Ram Raj Singh
YOU?
Author Swipe
View article: National Mortality Databases to Assess Disease Burden in Systemic Autoimmune Diseases: A Valuable Resource, But with Limitations
National Mortality Databases to Assess Disease Burden in Systemic Autoimmune Diseases: A Valuable Resource, But with Limitations Open
Disease‐specific mortality statistics are useful measures of disease burden. Population‐based studies from a few United States counties have reported mortality in systemic autoimmune diseases (SAID). However, due to substantial differences…
View article: OP0197 PREMATURE MORTALITY IN RHEUMATOID ARTHRITIS: A NATIONWIDE ANALYSIS OF YPLL, ASMR, MEDIAN AGE OF DEATH, AND ODDS OF EARLY DEATH
OP0197 PREMATURE MORTALITY IN RHEUMATOID ARTHRITIS: A NATIONWIDE ANALYSIS OF YPLL, ASMR, MEDIAN AGE OF DEATH, AND ODDS OF EARLY DEATH Open
View article: 101 Lupus nephritis mortality by sex, age, geographic region, urbanization, and race/ethnicity: a nationwide population-based study
101 Lupus nephritis mortality by sex, age, geographic region, urbanization, and race/ethnicity: a nationwide population-based study Open
Background Kidney involvement is common in lupus. Lupus and kidney diseases incur poor outcomes in people from racial/ethnic minority groups. Previous studies have utilized the national registry of patients with end-stage renal disease (ES…
View article: 601 Racial/Ethnic and regional differences by place of death in lupus nephritis
601 Racial/Ethnic and regional differences by place of death in lupus nephritis Open
Background Mortality rates for lupus and lupus nephritis significantly vary by race/ethnicity and geographic region. Here, we examine place of death as an indirect indicator of disease outcome and accessibility to healthcare on a national …
View article: Secular Trends in Dermato-Polymyositis Mortality, 1999-2022: No Disproportionate Increase During the COVID-19 Pandemic in the United States Except in the Northeast States of New York and Pennsylvania
Secular Trends in Dermato-Polymyositis Mortality, 1999-2022: No Disproportionate Increase During the COVID-19 Pandemic in the United States Except in the Northeast States of New York and Pennsylvania Open
View article: Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis
Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis Open
In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs. Such immune cell clusters are called tertiary l…
View article: OP0266 HIGHER RISK OF LUPUS MORTALITY IN URBANIZED THAN IN LESS-URBANIZED NEIGHBORHOODS
OP0266 HIGHER RISK OF LUPUS MORTALITY IN URBANIZED THAN IN LESS-URBANIZED NEIGHBORHOODS Open
Background Lupus mortality differs by sex, race/ethnicity, and geographical region in the United States, with females, blacks, and residents of the South census region experiencing higher age-standardized mortality rates relative to their …
View article: Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades
Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades Open
Objective We aimed to assess SSc mortality by age in the general population over the past five decades. Methods This is a population-based study using a national mortality database and the census data for all US residents. We calculated th…
View article: Worsening premature death burden gap from systemic sclerosis in men and black persons: A US nationwide population-based study
Worsening premature death burden gap from systemic sclerosis in men and black persons: A US nationwide population-based study Open
Objective: Male sex and black race incur poor prognosis in systemic sclerosis (SSc). There is no nationwide population-based assessment of premature SSc death burden by sex and race. Methods: This is a population-based study comprising all…
View article: Diverse Roles of NETosis in the Pathogenesis of Lupus
Diverse Roles of NETosis in the Pathogenesis of Lupus Open
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are relea…
View article: Vascular Thrombosis in COVID-19: A Potential Association with Antiphospholipid Antibodies
Vascular Thrombosis in COVID-19: A Potential Association with Antiphospholipid Antibodies Open
Background Vascular thrombosis is common in patients with coronavirus disease 2019 (COVID-19). Etiologies underlying this complication are unclear. Purpose To determine the prevalence of antiphospholipid (aPL), including lupus anticoagulan…
View article: Trends in Systemic Sclerosis Mortality Over Forty‐Eight Years, 1968–2015: A US Population–Based Study
Trends in Systemic Sclerosis Mortality Over Forty‐Eight Years, 1968–2015: A US Population–Based Study Open
Objective To identify secular trends associated with systemic sclerosis (SSc) mortality over a 48‐year period. Methods Using national mortality data compiled by the Centers for Disease Control and Prevention’s Wide‐Ranging Online Data for …
View article: 166 The increasing prevalence of SLE, 2001–2011: united states nationwide population-based estimates
166 The increasing prevalence of SLE, 2001–2011: united states nationwide population-based estimates Open
Background The prevalence rate of SLE in previous reports has widely varied by as much as 12-fold over the years, which is likely due to variabilities in study populations, case definitions, and case ascertainment sources. Previous studies…
View article: 168 Relative burden of premature mortality in lupus
