Raju R. Raval
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View article: NCOG-16. Effect of Early Integrated Neuropsychological Care in Patients with Brain Metastases – A Phase 2 Randomized Controlled Trial (ATHENA Trial)
NCOG-16. Effect of Early Integrated Neuropsychological Care in Patients with Brain Metastases – A Phase 2 Randomized Controlled Trial (ATHENA Trial) Open
Radiation advancements including hippocampal avoidance whole brain radiotherapy (HA-WBRT) and stereotactic radiosurgery (SRS) can better preserve quality-of-life (QOL) and mitigate the risk of cognitive decline, but many patients experienc…
View article: Dr. Bharat H. Shah (19-11-1933 to 14-5-2025)
Dr. Bharat H. Shah (19-11-1933 to 14-5-2025) Open
View article: Multimodal Nuclear Imaging Response as a Prognostic Indicator Following Spine Stereotactic Body Radiotherapy
Multimodal Nuclear Imaging Response as a Prognostic Indicator Following Spine Stereotactic Body Radiotherapy Open
View article: Effect of Early Integrated Neuropsychological Care in Patients with Brain Metastases: A Phase 2 Randomized Controlled Trial (ATHENA Trial)
Effect of Early Integrated Neuropsychological Care in Patients with Brain Metastases: A Phase 2 Randomized Controlled Trial (ATHENA Trial) Open
View article: Descriptive Analysis of Breast Cancer Patients with Brain-Only Metastases Using the National Cancer Database
Descriptive Analysis of Breast Cancer Patients with Brain-Only Metastases Using the National Cancer Database Open
View article: RDTA-06 AN INITIAL REPORT OF MEMORY AVOIDANCE WHOLE BRAIN RADIOTHERAPY TO TREAT BRAIN METASTASES: A PROSPECTIVE PHASE 2 TRIAL
RDTA-06 AN INITIAL REPORT OF MEMORY AVOIDANCE WHOLE BRAIN RADIOTHERAPY TO TREAT BRAIN METASTASES: A PROSPECTIVE PHASE 2 TRIAL Open
A common approach for patients with extensive brain metastases requiring radiation is hippocampal avoidance whole brain radiotherapy (HA-WBRT) prescribed with memantine; this was proven reduce the incidence of cognitive decline in NRG CC00…
View article: CTLT-02 EFFECT OF EARLY INTEGRATED NEUROPSYCHOLOGICAL CARE IN PATIENTS WITH BRAIN METASTASES – A PHASE 2 RANDOMIZED CONTROLLED TRIAL (ATHENA TRIAL)
CTLT-02 EFFECT OF EARLY INTEGRATED NEUROPSYCHOLOGICAL CARE IN PATIENTS WITH BRAIN METASTASES – A PHASE 2 RANDOMIZED CONTROLLED TRIAL (ATHENA TRIAL) Open
Radiation advancements including hippocampal avoidance whole brain radiotherapy (HA-WBRT) and stereotactic radiosurgery (SRS) can better preserve quality-of-life (QOL) and mitigate the risk of cognitive decline, but many patients experienc…
View article: Remarkable Resolution of Radiation Necrosis Post-Obsessive-Compulsive Disorder Radiosurgery With Boswellia Serrata: Case Report
Remarkable Resolution of Radiation Necrosis Post-Obsessive-Compulsive Disorder Radiosurgery With Boswellia Serrata: Case Report Open
View article: Brief Report: Central Nervous System Metastases After Chemoradiation Followed by Durvalumab for Unresectable Locally Advanced Nonsmall Cell Lung Cancer
Brief Report: Central Nervous System Metastases After Chemoradiation Followed by Durvalumab for Unresectable Locally Advanced Nonsmall Cell Lung Cancer Open
View article: Stereotactic Radiosurgery for a Patient With 94 Brain Metastases in the Setting of Prior Whole Brain Radiation
Stereotactic Radiosurgery for a Patient With 94 Brain Metastases in the Setting of Prior Whole Brain Radiation Open
The current standard of care treatment for patients with ≥15 brain metastases (BM) is whole brain radiation therapy (WBRT), despite poor neurocognitive outcomes. Here, we present our experience treating a young patient with 94 intact brain…
View article: Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk
Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk Open
In this expanded pooled analysis, consistent with previously published findings, EP disruption, adverse pathology, and higher SINS scores were associated with an increased risk of VCF. Additionally, we found that chronic steroid use for fo…
View article: Expanded Analysis of Vertebral Endplate Disruption and Its Impact on Vertebral Compression Fracture Risk
Expanded Analysis of Vertebral Endplate Disruption and Its Impact on Vertebral Compression Fracture Risk Open
Background and Objectives: Vertebral compression fracture (VCF) is a potential serious complication of spinal stereotactic body radiotherapy (SBRT). Previously we noted a correlation between advanced Spinal Instability Neoplastic Score (SI…
View article: Boswellia Serrata for Cerebral Radiation Necrosis After Radiosurgery for Brain Metastases
Boswellia Serrata for Cerebral Radiation Necrosis After Radiosurgery for Brain Metastases Open
Our study suggests that BS is a safe and feasible treatment option for grade 1 to 3 RN after SRS. Further prospective studies comparing BS with a placebo are warranted.
