Ralitsa Raycheva
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View article: Access to Orphan Medicinal Products in Bulgaria: An Analysis of the Positive Drug List and Individual Access Schemes
Access to Orphan Medicinal Products in Bulgaria: An Analysis of the Positive Drug List and Individual Access Schemes Open
Background/Objectives: Orphan medicinal products offer essential treatments for rare diseases, but patient access varies across European Union countries despite a common regulatory framework. In Bulgaria, access is primarily through inclus…
View article: Hormonal Profile in Women with Diabetes Mellitus Type 1 and Polycystic Ovary Syndrome – Is It Comparable to the Classic Syndrome?
Hormonal Profile in Women with Diabetes Mellitus Type 1 and Polycystic Ovary Syndrome – Is It Comparable to the Classic Syndrome? Open
Development of polycystic ovary syndrome (PCOS) like phenotype in women with diabetes mellitus type 1 (DMt1) on intensified insulin treatment is related to the subcutaneous insulin administration and leads to clinical and biochemical hyper…
View article: Humoral and Memory B Cell Responses Following SARS-CoV-2 Infection and mRNA Vaccination
Humoral and Memory B Cell Responses Following SARS-CoV-2 Infection and mRNA Vaccination Open
Background: Understanding the duration and quality of immune memory following SARS-CoV-2 infection and vaccination is critical for informing public health strategies and vaccine development. While waning antibody levels have raised concern…
View article: Influence of Ordinary Cigarettes and Their Substitute IQOS® on Secretory Immunoglobulin A in Unstimulated Saliva
Influence of Ordinary Cigarettes and Their Substitute IQOS® on Secretory Immunoglobulin A in Unstimulated Saliva Open
Background: Secretory immunoglobulin A (sIgA) plays a key role in oral and mucosal immunity, serving as a first-line defense against pathogens. Smoking is known to negatively affect immune function, but data on the impact of heated tobacco…
View article: Colorimetric RT-LAMP for SARS-CoV-2 detection from nasopharyngeal swabs or crude saliva: a multicountry diagnostic accuracy study in Africa
Colorimetric RT-LAMP for SARS-CoV-2 detection from nasopharyngeal swabs or crude saliva: a multicountry diagnostic accuracy study in Africa Open
View article: Infiltration level of CPP-ACFP (MI Varnish™), self-assembling peptide P11-4 (Curodont™ Repair), and newly synthesized fluorinated self-assembling peptides in artificial enamel initial carious lesions on smooth surfaces assessed by laser confocal microscopy – an in vitro study
Infiltration level of CPP-ACFP (MI Varnish™), self-assembling peptide P11-4 (Curodont™ Repair), and newly synthesized fluorinated self-assembling peptides in artificial enamel initial carious lesions on smooth surfaces assessed by laser confocal microscopy – an in vitro study Open
Aim : The aim of this study was to compare the lesion depth and level of penetration of CPP-ACFP, SAP P 11 -4 and 2 newly synthesized self-assembling peptides by measuring the linear depth of fluorescence. Materials and methods : A total o…
View article: Decreased risk of nosocomial transmission of hepatitis B and C viruses among hemodialysis patients in Southern Bulgaria
Decreased risk of nosocomial transmission of hepatitis B and C viruses among hemodialysis patients in Southern Bulgaria Open
Introduction: Hepatitis B (HBV) and (HCV) virus infections represent a nosocomial risk in hemodialysis (HD) patients. We aimed to evaluate the risk among adult HD patients in southern Bulgaria. Methodology: A prospective cohort study inclu…
View article: EPIDEMIOLOGICAL INVESTIGATION OF THE CLINICAL MANIFESTATION OF BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAWS IN 112 ONCOLOGY PATIENTS
EPIDEMIOLOGICAL INVESTIGATION OF THE CLINICAL MANIFESTATION OF BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAWS IN 112 ONCOLOGY PATIENTS Open
Background: Bisphosphonate-associated osteonecrosis of the jaws (BAONJ) is a condition linked to the intake of Bisphosphonates (BP) and clinically manifesting in mucosal ulceration and exposure of underlying necrotic bone. The aim of the s…
View article: MALDI - TOF MS for Direct Identification of Pathogens from Positive Blood Cultures – Modified New Protocol
MALDI - TOF MS for Direct Identification of Pathogens from Positive Blood Cultures – Modified New Protocol Open
View article: Evaluation of psychosocial work environment among healthcare professionals in cardiac care units
Evaluation of psychosocial work environment among healthcare professionals in cardiac care units Open
Introduction : Modern healthcare organizations and medical institutions depend on several factors, including the psychological environment as part of organizational culture. The psychological climate is multifaceted and difficult to quanti…
View article: Infective Endocarditis—Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria
Infective Endocarditis—Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria Open
