Ralf Salzer
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View article: Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery
Molecular structure of the ESCRT III-based archaeal CdvAB cell division machinery Open
Most prokaryotes divide using filaments of the tubulin-like FtsZ protein, while some archaea employ instead ESCRT-III-like proteins and their filaments for cell division and cytokinesis. The alternative archaeal system comprises Cdv protei…
View article: Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes
Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes Open
SUMMARY The ESCRT machinery performs a critical role in membrane remodelling events in all eukaryotic cells, including in membrane trafficking, membrane repair, cytokinetic abscission, in viral egress, and in the generation of extracellula…
View article: Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice Open
The COVID‐19 pandemic, caused by the SARS‐CoV‐2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin‐like Dps from hyperthermophilic Sulfolobus islandicus, covalently coupled with SARS‐CoV‐2 antigens via the…
View article: Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice Open
The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has triggered a worldwide health emergency. So far, several different types of vaccines have shown strong efficacy. However, both the emergence of new SARS-CoV-2 variants and the…
View article: A new twist on bacterial motility – two distinct type IV pili revealed by cryoEM
A new twist on bacterial motility – two distinct type IV pili revealed by cryoEM Open
Summary Many bacteria express flexible protein filaments on their surface that enable a variety of important cellular functions. Type IV pili are examples of such filaments and are comprised of a helical assembly of repeating pilin subunit…
View article: The traffic ATPase PilF interacts with the inner membrane platform of the DNA translocator and type IV pili from <i>Thermus thermophilus</i>
The traffic ATPase PilF interacts with the inner membrane platform of the DNA translocator and type IV pili from <i>Thermus thermophilus</i> Open
A major driving force for the adaptation of bacteria to changing environments is the uptake of naked DNA from the environment by natural transformation, which allows the acquisition of new capabilities. Uptake of the high molecular weight …
View article: Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus
Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus Open
Secretins form multimeric channels across the outer membrane of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type IV pili. The secretin complex of Thermus thermophilus is an oligomer of the 757…
View article: Structure of a type IV pilus machinery in the open and closed state
Structure of a type IV pilus machinery in the open and closed state Open
Proteins of the secretin family form large macromolecular complexes, which assemble in the outer membrane of Gram-negative bacteria. Secretins are major components of type II and III secretion systems and are linked to extrusion of type IV…
View article: Author response: Structure of a type IV pilus machinery in the open and closed state
Author response: Structure of a type IV pilus machinery in the open and closed state Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Proteins o…