Ralph Wendt
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View article: Characteristics and Management of Patients With Immune Thrombotic Thrombocytopenic Purpura Admitted to the Intensive Care Unit: A Multicenter Retrospective Analysis
Characteristics and Management of Patients With Immune Thrombotic Thrombocytopenic Purpura Admitted to the Intensive Care Unit: A Multicenter Retrospective Analysis Open
Symptoms, management and outcomes of patients with immune TTP admitted to the intensive care unit.
View article: Urinary Peptidomic Profiling in Post-Acute Sequelae of SARS-CoV-2 Infection: A Case-Control Study
Urinary Peptidomic Profiling in Post-Acute Sequelae of SARS-CoV-2 Infection: A Case-Control Study Open
Background Post-acute sequelae of severe acute respiratory syndrome coronavirus 2-infection (PASC) is challenging to diagnose and treat, and its molecular pathophysiology remains unclear. Urinary peptidomics can provide valuable informatio…
View article: #2794 Specific urinary peptidomic profiling in patients with post-COVID-19: a case-control study (UriCoV)
#2794 Specific urinary peptidomic profiling in patients with post-COVID-19: a case-control study (UriCoV) Open
Background and Aims Post-COVID-19 (PC) is challenging to diagnose and treat, and its molecular pathophysiology is unclear. Urinary peptidomics is an unexplored area in PC research and could address this knowledge gap by providing informati…
View article: Acute kidney injury and hyponatremia in hospitalized patients with rotavirus infection
Acute kidney injury and hyponatremia in hospitalized patients with rotavirus infection Open
Introduction Rotavirus is a common cause of infectious gastroenteritis in infants and children. The role of rotavirus infections in adults has potentially been underappreciated and there is a paucity of data on incidence and outcome of acu…
View article: Short and long-term outcomes of children and adolescents hospitalized with COVID-19 or influenza: results of the AUTCOV study
Short and long-term outcomes of children and adolescents hospitalized with COVID-19 or influenza: results of the AUTCOV study Open
View article: The choice of surgical aortic valve replacement type and mid-term outcomes in 50 to 65-year-olds: results of the AUTHEARTVISIT study
The choice of surgical aortic valve replacement type and mid-term outcomes in 50 to 65-year-olds: results of the AUTHEARTVISIT study Open
OBJECTIVES In recent years, the use of biological prosthetic valves has increased in patients under 65 years of age. This study evaluated overall survival, major adverse cardiac events and reoperation risk following surgical aortic valve r…
View article: Baseline medication load and long-term outcomes in COVID-19-hospitalized patients: results of the AUTCOVSTUDY
Baseline medication load and long-term outcomes in COVID-19-hospitalized patients: results of the AUTCOVSTUDY Open
Introduction Limited data are available on long-term morbidity and mortality after hospitalization for coronavirus disease 2019 (COVID-19). In this registry-based study, we investigated long-term mortality and morbidity following hospitali…
View article: Urinary collagen peptides predict mortality
Urinary collagen peptides predict mortality Open
Background Organ fibrosis caused by the presence of excessive extracellular matrix (ECM) is strongly related to mortality. Urinary peptide signatures were reported predictive of death in SARS-CoV-2 and chronic kidney disease. Such signatur…
View article: Monitoring Plasma Concentrations of Intravenously Administered Fosfomycin to Prevent Drug-Related Adverse Events: A Retrospective Observational Study
Monitoring Plasma Concentrations of Intravenously Administered Fosfomycin to Prevent Drug-Related Adverse Events: A Retrospective Observational Study Open
Background: Fosfomycin is used as a combination partner for the treatment of severe non-urinary tract infections. Individualized dosing of fosfomycin based on therapeutic drug monitoring (TDM) has the potential to reduce drug-related adver…
View article: Association between surgical aortic valve replacement and long-term outcomes in 50 to 65-year-olds: Results of the AUTHEARTVISIT study
Association between surgical aortic valve replacement and long-term outcomes in 50 to 65-year-olds: Results of the AUTHEARTVISIT study Open
Objectives During the last years, age recommendations for the use of biological prostheses rather than mechanical prostheses for surgical aortic valve replacement (sAVR) have been lowered considerably. We evaluated survival rates, major ad…
