Ralf Wiedemuth
YOU?
Author Swipe
View article: IKBKB gain of function: An inborn error with clinical heterogeneity progressing toward combined immunodeficiency
IKBKB gain of function: An inborn error with clinical heterogeneity progressing toward combined immunodeficiency Open
This study broadens the clinical spectrum of IKBKB gain-of-function variants as a progressive immunodeficiency in adulthood.
View article: IKAROS—how many feathers have you lost: mild and severe phenotypes in IKZF1 deficiency
IKAROS—how many feathers have you lost: mild and severe phenotypes in IKZF1 deficiency Open
Heterozygous germline variants in human IKZF1 encoding for IKAROS define an inborn error of immunity with immunodeficiency, immune dysregulation and risk of malignancy with a broad phenotypic spectrum. Growing evidence of underlying pathop…
View article: Supplementary Figure S4 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S4 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Comparison of FT-IR spectra and ATR FT-IR spectra of brain tissue.
View article: Supplementary Table S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Table S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Cryosections of human brain tumor samples
View article: Data from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Data from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Purpose: Somatic mutations in the human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fouri…
View article: Data from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Data from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Purpose: Somatic mutations in the human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fouri…
View article: Supplementary Table S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Table S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Fresh, unfixed biopsies of human brain tumor samples.
View article: Supplementary Figure S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Western Blot analysis of genetically engineered IDH1-wt and IDH1-mut cell lines.
View article: Supplementary Table S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Table S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Cryosections of human brain tumor samples
View article: Supplementary Figure S3 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S3 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Cell density in IDH1-wt and IDH1-mut human glioma samples.
View article: Supplementary Figure S4 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S4 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Comparison of FT-IR spectra and ATR FT-IR spectra of brain tissue.
View article: Supplementary Figure S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
FT-IR imaging.
View article: Supplementary Figure S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
FT-IR imaging.
View article: Supplementary Figure S3 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S3 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Cell density in IDH1-wt and IDH1-mut human glioma samples.
View article: Supplementary Figure S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Figure S1 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Western Blot analysis of genetically engineered IDH1-wt and IDH1-mut cell lines.
View article: Supplementary Table S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status
Supplementary Table S2 from Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the <i>IDH1</i> Mutation Status Open
Fresh, unfixed biopsies of human brain tumor samples.
View article: Listening to the Whispers in Neuroimmune Crosstalk: A Comprehensive Workflow to Investigate Neurotrophin Receptor p75NTR Under Endogenous, Low Abundance Conditions
Listening to the Whispers in Neuroimmune Crosstalk: A Comprehensive Workflow to Investigate Neurotrophin Receptor p75NTR Under Endogenous, Low Abundance Conditions Open
Inflammatory conditions are critically influenced by neuroimmune crosstalk. Cytokines and neurotrophic factors shape the responses of both nervous and immune systems. Although much progress has been made, most findings to date are based on…
View article: Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin Open
IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), whereas IDH1R132H u…
View article: The Dox-pDC - A murine conditionally immortalized plasmacytoid dendritic cell line with native immune profile
The Dox-pDC - A murine conditionally immortalized plasmacytoid dendritic cell line with native immune profile Open
Plasmacytoid dendritic cells (pDC) constitute a very rare blood cell population and play a significant role in immune response and immune-mediated disorders. Investigations on primary pDCs are hindered not only due to their rarity but also…
View article: Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells
Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells Open
Our data suggest that increased Survivin levels promote adaptive evolution of tumors through combining induction of genetic heterogeneity with inhibition of apoptosis.
View article: An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment
An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment Open
View article: Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny
Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny Open
The mitotic Aurora B kinase is overexpressed in tumors and various inhibitors for Aurora B are currently under clinical assessments. However, when considering Aurora B kinase inhibitors as anticancer drugs, their mode of action and the rol…
View article: MPTH-11ANAPLASTIC MENINGIOMAS WHO GRADE III LACK OF SOMATIC AKT1-MUTATIONS AND SHOW AN OVEREXPRESSION OF EGF-RECEPTORS
MPTH-11ANAPLASTIC MENINGIOMAS WHO GRADE III LACK OF SOMATIC AKT1-MUTATIONS AND SHOW AN OVEREXPRESSION OF EGF-RECEPTORS Open
BACKGROUND: The AKT1 mutation was newly described in a subset of meningiomas and inhibitors of this mutation have shown promise in clinical trials in multiple cancer types. We sought to determine the frequency of the AKT1 mutation as well …