Rakchha Chhetri
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View article: Substantially improved survival for intermediate-risk AML: an Australian statewide network experience spanning 20 years
Substantially improved survival for intermediate-risk AML: an Australian statewide network experience spanning 20 years Open
View article: Generative AI chatbots for reliable cancer information: Evaluating web-search, multilingual, and reference capabilities of emerging large language models
Generative AI chatbots for reliable cancer information: Evaluating web-search, multilingual, and reference capabilities of emerging large language models Open
Recent advancements in large language models (LLMs) enable real-time web search, improved referencing, and multilingual support, yet ensuring they provide safe health information remains crucial. This perspective evaluates seven publicly a…
View article: <i>IDH</i>-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation
<i>IDH</i>-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation Open
High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mu…
View article: A Personalized Risk Model for Azacitidine Outcome in Myelodysplastic Syndrome and Other Myeloid Neoplasms Identified by Machine Learning Model Utilizing Real-World Data
A Personalized Risk Model for Azacitidine Outcome in Myelodysplastic Syndrome and Other Myeloid Neoplasms Identified by Machine Learning Model Utilizing Real-World Data Open
Azacitidine is an approved therapy for higher-risk myelodysplastic syndrome (MDS). However, only 30–40% patients respond to azacitidine, and the responses may take up to six cycles to become evident. Delayed responses and the myelosuppress…
View article: Health Related Quality of Life of Hypertensive Patients attending a Tertiary Level Hospital in Kathmandu
Health Related Quality of Life of Hypertensive Patients attending a Tertiary Level Hospital in Kathmandu Open
Background: Hypertension among cardiovascular disease is one of the major components of non-communicable disease emerging as a global public health problem leading the risk for disability and death globally impairing health related quality…
View article: TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms
TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms Open
View article: Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes
Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes Open
Natalie Montarello, Alasdair Leslie, Rakchha Chhetri, Oisin Friel, Deepak Singhal, David Ross, David Yeung, Chung H. Kok, Peter J. Psaltis, and Devendra K. Hiwase
View article: Seronegative Rheumatoid Arthritis and Innate Immune Activation is Frequent in Myeloid Neoplasms with Isocitrate Dehydrogenase 1/2 Mutations
Seronegative Rheumatoid Arthritis and Innate Immune Activation is Frequent in Myeloid Neoplasms with Isocitrate Dehydrogenase 1/2 Mutations Open
View article: Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies
Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies Open
There is increasing recognition that pathogenic germ line variants drive the development of hematopoietic cancers in many individuals. Currently, patients with hereditary hematologic malignancies (HHMs) receive similar standard therapies a…
View article: Outcomes following venetoclax‐based treatment in therapy‐related myeloid neoplasms
Outcomes following venetoclax‐based treatment in therapy‐related myeloid neoplasms Open
Therapy‐related myeloid neoplasms (t‐MN) are aggressive malignancies in need of effective therapies. The BCL‐2 inhibitor venetoclax represents a paradigm shift in the treatment of acute myeloid leukemia. However, the effectiveness of venet…
View article: Respiratory Viruses Cause Late Morbidity in Recipients of Hematopoietic Stem Cell Transplantation
Respiratory Viruses Cause Late Morbidity in Recipients of Hematopoietic Stem Cell Transplantation Open
Common respiratory viral infections (CRVIs) frequently complicate hematopoietic stem cell transplantation (HSCT). We conducted a retrospective, single-center, observational cohort study to determine the incidence of CRVI in patients who re…
View article: FRI0016 MUTATIONAL LANDSCAPE OF MYELODYSPLASTIC SYNDROME IN PATIENTS WITH AUTOIMMUNE RHEUMATOLOGICAL DISORDERS
FRI0016 MUTATIONAL LANDSCAPE OF MYELODYSPLASTIC SYNDROME IN PATIENTS WITH AUTOIMMUNE RHEUMATOLOGICAL DISORDERS Open
View article: Red cell autoimmunization and alloimmunization in myelodysplastic syndromes: prevalence, characteristic and significance
Red cell autoimmunization and alloimmunization in myelodysplastic syndromes: prevalence, characteristic and significance Open
View article: Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome
Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome Open
Up to 90% of patients with a myelodysplastic syndrome require red blood cell transfusion; nevertheless, comprehensive data on red cell alloimmunization in such patients are limited. This study evaluates the incidence and clinical impact of…
View article: Dynamic assessment of RBC‐transfusion dependency improves the prognostic value of the revised‐IPSS in MDS patients
Dynamic assessment of RBC‐transfusion dependency improves the prognostic value of the revised‐IPSS in MDS patients Open
RBC‐transfusion dependency (RBC‐TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification‐based prognostic scoring system (WPSS) for MDS patients. However, WPSS did not include cytopenia, whereas revi…