View article: Case report: Ectopic production of intact parathyroid hormone (iPTH) by malignoma mimicking primary hyperparathyroidism
Case report: Ectopic production of intact parathyroid hormone (iPTH) by malignoma mimicking primary hyperparathyroidism Open
Background Malignant hypercalcemia is usually caused by osteolytic processes of metastases, production of parathormone-related peptide, or secretion of 1,25-dihydroxyvitamin D. Ectopic PTH (parathyroid hormone) production by malignancy is …
View article: Serum uromodulin associates with kidney function and outcome in a cohort of hospitalised COVID-19 patients
Serum uromodulin associates with kidney function and outcome in a cohort of hospitalised COVID-19 patients Open
View article: An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes
An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes Open
There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern ne…
View article: Baseline drug treatments and long-term outcomes in COVID- 19-hospitalized patients: results of the 2020 AUTCOV study
Baseline drug treatments and long-term outcomes in COVID- 19-hospitalized patients: results of the 2020 AUTCOV study Open
Limited data are available on long-term morbidity and mortality after COVID-19 hospitalization. In this population-based study, we investigated the long-term mortality and morbidity after COVID-19 hospitalization and associations with base…
View article: Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study
Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study Open
Background/Objectives: Survival prospects following SARS-CoV-2 infection may extend beyond the acute phase, influenced by various factors including age, health conditions, and infection severity; however, this topic has not been studied in…
View article: An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes
An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes Open
There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern ne…
View article: Short- and Long-term Outcomes of children hospitalized with COVID-19 or Influenza: results of the AUTCOV study
Short- and Long-term Outcomes of children hospitalized with COVID-19 or Influenza: results of the AUTCOV study Open
Background Recent literature gives different results on morbidity and mortality after COVID-19 as compared to Influenza hospitalized children and results of large, population based studies are scant. In this population-based study in Austr…
View article: Mortality Risk and Urinary Proteome Changes of Acute COVID-19 Survivors in the Multinational Study CRIT-COV-U Study
Mortality Risk and Urinary Proteome Changes of Acute COVID-19 Survivors in the Multinational Study CRIT-COV-U Study Open
Background/Objectives: Survival prospects following SARS-CoV-2 infection may extend beyond the acute phase, influenced by various factors including age, health conditions, and infection se-verity. However, this topic has not been studied i…
View article: Mortality risk in survivors of acute COVID-19 and the urinary proteome: Follow-up results from a multinational study that prospectively evaluated a proteomic urine test for early and accurate prognosis of critical course complications in patients with SARS-CoV-2 infection (CRIT-COV-U)
Mortality risk in survivors of acute COVID-19 and the urinary proteome: Follow-up results from a multinational study that prospectively evaluated a proteomic urine test for early and accurate prognosis of critical course complications in patients with SARS-CoV-2 infection (CRIT-COV-U) Open
Survival prospects following SARS-CoV-2 infection extend beyond the acute phase, influenced by various factors including age, health conditions, and infection severity. We investigated mortality risk among 651 post-acute COVID-19 patients,…
View article: Selection for transcatheter versus surgical aortic valve replacement and mid-term survival: results of the AUTHEARTVISIT study
Selection for transcatheter versus surgical aortic valve replacement and mid-term survival: results of the AUTHEARTVISIT study Open
OBJECTIVES Limited data are available from randomized trials comparing outcomes between transcatheter aortic valve replacement (TAVR) and surgery in patients with different risks and with follow-up of at least 4 years or longer. In this la…
