Phool Chandra
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View article: MOLECULAR DOCKING INSIGHTS AND ANTIOXIDANT ACTIVITY OF ISOLATED BIOACTIVE COMPOUND FROM STEVIA REBAUDIANA LEAVES
MOLECULAR DOCKING INSIGHTS AND ANTIOXIDANT ACTIVITY OF ISOLATED BIOACTIVE COMPOUND FROM STEVIA REBAUDIANA LEAVES Open
This study investigates the molecular docking interactions and antioxidant activity of an isolated bioactive compound from Stevia rebaudiana leaves, highlighting its potential as an antioxidant and anti-inflammatory agent. Stevia rebaudian…
View article: QbD-Driven Development and Validation of a Novel RP-HPLC Method for Quantitative Determination of Coenzyme Q10 in Single and Combined Dosage Forms
QbD-Driven Development and Validation of a Novel RP-HPLC Method for Quantitative Determination of Coenzyme Q10 in Single and Combined Dosage Forms Open
The objective of the study was to develop and validate an authentic RP-HPLC methods based on Quality by Design (QbD) for the quantitative analysis of Coenzyme Q10 (CoQ10) in both single and combined dosage forms with clomiphene citrate (CC…
View article: Implications of Endothelin-1 Antagonist, ACE Inhibitor and Statin on Experimentally Induced Hyperlipidemic Nephropathy in Rats
Implications of Endothelin-1 Antagonist, ACE Inhibitor and Statin on Experimentally Induced Hyperlipidemic Nephropathy in Rats Open
Chronic kidney disease (CKD) is a growing global health challenge, with prevalence steadily increasing worldwide. Current pharmacological interventions are often insufficient to completely prevent or slow the progression of nephropathy. To…
View article: Chemical Characterization and Docking Insights into Rhein Isolated from Cassia fistula Seeds as a Natural Antioxidant Candidate
Chemical Characterization and Docking Insights into Rhein Isolated from Cassia fistula Seeds as a Natural Antioxidant Candidate Open
This study explores the phytochemical profiling, isolation, and antioxidant evaluation of bioactive constituents from Cassia fistula seed extracts. Seeds were extracted using ethanol through Soxhlet extraction. The ethanolic extract yielde…
View article: ELUCIDATING THE PHYTOCHEMICAL PROFILE AND THERAPEUTIC POTENTIALS OF MORINGA OLEIFERA: AN INTEGRATIVE APPROACH
ELUCIDATING THE PHYTOCHEMICAL PROFILE AND THERAPEUTIC POTENTIALS OF MORINGA OLEIFERA: AN INTEGRATIVE APPROACH Open
Medicines are a substance that serves nutritional, therapeutics, or preventative purposes while the term "herbal medicine" is used to describe plant-based products with therapeutics, preventative, or dietary benefits. This review intends t…
View article: Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats
Experimental investigation of Cynodon dactylon ethanolic extract against allergic conjunctivitis in rats Open
Allergic conjunctivitis refers to inflammation of the conjunctiva, often treated with allopathic drugs that may cause side effects. Plant-based preparations are considered safer alternatives; therefore, this study aims to evaluate the anti…
View article: An Overview and Review of Growth Factors inWound Healing: Emerging Trends and Innovations
An Overview and Review of Growth Factors inWound Healing: Emerging Trends and Innovations Open
Wound healing is a complex process involving various cellular and molecular events aimed at restoring tissue integrity. Growth factors play a pivotal role in orchestrating these events by regulating cell migration, proliferation, different…
View article: Explainable and Responsible AI in Neuroscience
Explainable and Responsible AI in Neuroscience Open
View article: Assessment of Risk Factors and Drug Usage Pattern in Coronary Artery Disease among COVID-19 Patients in a Tertiary Care Hospital
Assessment of Risk Factors and Drug Usage Pattern in Coronary Artery Disease among COVID-19 Patients in a Tertiary Care Hospital Open
Coronary artery disease (CAD) continues to be one of the leading causes of morbidity and mortality. Previous studies have shown a high incidence of CAD in patients with risk factors such as diabetes mellitus, hypertension, dyslipidemia, sm…
View article: A review on pathophysiology and managements of allergic conjunctivitis
A review on pathophysiology and managements of allergic conjunctivitis Open