Despite enormous developments in medicine, infective endocarditis (IE) remains an ongoing issue for physicians due to increased morbidity and persistently high mortality. Our goal was to assess clinical outcomes in patients with IE and ide…
View article: The modernisation of newborn screening as a pan-European challenge – An international delphi study
The modernisation of newborn screening as a pan-European challenge – An international delphi study Open
Newborn screening is a public health measure to diagnose rare diseases at birth, thereby minimising negative effects of late treatment. Genomic technologies promise an unprecedented expansion of screened diseases at low cost and with trans…
View article: Application of the bow-tie analysis to improve patient safety – a lesson learned from clinical practice
Application of the bow-tie analysis to improve patient safety – a lesson learned from clinical practice Open
Aim : This study aimed to assess the risk management of drug safety in an operating theater setting within a hospital-based treatment facility. Materials and methods : This is a case study detailing a single patient. The bow-tie model was …
View article: Infective Endocarditis – Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria
Infective Endocarditis – Predictors of In-Hospital Mortality, 17 Years, Single-Center Experience in Bulgaria Open
Background: Despite tremendous advances in medicine, infective endocarditis (IE) continues to be a challenge for physicians due to increasing morbidity and unchanged high mortality. Objectives: Our aim was to evaluate clinical outcomes in …
View article: Trend in Infective Endocarditis in Bulgaria: Characteristics and Outcome, 17-Years, Single Center Experience
Trend in Infective Endocarditis in Bulgaria: Characteristics and Outcome, 17-Years, Single Center Experience Open
Background: Infective endocarditis (IE) remains a difficult disease to diagnose and treat, with a persistently high mortality rate. There is a lack of recent data on IE in Bulgaria over the last decades. Methods: This study is retrospectiv…
View article: Trend in Infective Endocarditis in Bulgaria – Characteristics and Outcome, 17- Years, Single Center Experience
Trend in Infective Endocarditis in Bulgaria – Characteristics and Outcome, 17- Years, Single Center Experience Open
Background: Infective endocarditis (IE) remains a difficult disease to diagnose and treat, with a persistently high mortality rate. There is a lack of recent data on IE in Bulgaria over the last decades. Methods: The study is retrospective…
View article: Monitoring compliance with the rules of antiseptics and decontamination by dental students at work
Monitoring compliance with the rules of antiseptics and decontamination by dental students at work Open
Introduction : Dental personnel are potentially exposed to pathogenic microorganisms, as well as to possible sources of infection. The same is true for dental students, for whom it is crucial to acquire knowledge on infection control and a…
View article: Infective Endocarditis—Characteristics and Prognosis According to the Affected Valves
Infective Endocarditis—Characteristics and Prognosis According to the Affected Valves Open
Background: Infective endocarditis (IE) continues to be a disease with high mortality despite medical advances. Objective: The objective of this study was to investigate the characteristics and prognosis of IE according to the affected val…
View article: Deep learning in oral surgery for third molar extraction: empirical evidence and original model
Deep learning in oral surgery for third molar extraction: empirical evidence and original model Open
Preemptive analgesia is an analgesic intervention to influence postoperative pain sensation. Control of postoperative pain is a major challenge for any surgeon. Adequate control of postoperative pain continues to be a challenge for modern …
View article: Landscape analysis of available European data sources amenable for machine learning and recommendations on usability for rare diseases screening
Landscape analysis of available European data sources amenable for machine learning and recommendations on usability for rare diseases screening Open
Background Patient registries and databases are essential tools for advancing clinical research in the area of rare diseases, as well as for enhancing patient care and healthcare planning. The primary aim of this study is a landscape analy…
View article: COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities
COVID-19 vaccination and potential predictors for vaccination among students in Bulgarian medical universities Open
University students, especially those in healthcare sciences, are of particular importance in COVID-19 vaccine views since their future careers will allow them to educate citizens regarding vaccination. The study examined COVID-19 immunisa…
View article: Infective Endocarditis – Characteristics and Prognosis according to the Affected Valves.