View article: Emotion-Driven Text Generation: A Framework for Personalized Narrative Construction
Emotion-Driven Text Generation: A Framework for Personalized Narrative Construction Open
View article: Adaptive Context-Aware Language Models for Code-Mixed Multilingual Conversations
Adaptive Context-Aware Language Models for Code-Mixed Multilingual Conversations Open
View article: Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas
Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas Open
Background Our previous clinical investigation suggested that hypofractionated stereotactic re-irradiation (HFSRT) and PD-1 blockade may act synergistically to enhance the immune response against glioma. This subsequent trial investigated …
View article: Correction to: Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium
Correction to: Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium Open
View article: Delayed and Concurrent Stereotactic Radiosurgery in Immunotherapy-Naïve Melanoma Brain Metastases
Delayed and Concurrent Stereotactic Radiosurgery in Immunotherapy-Naïve Melanoma Brain Metastases Open
Melanoma remains a formidable challenge in oncology, causing the majority of skin cancer deaths in the United States, with brain metastases contributing substantially to this mortality. This paper reviews the current therapeutic strategies…
View article: Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells
Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells Open
Andrographolide, a natural product, putatively functions through covalent inhibition of NF-κB, a transcription factor that modulates tumor survival and metastasis. Previous studies found that functionalization of the C-19 hydroxyl alters t…
View article: Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium
Impact of instrumentation material on local recurrence: a case-matched series using carbon fiber-PEEK vs. titanium Open
Purpose Spine metastases are a major burden of oncologic care, contributing to substantial morbidity. A well-established treatment paradigm for patients with metastatic epidural spinal cord compression includes separation surgery followed …
View article: “Intrasellar tumor-to-tumor metastasis: A single center experience with a systematic review”
“Intrasellar tumor-to-tumor metastasis: A single center experience with a systematic review” Open
View article: RADT-02 PRE-OPERATIVE VERSUS POST-OPERATIVE FRACTIONATED STEREOTACTIC RADIOTHERAPY: A SINGLE-INSTITUTION ANALYSIS OF 534 RESECTED METASTASES
RADT-02 PRE-OPERATIVE VERSUS POST-OPERATIVE FRACTIONATED STEREOTACTIC RADIOTHERAPY: A SINGLE-INSTITUTION ANALYSIS OF 534 RESECTED METASTASES Open
Patients with large or symptomatic brain metastases and limited intracranial disease typically have surgery followed by post-operative (post-op) stereotactic radiosurgery (SRS). However, SRS can lead to elevated rates of radiation necrosis…
View article: RADT-03 PRE-OPERATIVE SINGLE FRACTION VERSUS FRACTIONATED STEREOTACTIC RADIOTHERAPY: A SINGLE-INSTITUTION ANALYSIS OF 299 RESECTED METASTASES
RADT-03 PRE-OPERATIVE SINGLE FRACTION VERSUS FRACTIONATED STEREOTACTIC RADIOTHERAPY: A SINGLE-INSTITUTION ANALYSIS OF 299 RESECTED METASTASES Open
The treatment standard for patients with large or symptomatic brain metastases and limited intracranial disease is surgical resection followed by post-operative (post-op) stereotactic radiosurgery (SRS). The multicenter PROPS-BM cohort sho…
View article: Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy for Recurrent and/or Metastatic Cancers in Young-Adult and Pediatric Patients
Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy for Recurrent and/or Metastatic Cancers in Young-Adult and Pediatric Patients Open
Background: Pediatric patients with metastatic and/or recurrent solid tumors have poor survival outcomes despite standard-of-care systemic therapy. Stereotactic ablative radiation therapy (SABR) may improve tumor control. We report the out…
View article: Safety and Feasibility of Stereotactic Radiosurgery for Patients with 15 or more Brain Metastases
Safety and Feasibility of Stereotactic Radiosurgery for Patients with 15 or more Brain Metastases Open
We present here one of the largest studies evaluating SRS for patients with ≥15 BMs. SRS was safe, had favorable cognitive outcomes, and had comparable survival outcomes to contemporary studies evaluating WBRT in this population. Treatment…
View article: Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy (LITE-SABR) for Recurrent and/or Metastatic Pediatric Cancers
Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy (LITE-SABR) for Recurrent and/or Metastatic Pediatric Cancers Open
View article: Stereotactic Radiosurgery for Women Older than 65 with Breast Cancer Brain Metastases
Stereotactic Radiosurgery for Women Older than 65 with Breast Cancer Brain Metastases Open
Background: Breast cancer is the second most common cause of brain metastases (BM). Despite increasing incidence of BM in older women, there are limited data on the optimal management of BM in this age group. In this study, we assessed the…
View article: Volumetric Modulated Arc Therapy Craniospinal Irradiation Utilizing a Vertebral Body Sparing Approach: An Alternative Approach to Improve Access and Minimize Toxicity
Volumetric Modulated Arc Therapy Craniospinal Irradiation Utilizing a Vertebral Body Sparing Approach: An Alternative Approach to Improve Access and Minimize Toxicity Open
In this study, VMAT VBS CSI led to acceptable toxicity compared with patients treated with proton CSI on a phase 2 clinical trial. Given its promising early results, future prospective evaluation of the technique is warranted.
View article: Glioblastoma pseudoprogression and true progression reveal spatially variable transcriptional differences
Glioblastoma pseudoprogression and true progression reveal spatially variable transcriptional differences Open
View article: RADT-20. STEREOTACTIC RADIOSURGERY FOR 15 OR MORE BRAIN METASTASES
RADT-20. STEREOTACTIC RADIOSURGERY FOR 15 OR MORE BRAIN METASTASES Open
BACKGROUND Patients with ≥ 15 brain metastases(BM) continue to be treated with whole brain radiation therapy(WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience of treating these patients with stereotactic…