Radhe Mohan
YOU?
Author Swipe
View article: PREDICTING SUSPECTED RADIATION NECROSIS IN BRAIN CANCER PATIENTS WITH A MACHINE LEARNING MODEL BASED ON THE PROTON LINEAL ENERGY SPECTRUM
PREDICTING SUSPECTED RADIATION NECROSIS IN BRAIN CANCER PATIENTS WITH A MACHINE LEARNING MODEL BASED ON THE PROTON LINEAL ENERGY SPECTRUM Open
View article: BIOLOGICAL EFFECT INCORPORATED BEAM ANGLE OPTIMIZATION OF IMPT FOR BRAIN CANCER PATIENTS
BIOLOGICAL EFFECT INCORPORATED BEAM ANGLE OPTIMIZATION OF IMPT FOR BRAIN CANCER PATIENTS Open
View article: Bayesian Learning to Reduce Cardiac Risk for Locally Advanced NSCLC Patients Based on Personalized Radiotherapy Prescription
Bayesian Learning to Reduce Cardiac Risk for Locally Advanced NSCLC Patients Based on Personalized Radiotherapy Prescription Open
Purpose Radiation-induced heart damage is a significant concern in the treatment of non-small cell lung cancer (NSCLC) that can have debilitating or life-threatening consequences. Current strategies focus on minimizing heart exposure, but …
View article: Radiation doses to cardiac substructures predict elevation in high-sensitivity cardiac troponin T (hs-cTnT) levels in radiotherapy for lung cancer
Radiation doses to cardiac substructures predict elevation in high-sensitivity cardiac troponin T (hs-cTnT) levels in radiotherapy for lung cancer Open
Purpose Cardiotoxicity is a major concern for patients undergoing thoracic radiotherapy. This study compared the predictive power of radiation dose-volume histogram (DVH) parameters and radiomic/dosiomic features of the whole heart (WH) an…
View article: Weekly changes in ventilation response for photon and proton lung cancer patients during radiotherapy
Weekly changes in ventilation response for photon and proton lung cancer patients during radiotherapy Open
Purpose Conformal dose distributions in proton radiotherapy promise to reduce normal tissue toxicity such as radiation-induced pneumonitis, but this has not been fully realized in clinical trials. To further investigate dose and toxicity, …
View article: Bayesian Counterfactual Machine Learning Individualizes Radiation Modality Selection to Mitigate Immunosuppression
Bayesian Counterfactual Machine Learning Individualizes Radiation Modality Selection to Mitigate Immunosuppression Open
PURPOSE Lymphocytes play critical roles in cancer immunity and tumor surveillance. Radiation-induced lymphopenia (RIL) is a common side effect observed in patients with cancer undergoing chemoradiation therapy (CRT), leading to impaired im…
View article: A novel microdosimetry-based formalism for cell survival modelling applicable to hypofractionated radiotherapy
A novel microdosimetry-based formalism for cell survival modelling applicable to hypofractionated radiotherapy Open
Objectives. Hypofractionated radiotherapy requires reliable cell survival models for doses much higher than the standard 2 Gy, for which the linear-quadratic (LQ) model is not applicable. We developed an alternative approach applicable to …
View article: Prediction of Grade 4 radiation-induced lymphopenia during chemoradiation therapy for lung cancer patients: Insights from two past trials
Prediction of Grade 4 radiation-induced lymphopenia during chemoradiation therapy for lung cancer patients: Insights from two past trials Open
Baseline ALC and lung V5Gy were identified as predictors for G4-RIL, consistent with findings from previous studies. Treatment plan optimization aiming at reducing low-dose bath in the lungs could be an effective strategy for se…
View article: Quantifying changes in ventilation for photon- and proton-treated patients according to dose and pneumonitis development
Quantifying changes in ventilation for photon- and proton-treated patients according to dose and pneumonitis development Open
Treatment of non-small cell lung cancer with proton therapy allows for delivery of high radiation dose while sparing critical normal tissue structures compared to conventional photon therapy. However, there are currently no established cli…
View article: Human-induced pluripotent stem cell derived cerebral organoids as a model of normal brain tissue response to proton radiation
Human-induced pluripotent stem cell derived cerebral organoids as a model of normal brain tissue response to proton radiation Open
View article: Development of machine learning models utilizing proton energy spectrum and dose to for post-treatment T2 hyperintensity prediction
Development of machine learning models utilizing proton energy spectrum and dose to for post-treatment T2 hyperintensity prediction Open
View article: A library of proton lineal energy spectra spanning the full range of clinically relevant energies
A library of proton lineal energy spectra spanning the full range of clinically relevant energies Open
Purpose In locations where the proton energy spectrum is broad, lineal energy spectrum‐based proton biological effects models may be more accurate than dose‐averaged linear energy transfer (LET d ) based models. However, the development of…
View article: Defining the Optimal Radiation-induced Lymphopenia Metric to Discern Its Survival Impact in Esophageal Cancer
Defining the Optimal Radiation-induced Lymphopenia Metric to Discern Its Survival Impact in Esophageal Cancer Open
Reaching grade ≥3 RIL in week 3 of CRT for esophageal cancer is the strongest RIL metric to distinguish survival outcomes. We suggest that this metric should be the target for lymphopenia-mitigating strategies and propose this metric to be…
View article: Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum?
Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum? Open
View article: Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform
Mimicking large spot‐scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform Open
Previously, a synchrotron‐based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to…
View article: Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation
Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation Open
Purpose Proton FLASH has been investigated using cyclotron and synchrocyclotron beamlines but not synchrotron beamlines. We evaluated the impact of dose rate (ultra-high [UHDR] vs. conventional [CONV]) and beam configuration (shoot-through…
View article: Clinical Translation of a Deep Learning Model of Radiation-Induced Lymphopenia for Esophageal Cancer
Clinical Translation of a Deep Learning Model of Radiation-Induced Lymphopenia for Esophageal Cancer Open
The proposed DL model-guided strategy to incorporate the immune system as iOAR in IMRT and IMPT optimization has the potential for radiation-induced lymphopenia mitigation. A prospective clinical trial is planned.
View article: Radiation-Induced Lymphopenia is a Causal Mediator of Survival After Chemoradiation Therapy for Esophagus Cancer
Radiation-Induced Lymphopenia is a Causal Mediator of Survival After Chemoradiation Therapy for Esophagus Cancer Open
G4RIL was found to mediate survival; however, a statistically significant direct effect of PBT on survival was not observed. In other words, the statistical significance of survival benefit from protons over photons in this EC cohort was l…
View article: REDUCTION OF RADIATION INDUCED LYMPHOPENIA RISK BY REDUCING SPOT SIZE IN INTENSITY MODULATED PROTON THERAPY FOR ESOPHAGEAL CANCER
REDUCTION OF RADIATION INDUCED LYMPHOPENIA RISK BY REDUCING SPOT SIZE IN INTENSITY MODULATED PROTON THERAPY FOR ESOPHAGEAL CANCER Open
View article: A PLATFORM TO FACILITATE MULTI-INSTITUTIONAL STUDIES TO BOOST PARTICLE THERAPY
A PLATFORM TO FACILITATE MULTI-INSTITUTIONAL STUDIES TO BOOST PARTICLE THERAPY Open
View article: Personalized Composite Dosimetric Score–Based Machine Learning Model of Severe Radiation-Induced Lymphopenia Among Patients With Esophageal Cancer
Personalized Composite Dosimetric Score–Based Machine Learning Model of Severe Radiation-Induced Lymphopenia Among Patients With Esophageal Cancer Open
View article: A molecular dynamics simulation of the abrupt changes in the thermodynamic properties of water after formation of nano-bubbles / nano-cavities induced by passage of charged particles
A molecular dynamics simulation of the abrupt changes in the thermodynamic properties of water after formation of nano-bubbles / nano-cavities induced by passage of charged particles Open
We present a multi-scale formalism that accounts for the formation of nano-scale bubbles/cavities owing to a burst of water molecules after the passage of high energy charged particles that leads to the formation of hot non-ionizing excita…
View article: Development and comparison of lineal energy spectrum-based and LETd-based proton-RBE models
Development and comparison of lineal energy spectrum-based and LETd-based proton-RBE models Open
View article: Comparing 90-Day Postoperative Mortality After Neoadjuvant Proton-Based Versus Photon-Based Chemoradiotherapy for Esophageal Cancer
Comparing 90-Day Postoperative Mortality After Neoadjuvant Proton-Based Versus Photon-Based Chemoradiotherapy for Esophageal Cancer Open
No statistically significant difference was observed in postoperative 90DM after esophagectomy for cancer between PBT and photon-based neoadjuvant chemoradiotherapy. However, among older patients a signal was observed that PBT may reduce 9…
View article: Some Quality Concerns in the Big Data and Machine Learning Software Industry
Some Quality Concerns in the Big Data and Machine Learning Software Industry Open
View article: Editorial: Innovations, advances, and challenges in precision radiation oncology physics
Editorial: Innovations, advances, and challenges in precision radiation oncology physics Open
With the continuous advancement of all components contributing to the therapeutic delivery of radiation within the oncology clinic, modern radiotherapy is becoming more precise than ever due to technological innovations and their widesprea…
View article: Incorporating variable RBE in IMPT optimization for ependymoma
Incorporating variable RBE in IMPT optimization for ependymoma Open
Purpose To study the dosimetric impact of incorporating variable relative biological effectiveness (RBE) of protons in optimizing intensity‐modulated proton therapy (IMPT) treatment plans and to compare it with conventional constant RBE op…
View article: Outcomes and complications of Titanium elastic nailing for forearm bones fracture in children: our experience in a district general hospital in the United Kingdom
Outcomes and complications of Titanium elastic nailing for forearm bones fracture in children: our experience in a district general hospital in the United Kingdom Open
Intramedullary Titanium elastic nailing (TENS) is successfully used for irreducible and displaced forearm bone fractures in children. The purpose of this study was to report the potential complications and functional outcomes associated wi…
View article: Intertrack interaction at ultra-high dose rates and its role in the FLASH effect
Intertrack interaction at ultra-high dose rates and its role in the FLASH effect Open
Background: The mechanism responsible for the FLASH effect remains undetermined yet critical to the clinical translation of FLASH radiotherapy. The potential role of intertrack interactions in the FLASH effect, arising from the high spatio…
View article: Quantifying the Effect of 4-Dimensional Computed Tomography–Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy
Quantifying the Effect of 4-Dimensional Computed Tomography–Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy Open