168 Relative burden of premature mortality in lupus Open
Background Disease burden is the impact of a health problem on a given area, which can be used to set healthcare and research priorities and identify high-risk populations. Disease burden can be measured using a variety of indicators such …
View article: 167 Roles of skin-resident dendritic cells and T cells in the pathogenesis of cutaneous lupus
167 Roles of skin-resident dendritic cells and T cells in the pathogenesis of cutaneous lupus Open
Background Pathogenesis of cutaneous lupus is unclear. Skin harbors at least three subsets of dendritic cells (DC): Langerhans cells (LC) that reside in the epidermis, langerin-expressing dermal DC that reside in the dermis (LangdDC), and …
View article: 11 Induction of vasculitic lesions in lupus-prone mice: A model for lupus-associated peripheral vascular disease
11 Induction of vasculitic lesions in lupus-prone mice: A model for lupus-associated peripheral vascular disease Open
Background Systemic lupus erythematosus is an autoimmune disorder that affects many organs. Many patients develop vasculitis in skin and internal organs. There is no effective treatment for lupus-associated vasculitis. Research on the path…
View article: Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant
Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant Open
View article: Quantitative Proteomics Using Formalin-fixed, Paraffin-embedded Biopsy Tissues in Inflammatory Disease
Quantitative Proteomics Using Formalin-fixed, Paraffin-embedded Biopsy Tissues in Inflammatory Disease Open
This is the first report of lupus nephritis kidney proteomics using FFPE tissue. We concluded that archived FFPE tissues can be reliably used for proteomic analyses in inflammatory diseases, with a caveat that certain proteins related to i…
View article: Self‐glycerophospholipids activate murine phospholipid‐reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading
Self‐glycerophospholipids activate murine phospholipid‐reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading Open
Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid‐reactive invariant NKT‐cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid‐reactive T cells (PLT). We report that…
View article: AI-15 Pathogenesis of lupus dermatitis: different skin-resident dendritic cell subsets exhibit different migration patterns, utilize different mechanisms of migration, and play different roles
AI-15 Pathogenesis of lupus dermatitis: different skin-resident dendritic cell subsets exhibit different migration patterns, utilize different mechanisms of migration, and play different roles Open
Background Pathogenesis of lupus dermatitis is not clear. Skin contains two subsets of dendritic cells (DC) that express langerin: Langerhans cells (LC) reside in the epidermis; they induce tolerance to skin autoantigens in lupus-prone MRL…
View article: CS-32 SLE-YPLL (years of potential life lost) as a measure of relative burden of premature mortality
CS-32 SLE-YPLL (years of potential life lost) as a measure of relative burden of premature mortality Open
Background Disease burden is the impact of a health problem on a given area, which can be used to prioritize actions in health, assess performance of healthcare and disease management, identify high-risk populations, and set research prior…
View article: II-07 Pathogenesis of pulmonary lupus and vasculitis: trafficking of innate B1 B cells to the lungs as a novel mechanism
II-07 Pathogenesis of pulmonary lupus and vasculitis: trafficking of innate B1 B cells to the lungs as a novel mechanism Open
Background Up to 50% patients with SLE may develop pneumonitis, vasculitis and diffuse pulmonary hemorrhage (DPH). Advances in the pathogenesis of pulmonary lupus have been hampered because of the heterogeneity of clinical findings and pau…
View article: SLE mortality remains disproportionately high, despite improvements over the last decade
SLE mortality remains disproportionately high, despite improvements over the last decade Open
Despite a marked improvement in 10-year survival for systemic lupus erythematosus (SLE) patients over the past five decades, mortality rates from SLE remain high compared to those in the general population. SLE was also among the leading c…
View article: pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis
pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis Open
Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear. We demonstrate that, in animals and humans with systemic fibrosis, plasmacytoid DCs (pDCs) are unaffected or are reduced systemically (spleen…
View article: 46-Year Trends in Systemic Lupus Erythematosus Mortality in the United States, 1968 to 2013
46-Year Trends in Systemic Lupus Erythematosus Mortality in the United States, 1968 to 2013 Open
None.
View article: Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis
Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis Open
Invariant natural killer T (iNKT) cells are unique subset of innate-like T cells recognizing glycolipids. iNKT cells can rapidly produce copious amounts of cytokines upon antigen stimulation and exert potent immunomodulatory activities for…
View article: Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways.
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways. Open
Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = …