Ralf Siegner
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View article: Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin Open
Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with deregulated gene expression and impaired tissue functionality, leading to the well-k…
View article: Modeling transcriptomic age using knowledge-primed artificial neural networks
Modeling transcriptomic age using knowledge-primed artificial neural networks Open
The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. Howeve…
View article: Topical treatment with coenzyme <scp>Q</scp>10‐containing formulas improves skin's <scp>Q</scp>10 level and provides antioxidative effects
Topical treatment with coenzyme <span>Q</span>10‐containing formulas improves skin's <span>Q</span>10 level and provides antioxidative effects Open
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid‐soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. He…