Raluca Ecaterina Haliga
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View article: Iron Deficiency in Heart Failure: From ESC Guidelines to Clinical Practice at a Romanian Hospital
Iron Deficiency in Heart Failure: From ESC Guidelines to Clinical Practice at a Romanian Hospital Open
Background: Iron deficiency (ID) is a frequent comorbidity in heart failure (HF), associated with reduced functional capacity and poor prognosis. Although the European Society of Cardiology (ESC) guidelines recommend systematic screening a…
View article: Immunomodulatory Effects of RAAS Inhibitors: Beyond Hypertension and Heart Failure
Immunomodulatory Effects of RAAS Inhibitors: Beyond Hypertension and Heart Failure Open
The renin–angiotensin–aldosterone system (RAAS) plays a central role in cardiovascular and renal homeostasis and is increasingly recognized for its broad immunomodulatory effects. Pharmacological RAAS inhibition, primarily via angiotensin-…
View article: Severe carbamazepine-induced cardiotoxicity with multisystem involvement: early recognition and advanced therapeutic approach
Severe carbamazepine-induced cardiotoxicity with multisystem involvement: early recognition and advanced therapeutic approach Open
Carbamazepine (CBZ) toxicity is a medical emergency due to severe neurological and cardiovascular risks. Management is challenging due to CBZ’s prolonged elimination, enterohepatic recirculation, and active metabolites. We report a severe …
View article: Mortality Predictors in Patients with Severe COPD Exacerbation
Mortality Predictors in Patients with Severe COPD Exacerbation Open
Background: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of intensive care unit (ICU) admissions and in-hospital mortality. Several hematological inflammatory biomarkers, including neutro…
View article: Resumption versus discontinuation of direct oral anticoagulation after an episode of gastrointestinal bleeding: a systematic review and meta-analysis of rebleeding episodes
Resumption versus discontinuation of direct oral anticoagulation after an episode of gastrointestinal bleeding: a systematic review and meta-analysis of rebleeding episodes Open
Introduction Background. Direct oral anticoagulants (DOACs) have become standard of care in long term anticoagulation. Extensive research has focused on this new class of drugs that despite their benefits, have an associated risk of bleedi…
View article: Electrocardiogram Features in Non-Cardiac Diseases: From Mechanisms to Practical Aspects
Electrocardiogram Features in Non-Cardiac Diseases: From Mechanisms to Practical Aspects Open
Despite the noteworthy advancements and the introduction of new technologies in diagnostic tools for cardiovascular disorders, the electrocardiogram (ECG) remains a reliable, easily accessible, and affordable tool to use. In addition to it…
View article: The use of intravenous immunoglobulin in the treatment of Hashimoto’s encephalopathy: case based review
The use of intravenous immunoglobulin in the treatment of Hashimoto’s encephalopathy: case based review Open
Background Hashimoto’s encephalopathy (HE) is a controversial immunological neuropsychiatric disease, with a poorly understood pathogenesis. It is characterized by symptoms of acute or subacute encephalopathy which usually occur in the pre…
View article: Distinct Features of Vascular Diseases in COVID-19
Distinct Features of Vascular Diseases in COVID-19 Open
The Coronavirus Disease 2019 (COVID-19) pandemic was declared in early 2020 after several unexplained pneumonia cases were first reported in Wuhan, China, and subsequently in other parts of the world. Commonly, the disease comprises severa…
View article: Age, blood tests and comorbidities and AIMS65 risk scores outperform Glasgow-Blatchford and pre-endoscopic Rockall score in patients with upper gastrointestinal bleeding
Age, blood tests and comorbidities and AIMS65 risk scores outperform Glasgow-Blatchford and pre-endoscopic Rockall score in patients with upper gastrointestinal bleeding Open
ABC score is the most accurate in predicting in-hospital mortality in both mixed and non-variceal bleeding population. PERS and GBS should be used to determine need for endoscopic and surgical intervention, respectively. Lactate can be use…
View article: Severe Intentional Corrosive (Nitric Acid) Acute Poisoning: A Case Report and Literature Review
Severe Intentional Corrosive (Nitric Acid) Acute Poisoning: A Case Report and Literature Review Open
Despite being one of the most debilitating conditions encountered in the field of toxicology, there is a lack of neutralization measures for the toxins involved in acute corrosive poisoning, and this promotes progressive contact injury of …
View article: Severe iron-deficiency anaemia in a patient with heart failure: A case report and review of the literature
Severe iron-deficiency anaemia in a patient with heart failure: A case report and review of the literature Open
Background: Anaemia of different etiologies, but also iron deficiency without anaemia, worse symptoms and prognosis of patients with heart failure or coronary artery disease. Development of anemia in patients with chronic heart failure is …
View article: Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review
Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review Open
Infective endocarditis is a severe infective heart disease, commonly involving native or prosthetic valves. It frequently presents with univalvular involvement and simultaneous double valve or multivalvular involvement is rarely described.…
View article: The Significance of Low Magnesium Levels in COVID-19 Patients
The Significance of Low Magnesium Levels in COVID-19 Patients Open
Magnesium is the fourth most common mineral in the human body and the second richest intracellular cation. This element is necessary for many physiological reactions, especially in the cardiovascular and respiratory systems. COVID-19 is an…
View article: Nontrombotic Pulmonary Embolism: Different Etiology, Same Significant Consequences