Infective Endocarditis – Characteristics and Prognosis according to the Affected Valves. Open
Background: Infective endocarditis (IE) continues to be a disease with high mortality despite medical advances. Objective: To investigate the characteristics and prognosis of IE according to the affected valves. Material and methods: The s…
View article: Sex-related Differences in the Orbital Area of Bulgarians – a 3D Laser Scanning
Sex-related Differences in the Orbital Area of Bulgarians – a 3D Laser Scanning Open
The present study aimed to provide up-to-date information on normal sex-related dimensions of the orbital region in young Bulgarian adults, using a 3D laser scanner. The three-dimensional coordinates of several soft-tissue landmarks on the…
View article: Acute Management of Deep Periorbital Burns: A 10-Year Review of Experience.
Acute Management of Deep Periorbital Burns: A 10-Year Review of Experience. Open
Deep periorbital burns are an important issue mainly due to the presence of the eyes in the region, and the crucial importance of preservation of vision. There is no consensus regarding their treatment. A retrospective analysis of the trea…
View article: Expression of HIF-1α, Ki67, SMA and E-cadherin in endometriosis, endometrial and ovarian carcinoma
Expression of HIF-1α, Ki67, SMA and E-cadherin in endometriosis, endometrial and ovarian carcinoma Open
Introduction : Endometriosis is a benign gynecological condition that shares many characteristics with cancer cells, including immune evasion, survival, adhesion, invasion, and angiogenesis. The simultaneous investigation of tissue hypoxia…
View article: CHILDREN SOMATOTYPE STUDY OF DIFFERENT ETHNIC GROUPS FROM PLOVDIV REGION, BULGARIA
CHILDREN SOMATOTYPE STUDY OF DIFFERENT ETHNIC GROUPS FROM PLOVDIV REGION, BULGARIA Open
The purpose of the present study was to determine and compare the children's somatotypes of three ethnic groups living in the Plovdiv region, Bulgaria. Material and Methods: A cohort of 194 children were enrolled in the study. They were di…
View article: Clinical and virological profile of locally acquired acute hepatitis E in South Bulgaria
Clinical and virological profile of locally acquired acute hepatitis E in South Bulgaria Open
Introduction: Acute hepatitis E virus (HEV) infection is recognized as a zoonosis in several European countries. We describe the characteristics and outcomes of locally acquired acute HEV hepatitis. Methodology: A prospective study was con…
View article: Are the European reference networks for rare diseases ready to embrace machine learning? A mixed-methods study
Are the European reference networks for rare diseases ready to embrace machine learning? A mixed-methods study Open
Background The delay in diagnosis for rare disease (RD) patients is often longer than for patients with common diseases. Machine learning (ML) technologies have the potential to speed up and increase the precision of diagnosis in this popu…
View article: Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit—Incidence and Strategies for Prevention
Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit—Incidence and Strategies for Prevention Open
The second most prevalent healthcare-associated infection in neonatal intensive care units (NICUs) is ventilator-associated pneumonia (VAP). This review aims to update the knowledge regarding the incidence of neonatal VAP and to summarize …
View article: Laser biomodification of the bone bed surface for placement of spiral dental implants: a study based on scanning electron microscopy
Laser biomodification of the bone bed surface for placement of spiral dental implants: a study based on scanning electron microscopy Open
Introduction : Various rotary and mechanical instruments are used in conventional oral surgery for osteotomies. Despite the implementation of effective cooling systems, it is difficult to prevent thermal damage to the adjacent bone caused …