Rohit Srivastava
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View article: Oncogenic Role of SATB2 In Vitro: Regulator of Pluripotency, Self-Renewal, and Epithelial–Mesenchymal Transition in Prostate Cancer
Oncogenic Role of SATB2 In Vitro: Regulator of Pluripotency, Self-Renewal, and Epithelial–Mesenchymal Transition in Prostate Cancer Open
Special AT-rich sequence binding protein-2 (SATB2) is a nuclear matrix protein that binds to nuclear attachment regions and is involved in chromatin remodeling and transcription regulation. In stem cells, it regulates the expression of gen…
View article: Clinical significance of <scp>PNO1</scp> as a novel biomarker and therapeutic target of hepatocellular carcinoma
Clinical significance of <span>PNO1</span> as a novel biomarker and therapeutic target of hepatocellular carcinoma Open
The RNA‐binding protein PNO1 plays an essential role in ribosome biogenesis. Recent studies have shown that it is involved in tumorigenesis; however, its role in hepatocellular carcinoma (HCC) is not well understood. The purpose of this st…
View article: INTERSECT Architecture Specification: System-of-Systems Architecture (V.0.9)
INTERSECT Architecture Specification: System-of-Systems Architecture (V.0.9) Open
Oak Ridge National Laboratory (ORNL)’s Self-driven Experiments for Science / Interconnected Science Ecosystem (INTERSECT) architecture project, titled “An Open Federated Architecture for the Laboratory of the Future”, creates an open feder…
View article: An Appraisal of Technological Interventions on Mustard Crop under Cluster Front Line Demonstrations
An Appraisal of Technological Interventions on Mustard Crop under Cluster Front Line Demonstrations Open
Aims: To boost production and profitability, The current study's evaluation of technical interventions focused on a cluster front line demonstration on mustard crop, which was carried out in the KVK's operational territory in district Bhad…
View article: Impact Analysis of Front Line Demonstration on Tomato under Mid Plain Agro-Climatic Zone of Uttar Pradesh, India
Impact Analysis of Front Line Demonstration on Tomato under Mid Plain Agro-Climatic Zone of Uttar Pradesh, India Open
Aims: Tomatoes benefit local farmers because of their excellent storage and truck-gardening capabilities. Because of local demand, tomatoes are a prominent commercial vegetable production in the Bhadohi area. A Frontline demonstration was …
View article: Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia
Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia Open
Purpose: To determine the maximum-tolerated dose (MTD) of the histone deacetylase inhibitor vorinostat combined with fixed doses of cytarabine (ara-C or cytosine arabinoside) and etoposide in patients with poor-risk or advanced acut…
View article: Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia
Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia Open
Purpose: To determine the maximum-tolerated dose (MTD) of the histone deacetylase inhibitor vorinostat combined with fixed doses of cytarabine (ara-C or cytosine arabinoside) and etoposide in patients with poor-risk or advanced acut…
View article: Supplementary Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia
Supplementary Data from Translational Phase I Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytarabine and Etoposide in Patients with Relapsed, Refractory, or High-Risk Acute Myeloid Leukemia Open
PDF file - 81 KB, Supplemental Table S1. Eligibility Criteria - NCT00357305 Supplemental Table S2: Characteristics of 21 patients enrolled in the study Supplemental Table S3. Cell cycle phase distribution Supplemental Table S3, continued. …
View article: Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application
Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application Open
Growth is crucially controlled by the functional ribosomes available in cells. To meet the enhanced energy demand, cancer cells re‐wire and increase their ribosome biogenesis. The RNA‐binding protein PNO1, a ribosome assembly factor, plays…
View article: Adopting ayurveda in health management complements “One health” approaches
Adopting ayurveda in health management complements “One health” approaches Open
View article: Correction to: Unraveling the ameliorative potentials of native lichen Pyxine cocoes (Sw.) Nyl., during COVID 19 phase
Correction to: Unraveling the ameliorative potentials of native lichen Pyxine cocoes (Sw.) Nyl., during COVID 19 phase Open
View article: INTERSECT Architecture Specification: System-of-systems Architecture (Version 0.5)
INTERSECT Architecture Specification: System-of-systems Architecture (Version 0.5) Open
Oak Ridge National Laboratory (ORNL)’s Self-driven Experiments for Science / Interconnected ScienceEcosystem (INTERSECT) architecture project, titled “An Open Federated Architecture for the Laboratory of the Future”, creates an open federa…
View article: “Unconventional” Causes of Acute Kidney Injury: A Critical Nuance of Interpretation and Intervention
“Unconventional” Causes of Acute Kidney Injury: A Critical Nuance of Interpretation and Intervention Open
Background: Acute kidney injury (AKI) is one of the most common clinical problems encountered by physicians in day-to-day practice which is associated with increased morbidity and mortality. The incidence of AKI is increasing so the right …
View article: Noninvasive Imaging-Guided In Vivo Estimation of Photothermal Therapy Using Cancer-Targeted Gold-Solid-Lipid Nanomaterial
Noninvasive Imaging-Guided In Vivo Estimation of Photothermal Therapy Using Cancer-Targeted Gold-Solid-Lipid Nanomaterial Open
Background: Photothermal therapy (PTT) is a promising cancer treatment modality which employs near-infrared laser on gold-nanomaterials for localized heat-mediated tumor ablation. We estimate PTT effect of a novel CSC-targeted photothermal…
View article: Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway
Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway Open
View article: Gender Affirming Laryngeal and Voice Surgery
Gender Affirming Laryngeal and Voice Surgery Open
Gender affirmation laryngeal and voice surgeries are components of “voice-lift” or cosmetic voice surgeries. Feminization surgery can modify vocal folds (fundamental frequency [Fo]) and vocal tract (resonance frequency). For increased pitc…
View article: Identification and validation of the wound and insect bite early inducible promoter from Arabidopsis thaliana
Identification and validation of the wound and insect bite early inducible promoter from Arabidopsis thaliana Open
View article: Chronic alcohol exposure induces hepatocyte damage by inducing oxidative stress, SATB2 and stem cell‐like characteristics, and activating lipogenesis
Chronic alcohol exposure induces hepatocyte damage by inducing oxidative stress, SATB2 and stem cell‐like characteristics, and activating lipogenesis Open
Alcohol is a risk factor for hepatocellular carcinoma (HCC). However, the molecular mechanism by which chronic alcohol consumption contributes to HCC is not well understood. The purpose of the study was to demonstrate the effects of chroni…
View article: Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐Kras<sup>G12D</sup>) mice
Ethanol exposure of human pancreatic normal ductal epithelial cells induces EMT phenotype and enhances pancreatic cancer development in KC (Pdx1‐Cre and LSL‐Kras<sup>G12D</sup>) mice Open
Alcohol is a risk factor for pancreatic cancer. However, the molecular mechanism by which chronic alcohol consumption influences pancreatic cancer development is not well understood. We have recently demonstrated that chronic ethanol expos…
View article: Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance Open
Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a m…
View article: Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India
Impact of COVID-19 on Patient Trends and Outcome: Results from a Tertiary Care Burn and Plastic Unit in Northern India Open
Background Burn and trauma injuries need emergency care and resuscitation, which required uninterrupted delivery of inpatient care services during the coronavirus disease 2019 (COVID-19) pandemic. Burn patients are physiologically immunoco…
View article: Emphysematous Pyelonephritis in Type 2 Diabetes – Clinical Profile and Management
Emphysematous Pyelonephritis in Type 2 Diabetes – Clinical Profile and Management Open
Emphysematous pyelonephritis (EPN) is a rare but life-threatening acute suppurative infection of the kidney among diabetics. There is no current consensus on the management of EPN. A prospective observational study was conducted at the Dep…
View article: ASYMPTOMATIC BACTERIURIA IN PREGNANCY AND COMPLICATIONS ASSOCIATED WITH ASYMPTOMATIC BACTERIURIA
ASYMPTOMATIC BACTERIURIA IN PREGNANCY AND COMPLICATIONS ASSOCIATED WITH ASYMPTOMATIC BACTERIURIA Open
Introduction- Urinary tract infections refers to both microbial colonization of urine and tissue invasion of any structure of urinary tract. ASYMPTOMATIC BACTERIURIA (ASB) is a condition in which urine culture reveals significant growth of…
View article: Enhancing early detection of neurological and developmental disorders and provision of intervention in low-resource settings in Uttar Pradesh, India: study protocol of the G.A.N.E.S.H. programme
Enhancing early detection of neurological and developmental disorders and provision of intervention in low-resource settings in Uttar Pradesh, India: study protocol of the G.A.N.E.S.H. programme Open
Introduction Around 9% of India’s children under six are diagnosed with neurodevelopmental disorders. Low-resource, rural communities often lack programmes for early identification and intervention. The Prechtl General Movement Assessment …
View article: SATB2 is a novel biomarker and therapeutic target for cancer
SATB2 is a novel biomarker and therapeutic target for cancer Open
Several studies have confirmed the involvement of cancer stem cells (CSC) in tumour progression, metastasis, drug resistance and cancer relapse. SATB2 (special AT‐rich binding protein‐2) acts as a transcriptional co‐factor and modulates ch…
View article: α‐Mangostin‐encapsulated PLGA nanoparticles inhibit colorectal cancer growth by inhibiting Notch pathway
α‐Mangostin‐encapsulated PLGA nanoparticles inhibit colorectal cancer growth by inhibiting Notch pathway Open
Colorectal cancer (CRC) is the fourth leading cause of cancer‐related mortality. Recent studies have stated that Notch signalling is highly activated in cancer stem cells (CSCs) and plays an important role in the development and progressio…
View article: Virtual Screening and Free Energy Estimation for Identifying Mycobacterium Tuberculosis Flavoenzyme DprE1 Inhibitors
Virtual Screening and Free Energy Estimation for Identifying Mycobacterium Tuberculosis Flavoenzyme DprE1 Inhibitors Open
we investigated the promising MTB drug target protein, DprE1 (decaprenylphosphoryl-β-d-ribose 2’-epimerase), involve in cell was synthesis of Mycobacterium tuberculosis and plays a crucial role in host pathogenesis, virulence, letha…
View article: Characterization and Classification of Soils on Quartzite-Schistose Landscape in Tropical Ecosystem of Goa–in a Topo-sequence
Characterization and Classification of Soils on Quartzite-Schistose Landscape in Tropical Ecosystem of Goa–in a Topo-sequence Open
Nine typical pedons representing major quartzite-schistose landscape in tropical ecosystem of Goa viz., high hills, restricted summits, low hills, inter-hilly valley and narrow valley under varying land use were studied for their morpholog…
View article: The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives
The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives Open
The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer‐related d…
View article: Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma
Assessment of risk factors, and racial and ethnic differences in hepatocellular carcinoma Open
Despite improved screening and surveillance guidelines, significant race/ethnicity‐specific disparities in hepatocellular carcinoma (HCC) continue to exist and disproportionately affect minority and disadvantaged populations. This trend in…