Nontrombotic Pulmonary Embolism: Different Etiology, Same Significant Consequences Open
Nontrombotic pulmonary embolism represents the embolization of different types of materials (cells, organisms, gas, foreign material) into pulmonary circulation. The disease is uncommon, and clinical presentation together with laboratory f…
View article: Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus
Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus Open
In recent years, direct oral anticoagulants (DOAC) have accumulated evidence of efficacy and safety in various clinical scenarios and are approved for a wide spectrum of indications. Still, they are currently used off-label for left ventri…
View article: Management of Hyponatremia in Heart Failure: Practical Considerations
Management of Hyponatremia in Heart Failure: Practical Considerations Open
Hyponatremia is commonly encountered in the setting of heart failure, especially in decompensated, fluid-overloaded patients. The pathophysiology of hyponatremia in patients with heart failure is complex, including numerous mechanisms: inc…
View article: Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review
Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review Open
Serotonin syndrome (SS) is a clinical toxidrome with high variability in clinical practice. It develops due to increased serotonin levels in the central nervous system. With an underestimated frequency, SS can develop following an overdose…
View article: The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients
The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients Open
Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematolog…
View article: Cardiac Biomarkers and Risk Scores in Relation with History of Atherosclerotic Cardiovascular Disease in Patients Admitted with COVID-19: The Experience of an Eastern European Center
Cardiac Biomarkers and Risk Scores in Relation with History of Atherosclerotic Cardiovascular Disease in Patients Admitted with COVID-19: The Experience of an Eastern European Center Open
Background: Data regarding the combined prognostic role of biomarkers and risk scores in relation with the history of atherosclerotic cardiovascular disease (ASCVD) in COVID-19 patients are lacking. Methods: The aim of this observational c…
View article: The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity Open
In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, o…
View article: Rare Causes of Acute Coronary Syndrome: Carbon Monoxide Poisoning
Rare Causes of Acute Coronary Syndrome: Carbon Monoxide Poisoning Open
Acute coronary syndrome (ACS) is a spectrum of clinical and paraclinical disorders arising from an imbalance of oxygen demand and supply to the myocardium. The most common cause is atherosclerosis; however, other rare causes such as carbon…
View article: Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves
Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves Open
Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac …
View article: From chronic pruritus to neuroendocrine tumor: A case report
From chronic pruritus to neuroendocrine tumor: A case report Open
Chronic pruritus is a major and distressing symptom of many diseases of dermatological, neurological, psychogenic or systemic origin. This chronic itch could be a presenting sign of malignancy; therefore, paraneoplastic pruritus has also b…
View article: Acute Clinical Syndromes and Suspicion of SARS-CoV-2 Infection: The Experience of a Single Romanian Center in the Early Pandemic Period
Acute Clinical Syndromes and Suspicion of SARS-CoV-2 Infection: The Experience of a Single Romanian Center in the Early Pandemic Period Open
Background and Objectives: During the coronavirus disease 2019 (COVID-19) pandemic, patients with chronic diseases suffering exacerbations have required acute medical care. The purpose of our study was to determine useful criteria for the …
View article: Macrophage Accumulation and Angiogenesis in Epicardial Adipose Tissue in Cardiac Patients with or without Chronic Heart Failure
Macrophage Accumulation and Angiogenesis in Epicardial Adipose Tissue in Cardiac Patients with or without Chronic Heart Failure Open
Routinely measuring epicardial fat had become a novel tool for cardiovascular risk stratification. Structural changes in epicardial adipose tissue (EAT), including fat thickness, inflammation, and angiogenesis, have been described in coron…
View article: Rib Exostoses Presenting as Mediastinal Masses: A Rare Presentation and Minireview of the Literature
Rib Exostoses Presenting as Mediastinal Masses: A Rare Presentation and Minireview of the Literature Open
Costal osteocartilaginous exostoses, also known as osteochondromas, are the most common neoplasms of the long bones but are rare tumors of the ribs. Osteochondroma is often asymptomatic and incidentally observed. Tumors typically begin to …
View article: Sub‑classification of non‑inflammatory and inflammatory surgical aortic aneurysms and the association of histological characteristics with potential risk factors
Sub‑classification of non‑inflammatory and inflammatory surgical aortic aneurysms and the association of histological characteristics with potential risk factors Open
The present study aimed to analyze the histological characteristics of surgical thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) specimens on the basis of the most recent consensus documents on non-inflammatory and inflam…
View article: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AND GROWTH HORMONE SEGRETAGOGUE RECEPTOR-1A MRNA EXPRESSION IN ADIPOSE TISSUE OBTAINED FROM SEVERELY OBESE PATIENTS
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AND GROWTH HORMONE SEGRETAGOGUE RECEPTOR-1A MRNA EXPRESSION IN ADIPOSE TISSUE OBTAINED FROM SEVERELY OBESE PATIENTS Open
The presence of the micro-defects in the vicinity of a macro-crack tip can either amplify or suppress the SIF (stress intensity factor) of the macro-crack, thus influence the macro-crack propagating path and rate. In the present work, we n…