Ralf Helbig
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View article: Embossed sub-micron DLIP and LIPSS textures on polypropylene delay surface colonization of Staphylococcus aureus
Embossed sub-micron DLIP and LIPSS textures on polypropylene delay surface colonization of Staphylococcus aureus Open
The increasing bacterial resistance to antibiotics is prompting research into new approaches to design bacterial repellent surfaces. This work investigated the hot embossing of sub-micron direct laser interference patterning (DLIP) and las…
View article: Entropic repulsion of cholesterol-containing layers counteracts bioadhesion
Entropic repulsion of cholesterol-containing layers counteracts bioadhesion Open
Control of adhesion is a striking feature of living matter that is of particular interest regarding technological translation 1–3 . We discovered that entropic repulsion caused by interfacial orientational fluctuations of cholesterol layer…
View article: Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity
Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity Open
Bacterial colonization occurs on all biological and artificial surfaces in the oral cavity. The formation of multicellular biofilms or settlement of misallocated species can cause caries (diet‐depending acidification), periodontal diseases…
View article: Bioadhesion on Textured Interfaces in the Human Oral Cavity—An In Situ Study
Bioadhesion on Textured Interfaces in the Human Oral Cavity—An In Situ Study Open
Extensive biofilm formation on materials used in restorative dentistry is a common reason for their failure and the development of oral diseases like peri-implantitis or secondary caries. Therefore, novel materials and strategies that resu…
View article: Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening (Adv. Mater. 36/2021)
Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening (Adv. Mater. 36/2021) Open
Coatings In article number 2102349, Yixin Zhang and co-workers report an amphiphilic coating for glass surfaces, on which small droplets of polar aprotic organic solvents can be deposited with an enhanced contact angle (small feature size)…
View article: Understanding Beta-Lactam-Induced Lysis at the Single-Cell Level
Understanding Beta-Lactam-Induced Lysis at the Single-Cell Level Open
Mechanical rupture, or lysis, of the cytoplasmic membrane is a common cell death pathway in bacteria occurring in response to β-lactam antibiotics. A better understanding of the cellular design principles governing the susceptibility and r…
View article: Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening
Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening Open
The in situ synthesis of biomolecules on glass surfaces for direct bioscreening can be a powerful tool in the fields of pharmaceutical sciences, biomaterials, and chemical biology. However, it is still challenging to 1) achieve this conven…
View article: Entropic repulsion of cholesterol-containing lipid layers counteracts bioadhesion
Entropic repulsion of cholesterol-containing lipid layers counteracts bioadhesion Open
The authors have requested that this preprint be removed from Research Square.
View article: Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications
Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications Open
Background All soft and solid surface structures in the oral cavity are covered by the acquired pellicle followed by bacterial colonization. This applies for natural structures as well as for restorative or prosthetic materials; the adhere…
View article: Springtail-Inspired Triangular Laser-Induced Surface Textures on Metals Using MHz Ultrashort Pulses
Springtail-Inspired Triangular Laser-Induced Surface Textures on Metals Using MHz Ultrashort Pulses Open
Considering the attractive surface functionalities of springtails (Collembola), an attempt at mimicking their cuticular topography on metals is proposed. An efficient single-step manufacturing process has been considered, involving laser-i…
View article: Subwavelength Direct Laser Nanopatterning Via Microparticle Arrays for Functionalizing Metallic Surfaces
Subwavelength Direct Laser Nanopatterning Via Microparticle Arrays for Functionalizing Metallic Surfaces Open
Functionalized metallic nanofeatures can be selectively fabricated via ultrashort laser processing; however, the cost-effective large-area texturing, intrinsically constrained by the diffraction limit of light, remains a challenging issue.…
View article: Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity
Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity Open
Springtails (Collembola) have a nanostructured cuticle. To evaluate and to understand anti-biofouling properties of springtail cuticles’ morphology under different conditions, springtails, shed cuticles and cuticle replicates were studied …
View article: Data for figure 3 from Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity
Data for figure 3 from Impact of the springtail's cuticle nanotopography on bioadhesion and biofilm formation <i>in vitro</i> and in the oral cavity Open
Springtails (Collembola) have a nano-structured cuticle. To evaluate and to understand anti-biofouling properties of springtail cuticles’ morphology under different conditions, springtails, shed cuticles and cuticle replicates were studied…
View article: Direct laser interference patterning for decreased bacterial attachment
Direct laser interference patterning for decreased bacterial attachment Open
In the past 15 years, many efforts were made to create functionalized artificial surfaces showing special anti-bacterial and anti-biofouling properties. Thereby, the topography of medical relevant materials plays an important role. However…
View article: Impact of structure-dimensions on initial and short-term bacterial adhesion
Impact of structure-dimensions on initial and short-term bacterial adhesion Open
Event Abstract Back to Event Impact of structure-dimensions on initial and short-term bacterial adhesion Ralf Helbig1*, Jens Friedrichs1, Andrés Lasagni2* and Carsten Werner1* 1 Leibniz Institue of Polymer Research, Institute of Biofunctio…
View article: Evaluation of Surface Microtopography Engineered by Direct Laser Interference for Bacterial Anti-Biofouling
Evaluation of Surface Microtopography Engineered by Direct Laser Interference for Bacterial Anti-Biofouling Open
Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at s…