Ralph Trane
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View article: Life Course Modifiable Risk Factors of Dementia: Replicating the 2024 Lancet Commission Model in a Single Longitudinal Cohort
Life Course Modifiable Risk Factors of Dementia: Replicating the 2024 Lancet Commission Model in a Single Longitudinal Cohort Open
Background Findings of the 2024 Lancet Commission suggest nearly 40% of dementia prevalence could be reduced by eliminating a set of 14 modifiable risk factors. Although promising, effect estimates derived from meta‐analytic approaches can…
View article: Effects of Processing Deviations on Plasma Concentrations of AD Biomarkers
Effects of Processing Deviations on Plasma Concentrations of AD Biomarkers Open
Background Blood‐based biomarkers have emerged as a promising tool for detecting the presence of Alzheimer’s disease (AD) pathology in vivo, offering a practical alternative to more costly and invasive biomarker approaches. However, as the…
View article: Dementia prevalence in the Wisconsin Longitudinal Study
Dementia prevalence in the Wisconsin Longitudinal Study Open
INTRODUCTION While there is growing appreciation of the importance of sociobiological determinants of dementia, few lifespan cohorts offer well‐characterized dementia outcomes to explore these aims. We sought to identify dementia prevalenc…
View article: The association between mid‐life personality traits and late‐life dementia risk in the Wisconsin Longitudinal Study
The association between mid‐life personality traits and late‐life dementia risk in the Wisconsin Longitudinal Study Open
Background Personality traits, namely higher neuroticism and lower conscientiousness, are predictive of dementia, although the complex relationship has yet to be fully explained. With >60 years of prospectively collected data, the Wisconsi…
View article: EARLY LIFE INFLUENCES ON LATER LIFE ADRD RISK: THE ROLES OF ADOLESCENT COGNITIVE FUNCTION AND EDUCATION
EARLY LIFE INFLUENCES ON LATER LIFE ADRD RISK: THE ROLES OF ADOLESCENT COGNITIVE FUNCTION AND EDUCATION Open
By some estimates, each additional year of education reduces dementia risk by 7 percent. What remains unclear, however, is how early life cognitive function, which influences educational attainment, and is hypothesized to influence later l…
View article: Mid‐life occupational hazardous exposures is associated with late‐life dementia risk in the Wisconsin Longitudinal Study
Mid‐life occupational hazardous exposures is associated with late‐life dementia risk in the Wisconsin Longitudinal Study Open
Background Exposures to environmental toxicants and pollutants occur at various points along the life course, with mounting evidence that late‐life pollution exposure increases risk for neurological disease, including dementia. Although oc…
View article: MID-LIFE AND LATE-LIFE ENVIRONMENTAL EXPOSURES ON DEMENTIA RISK: THE MODIFYING EFFECTS OF APOE
MID-LIFE AND LATE-LIFE ENVIRONMENTAL EXPOSURES ON DEMENTIA RISK: THE MODIFYING EFFECTS OF APOE Open
Increasing evidence supports a deleterious effect of late-life air pollution exposure on dementia risk that is exacerbated among older ApolipoproteinE-4 (ApoE-4) carriers. However, the protracted effects of mid-life occupational exposures …
View article: Midlife and late‐life environmental exposures on dementia risk in the Wisconsin Longitudinal Study: The modifying effects of ApoE
Midlife and late‐life environmental exposures on dementia risk in the Wisconsin Longitudinal Study: The modifying effects of ApoE Open
INTRODUCTION Late‐life air pollution exposure is associated with an increased risk for dementia, with this effect exacerbated among apolipoprotein E‐4 (ApoE‐4) carriers. However, whether midlife occupational exposures likewise influence de…
View article: Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma
Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma Open
Enhanced, local ocular production of TGF-β2 with a robust positive association with IOP was identified in this spontaneous feline glaucoma model, providing a foundation for preclinical testing of novel therapeutics to limit disease-associa…
View article: Propensity Score Modeling: Key Challenges When Moving Beyond the No-Interference Assumption
Propensity Score Modeling: Key Challenges When Moving Beyond the No-Interference Assumption Open
The paper presents some models for the propensity score. Considerable attention is given to a recently popular, but relatively under-explored setting in causal inference where the no-interference assumption does not hold. We lay out some k…
View article: Propensity Score Modeling: Key Challenges When Moving Beyond the No-Interference Assumption
Propensity Score Modeling: Key Challenges When Moving Beyond the No-Interference Assumption Open
The paper presents some models for the propensity score. Considerable attention is given to a recently popular, but relatively under-explored setting in causal inference where the no-interference assumption does not hold. We lay out some k…
View article: Nonparametric bounds in two‐sample summary‐data Mendelian randomization: Some cautionary tales for practice
Nonparametric bounds in two‐sample summary‐data Mendelian randomization: Some cautionary tales for practice Open
Recently, in genetic epidemiology, Mendelian randomization (MR) has become a popular approach to estimate causal exposure effects by using single nucleotide polymorphisms from genome‐wide association studies (GWAS) as instruments. The most…
View article: Mapping retinal ganglion cell somas in a large-eyed glaucoma model.
Mapping retinal ganglion cell somas in a large-eyed glaucoma model. Open
As in other species, RGC soma count and topography are heterogeneous between individual cats, but we identified an ROI in the temporal retina for future studies of RGC soma loss or preservation in a large-eyed model of congenital glaucoma.…
View article: Validation of Peek Acuity application in pediatric screening programs in Paraguay
Validation of Peek Acuity application in pediatric screening programs in Paraguay Open
Peek Acuity represents an efficient tool that has potential for implementation in school screenings with different strategies aimed at pediatric populations due to its low cost and high specificity. An increase in sensitivity would improve…
View article: Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma
Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma Open
Objective To determine the effect of feline congenital glaucoma ( FCG ) on corneal sensitivity, and relationships between corneal sensitivity, central corneal thickness ( CT ), and corneal diameter ( CD ). Animals and Procedures Corneal se…
View article: Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone
Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone Open
Glucocorticoids such as dexamethasone can cause an increase in intraocular pressure (IOP) in some of the population, but not all. In this paper we used a mouse model of glucocorticoid induced ocular hypertension to examine the changes in t…