View article: #1466 Age- and kidney function-dependent life expectancy of patients after COVID-19
#1466 Age- and kidney function-dependent life expectancy of patients after COVID-19 Open
Background and Aims The life expectancy among survivors of SARS-CoV-2 infection may be influenced by age, pre-existing health conditions, and the severity of the initial infection. This study aimed to investigate the life expectancy in pat…
View article: Assessment and Risk Prediction of Chronic Kidney Disease and Kidney Fibrosis Using Non-Invasive Biomarkers
Assessment and Risk Prediction of Chronic Kidney Disease and Kidney Fibrosis Using Non-Invasive Biomarkers Open
Effective management of chronic kidney disease (CKD), a major health problem worldwide, requires accurate and timely diagnosis, prognosis of progression, assessment of therapeutic efficacy, and, ideally, prediction of drug response. Multip…
View article: Non-Invasive Biomarkers for Diagnosis, Risk Prediction, and Therapy Guidance of Glomerular Kidney Diseases: A Comprehensive Review
Non-Invasive Biomarkers for Diagnosis, Risk Prediction, and Therapy Guidance of Glomerular Kidney Diseases: A Comprehensive Review Open
Effective management of glomerular kidney disease, one of the main categories of chronic kidney disease (CKD), requires accurate diagnosis, prognosis of progression, assessment of therapeutic efficacy, and, ideally, prediction of drug resp…
View article: Differentiating primary and secondary FSGS using non-invasive urine biomarkers
Differentiating primary and secondary FSGS using non-invasive urine biomarkers Open
Background Focal segmental glomerulosclerosis (FSGS) is divided into genetic, primary (p), uncertain cause, and secondary (s) forms. The subclasses differ in management and prognosis with differentiation often being challenging. We aimed t…
View article: Use of Urea for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Use of Urea for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone Open
Importance Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are associated with significant mortality and morbidity. The effectiveness and safety of oral urea for SIADH are still debated. Objective T…
View article: Glycosylation of bacterial antigens changes epitope patterns
Glycosylation of bacterial antigens changes epitope patterns Open
Introduction Unlike glycosylation of proteins expressed in mammalian systems, bacterial glycosylation is often neglected in the development of recombinant vaccines. Methods Here, we compared the effects of glycosylation of YghJ, an Escheri…
View article: Revisiting aortic valve prosthesis choice in patients younger than 50 years: 10 years results of the AUTHEARTVISIT study
Revisiting aortic valve prosthesis choice in patients younger than 50 years: 10 years results of the AUTHEARTVISIT study Open
OBJECTIVES This population-based cohort study investigated mid-term outcome after surgical aortic valve replacement with a bioprosthetic or mechanical valve prosthesis in patients aged <50 years in a European social welfare state. METHO…
View article: Selection for Transcatheter versus Surgical Aortic Valve Replacement and Long-term Survival: 10-year Results of the AUTHEARTVISIT Study
Selection for Transcatheter versus Surgical Aortic Valve Replacement and Long-term Survival: 10-year Results of the AUTHEARTVISIT Study Open
Background Limited data are available from randomized trials comparing outcomes between transcatheter aortic valve replacement (TAVR) and surgery in patients with different risks and with follow-up >2 years. Objective In this large, pop…
View article: Dynamics of urine proteomics biomarker and disease progression in patients with IgA nephropathy
Dynamics of urine proteomics biomarker and disease progression in patients with IgA nephropathy Open
Background Immunoglobulin A nephropathy (IgAN) frequently leads to kidney failure. The urinary proteomics-based classifier IgAN237 may predict disease progression at the time of kidney biopsy. We studied whether IgAN237 also predicts progr…
View article: #2561 URINE PROTEOMICS FOR PREDICTION OF DISEASE PROGRESSION IN PATIENTS WITH IGA NEPHROPATHY
#2561 URINE PROTEOMICS FOR PREDICTION OF DISEASE PROGRESSION IN PATIENTS WITH IGA NEPHROPATHY Open
Background and Aims IgA nephropathy (IgAN) may lead to kidney failure. The urinary proteomics biomarker-based classifier (IgAN237) may predict progression at the time of kidney biopsy [1]. We now studied whether IgAN237 predicts disease pr…