stability and in other stress conditions degradation products (DP) were observed. Ini…
View article: Isolation, identification and characterization of new degradation products of Carfilzomib using high resolution mass spectrometry and nuclear magnetic resonance
Isolation, identification and characterization of new degradation products of Carfilzomib using high resolution mass spectrometry and nuclear magnetic resonance Open
View article: CCDC 1812840: Experimental Crystal Structure Determination
CCDC 1812840: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1812841: Experimental Crystal Structure Determination
CCDC 1812841: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …