Ralf Thiele
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View article: Imaging of crystal-induced arthropathies in 2025
Imaging of crystal-induced arthropathies in 2025 Open
In recent years, imaging has become an essential tool in the assessment of crystal-induced arthropathies (CIAs), including gout, calcium pyrophosphate deposition disease, and basic calcium phosphate crystal deposition. Advances in imaging …
View article: Homogeneity Between Cervical and Vaginal Microbiomes and the Diagnostic Limitations of 16S Sequencing for STI Pathogens at Higher Ct Values
Homogeneity Between Cervical and Vaginal Microbiomes and the Diagnostic Limitations of 16S Sequencing for STI Pathogens at Higher Ct Values Open
Understanding the interactions between the cervico-vaginal microbiome, immune responses, and sexually transmitted infections (STIs) is crucial for developing targeted diagnostic and therapeutic strategies. Although microbiome analyses are …
View article: Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network
Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network Open
Background Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus nephritis. Methods Pa…
View article: Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria
Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria Open
The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadeni…
View article: Pragmatic Considerations When Extracting DNA for Metagenomics Analyses of Clinical Samples
Pragmatic Considerations When Extracting DNA for Metagenomics Analyses of Clinical Samples Open
Microbiome analyses are essential for understanding microorganism composition and diversity, but interpretation is often challenging due to biological and technical variables. DNA extraction is a critical step that can significantly bias r…
View article: Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
The PDF includes legends for Supplementary Tables S1 - S5 as well as legends for Supplementary Figures S1 - S3. Supplementary Figure S1 indicates pathogens detected in mice held in the SPF and conventional animal facility. Supplementary Fi…
View article: Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Health monitoring report of PAx5+/- held in the SPF and conventional animal facility.
View article: Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Pax5 target genes differentially express in p-BALL bearing Pax5+/- mice according to Delogu A. et al 2006, Schebesta A. et al 2007, and Revilla-i-Domingo R. et al 2012.
View article: Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We prese…
View article: Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Health monitoring report of PAx5+/- held in the SPF and conventional animal facility.
View article: Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Differentially expressed genes in bone marrow tumors from Pax5+/- mice compared to wild-type B220+ bone marrow B cells.
View article: Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Pax5 target genes differentially express in p-BALL bearing Pax5+/- mice according to Delogu A. et al 2006, Schebesta A. et al 2007, and Revilla-i-Domingo R. et al 2012.
View article: Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We prese…
View article: Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
SNVs detected by whole exam sequencing in the three index Pax5+/- pB-ALL.
View article: Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
SNVs detected by whole exam sequencing in the three index Pax5+/- pB-ALL.
View article: Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Total numbers and percentage of hematopoietic subsets in young Pax5+/- and wild type mice.
View article: Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
The PDF includes legends for Supplementary Tables S1 - S5 as well as legends for Supplementary Figures S1 - S3. Supplementary Figure S1 indicates pathogens detected in mice held in the SPF and conventional animal facility. Supplementary Fi…
View article: Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Total numbers and percentage of hematopoietic subsets in young Pax5+/- and wild type mice.
View article: Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Differentially expressed genes in bone marrow tumors from Pax5+/- mice compared to wild-type B220+ bone marrow B cells.
View article: Cost-Effective Next Generation Sequencing-Based STR Typing with Improved Analysis of Minor, Degraded and Inhibitor-Containing DNA Samples
Cost-Effective Next Generation Sequencing-Based STR Typing with Improved Analysis of Minor, Degraded and Inhibitor-Containing DNA Samples Open
Forensic DNA profiles are established by multiplex PCR amplification of a set of highly variable short tandem repeat (STR) loci followed by capillary electrophoresis (CE) as a means to assign alleles to PCR products of differential length.…
View article: Examining Different Analysis Protocols Targeting Hospital Sanitary Facility Microbiomes
Examining Different Analysis Protocols Targeting Hospital Sanitary Facility Microbiomes Open
Indoor spaces exhibit microbial compositions that are distinctly dissimilar from one another and from outdoor spaces. Unique in this regard, and a topic that has only recently come into focus, is the microbiome of hospitals. While the bene…
View article: Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial
Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial Open
Introduction Psoriatic arthritis (PsA) is a complex, immune-mediated disease associated with skin psoriasis that, if left untreated, can lead to joint destruction. Up to 30% of patients with psoriasis progress to PsA. In most cases, psoria…
View article: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) Following SARS-CoV2 Vaccination
Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) Following SARS-CoV2 Vaccination Open
A 67-year-old man presented with joint swelling, muscular weakness, pain and anemia after the second dose of BNT162b2 (Pfizer-Biontech) mRNA COVID-19 vaccination. The signs and symptoms in the case met criteria for post-vaccination polymya…
View article: Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells
Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells Open
Objective B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This stu…
Cartilage icing and chondrocalcinosis on knee radiographs in the differentiation between gout and calcium pyrophosphate deposition Open
In subjects with joint aspiration-proven crystal disease of the knee, the radiographic finding of cartilage icing was seen in both gout and CPPD. Chondrocalcinosis (overall and hyaline cartilage) as well as gastrocnemius tendon calcificati…
View article: Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets Open
Key Points Pediatric ALL relapses after allogeneic stem cell transplantation display highly diverse, dynamic and patient-individual genetic lesions. Nine of 10 relapsing pediatric transplant recipients present with genetic alterations for …
View article: Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors
Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors Open
Ewing´s Sarcoma Family of Tumors (ESFT) are clinically aggressive bone and soft tissue tumors in children and young adults. Analysis of the immune tumor microenvironment (TME) provides insight into tumor evolution and novel treatment optio…