Allergic disorder is a serious issue affecting 40% of the population. The most well-known visual illness in clinical practise is undoubtedly visual sensitivity. The impact of numerous variables, including genetics and pollution, is taken i…
View article: Evaluation of the Oral Toxicity of Litchi chinensis Pericarp Extract in Experimental Rats
Evaluation of the Oral Toxicity of Litchi chinensis Pericarp Extract in Experimental Rats Open
A wide range of experiments have yielded empirical evidence pertaining to the efficacy of medicinal plants in the therapeutic treatment of several disorders. However, the use of herbs without conducting a thorough assessment of their effec…
View article: Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer’s Disease
Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer’s Disease Open
Himanshu Sharma and Phool Chandra Author informationPDFCitations Corresponding author. Correspondence: Mr. Himanshu Sharma Reseach Scholar, Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer Universi…
View article: Oral toxicity study of Nelumbo nucifera Gaertn. rhizome extract in rats
Oral toxicity study of Nelumbo nucifera Gaertn. rhizome extract in rats Open
Following OECD guidelines, the acute oral toxicity study of hydroalcoholic extract of Nelumbo nucifera Gaertn.(HNN) was conducted at 2000 mg/kg.Three rats received a single dose of the HNN at 48 h of interval, weighing 2000 mg/kg.After car…
View article: Neuropathy; its profile and experimental nerve injury neuropathic pain models: A Review
Neuropathy; its profile and experimental nerve injury neuropathic pain models: A Review Open
Neuropathy is a terrible disorder that has a wide range of aetiologies. Drug-Induced Neuropathy, which happens whenever a chemical agent damages the peripheral nerve system, has been linked here to iatrogenic creation of some drugs. It is …
View article: Harnessing the potential of probiotics in the treatment of alcoholic liver disorders
Harnessing the potential of probiotics in the treatment of alcoholic liver disorders Open
In the current scenario, prolonged consumption of alcohol across the globe is upsurging an appreciable number of patients with the risk of alcohol-associated liver diseases. According to the recent report, the gut-liver axis is crucial in …
View article: A Detailed Review of Molecular Pathways and Mechanisms Responsible for theDevelopment and Aggravation of Neuropathy and Nephropathy in Diabetes
A Detailed Review of Molecular Pathways and Mechanisms Responsible for theDevelopment and Aggravation of Neuropathy and Nephropathy in Diabetes Open
Background: Diabetic mellitus is responsible for triggering many conditions, such as neuropathy, nephropathy, and retinopathy. Hyperglycemia leads to the development of oxidative stress conditions, activation of pathways, and generation of…
View article: Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats
Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats Open
OBJECTIVE: The current study aimed to estimate phytochemical screening, in vitro antioxidant activity, and gastroprotective activity of Sesamum indicum Linn ethanolic extract. MATERIALS AND METHODS: The current study was held out by ulcera…
View article: Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review
Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review Open
Diabetic neuropathy, also called peripheral diabetic neuropathy (PDN), is among the most significant diabetes health consequences, alongside diabetic nephropathy, diabetic cardiomyopathy and diabetic retinopathy. Diabetic neuropathy is the…
View article: In vivo Wound Healing Potential of Raloxifene Nanoemulsion Gel for the Management of Postmenopausal Cutaneous Wounds
In vivo Wound Healing Potential of Raloxifene Nanoemulsion Gel for the Management of Postmenopausal Cutaneous Wounds Open
Background: Depletion in estrogen level(s) especially in postmenopausal women is reported to have delayed wound healing effects; hence we have evaluated the wound healing potential of raloxifene in rat model. Objectives: Investigating the …
View article: Electrocatalytic Assisted One Pot Three Component Reaction for Construction of Highly Substituted Pyridine
Electrocatalytic Assisted One Pot Three Component Reaction for Construction of Highly Substituted Pyridine Open
View article: Isolation of Thymol from <i>Trachyspermum ammi</i> Fruits for Treatment of Diabetes and Diabetic Neuropathy in STZ‐Induced Rats
Isolation of Thymol from <i>Trachyspermum ammi</i> Fruits for Treatment of Diabetes and Diabetic Neuropathy in STZ‐Induced Rats Open
Terpenoids and phenols from Trachyspermum ammi ( T. ammi ) have reported some pharmacological actions. The objective of the work was to isolate the active constituent, its identification by spectroscopic techniques, and evaluation of the a…
View article: Microwave Assisted Synthesis, Characterization and Evaluation for Antimicrobial Activity of Novel 1, 5-Benzothiazepines
Microwave Assisted Synthesis, Characterization and Evaluation for Antimicrobial Activity of Novel 1, 5-Benzothiazepines Open
Aims: 1,5-benzothiazepine ring is privileged aromatic heterocycles of interest to organic and medicinal chemists because of its ease of synthesis and biological activities. This study aims to synthesize new series of 1, 5-benzothiazepine b…
View article: Evaluation of Acute, Sub-Chronic Oral Toxicity Studies and Anti-Inflammatory Activity of Blumea mollis in Experimental Animals
Evaluation of Acute, Sub-Chronic Oral Toxicity Studies and Anti-Inflammatory Activity of Blumea mollis in Experimental Animals Open
Objective: The goal of this study was to test the ethanol extract of the aerial part of the Blumea mollis (Asteraceae) for acute and sub-chronic toxicity as well as anti-inflammatory efficacy.
Methods: The shade dried aerial part of Blume…
View article: Design and in-vitro Evaluation of Float-adhesive Famotidine Microspheres by using Natural Polymers for Gastroretentive Properties
Design and in-vitro Evaluation of Float-adhesive Famotidine Microspheres by using Natural Polymers for Gastroretentive Properties Open
Objectives: In the present investigation a novel oral drug delivery system was developed by combining two different techniques floating and mucoadhesive system so called floatadhesive, in order to obtain a controlled system that could rema…
View article: Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system
Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system Open
View article: Hepatoprotective Activity and Lipid Peroxidation of Boerhavia repens L. against Carbon TetrachlorideInduced Toxicity
Hepatoprotective Activity and Lipid Peroxidation of Boerhavia repens L. against Carbon TetrachlorideInduced Toxicity Open
Introduction: Hepatic disease stand as one of the foremost health troubles worldwide with liver cirrhosis and drug-induced liver injury accounting 9th leading cause of death in western and developing countries.Objective: Hepatoprotective a…
View article: Lipid Peroxidation and Hepatoprotective Activity of Bauhinia Vahli Against Carbon Tetra Chloride Induced Toxicity
Lipid Peroxidation and Hepatoprotective Activity of Bauhinia Vahli Against Carbon Tetra Chloride Induced Toxicity Open
Introduction:Liver cirrhosis has become a serious health problem because of the wider use of prescribed medications with adverse reactions in the modern life of today or drug misuse.Objective: In the present study, the hepatoprotective act…
View article: A Comprehensive Review: Medicago sativa
A Comprehensive Review: Medicago sativa Open
India has a great wealth of different plant drugs that occur naturally and have great pharmacological activities.Medicago sativa L. (M.sativa) is one of the widely well-known folklore medicinal herbs.The M. Sativa is a medicinal plant and …
View article: Pharmacological Screening Techniques for Evaluation of Gastric Ulcers: Principles, Mechanism and Procedures
Pharmacological Screening Techniques for Evaluation of Gastric Ulcers: Principles, Mechanism and Procedures Open
A gastric ulcer is the most common disease in the world.Different allopathic medicine or drugs are used for the treatment of gastric ulcers.These are effective in the treatment of ulcers but produce various side effects.These days use alte…
View article: A Review on Morphology, Traditional Uses and Pharmacological Activities and Phytochemicals of Cucumis trigonus
A Review on Morphology, Traditional Uses and Pharmacological Activities and Phytochemicals of Cucumis trigonus Open
The Cucumis trigonus (Family: Cucurbitaceae) is commonly known as "Thummittikai" in Tamil, "Bitter gourd" in English, and "Vishala" in Sanskrit.The fruit pulp of Cucumis trigonus is bitter, acrid, thermogenic, anthelmintic, liver tonic, ca…